|
1
|
Hooper JE and Scott MP: Communicating with
Hedgehogs. Nat Rev Mol Cell Biol. 6:306–317. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Ingham PW and McMahon AP: Hedgehog
signaling in animal development: paradigms and principles. Genes
Dev. 15:3059–3087. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
McMahon AP, Ingham PW and Tabin CJ:
Developmental roles and clinical significance of hedgehog
signaling. Curr Top Dev Biol. 53:1–114. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Pasca di Magliano M and Hebrok M: Hedgehog
signalling in cancerformation and maintenance. Nat Rev Cancer.
3:903–911. 2003. View
Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ruiz i Altaba A, Mas C and Stecca B: The
Gli code: an information nexus regulating cellfate, stemness and
cancer. Trends Cell Biol. 17:438–447. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Bale AE and Yu KP: The hedgehogpathway and
basal cell carcinomas. Hum Mol Genet. 10:757–762. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Daya-Grosjean L and Couvé-Privat S: Sonic
hedgehog signaling in basal cell carcinomas. Cancer Lett.
225:181–192. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Berman DM, Karhadkar SS, Hallahan AR, et
al: Medulloblastoma growth inhibition by hedgehog pathway blockade.
Science. 297:1559–1561. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Watkins DN, Berman DM, Burkholder SG, Wang
B, Beachy PA and Baylin SB: Hedgehog signalling within airway
epithelialprogenitors and in small-cell lung cancer. Nature.
422:313–317. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Gialmanidis IP, Bravou V, Amanetopoulou
SG, Varakis J, Kourea H and Papadaki H: Overexpression of hedgehog
pathwaymolecules and FOXM1 in non-small cell lung carcinomas. Lung
Cancer. 66:64–74. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Berman DM, Karhadkar SS, Maitra A, et al:
Widespread requirement for Hedgehog ligand stimulation in growth of
digestive tract tumours. Nature. 425:846–851. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Mori Y, Okumura T, Tsunoda S, Sakai Y and
Shimada Y: Gli-1 expression is associated with lymph nodemetastasis
and tumor progression in esophageal squamous cell carcinoma.
Oncology. 70:378–389. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Qualtrough D, Buda A, Gaffield W, Williams
AC and Paraskeva C: Hedgehog signalling in colorectal tumour cells:
induction of apoptosis with cyclopamine treatment. Int J Cancer.
110:831–837. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
ten Haaf A, Bektas N, von Serenyi S, et
al: Expression of the glioma-associated oncogene homolog (GLI) 1 in
human breast cancer is associated with unfavourable overall
survival. BMC Cancer. 9:2982009. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Karhadkar SS, Bova GS, Abdallah N, et al:
Hedgehog signalling in prostateregeneration, neoplasia and
metastasis. Nature. 431:707–712. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Liao X, Siu MK, Au CW, et al: Aberrant
activation of hedgehog signaling pathway in ovarian cancers: effect
onprognosis, cellinvasion and differentiation. Carcinogenesis.
30:131–140. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Feng YZ, Shiozawa T, Miyamoto T, et al:
Overexpression of hedgehog signalingmolecules and its involvement
in the proliferation of endometrial carcinoma cells. Clin Cancer
Res. 13:1389–1398. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Chen JK, Taipale J, Cooper MK and Beachy
PA: Inhibition of Hedgehog signaling by direct binding of
cyclopamine to Smoothened. Genes Dev. 16:2743–2748. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Chen JK, Taipale J, Young KE, Maiti T and
Beachy PA: Small molecule modulation of Smoothened activity. In:
Proc Natl Acad Sci USA. 99. pp. 14071–14076. 2002; View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Ma X, Chen K, Huang S, et al: Frequent
activation of the hedgehog pathway in advanced gastric
adenocarcinomas. Carcinogenesis. 26:1698–1705. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Lee SY, Han HS, Lee KY, et al: Sonic
hedgehog expression in gastriccancer and gastric adenoma. Oncol
Rep. 17:1051–1055. 2007.PubMed/NCBI
|
|
22
|
Ohta M, Tateishi K, Kanai F, et al:
p53-Independent negative regulation of p21/cyclin-dependent
kinase-interacting protein 1 by the sonic
hedgehog-glioma-associated oncogene 1 pathway in gastric carcinoma
cells. Cancer Res. 65:10822–10829. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Fukaya M, Isohata N, Ohta H, et al:
Hedgehog signal activation in gastric pitcell and in diffuse-type
gastric cancer. Gastroenterology. 131:14–29. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Yoo YA, Kang MH, Kim JS and Oh SC: Sonic
hedgehog signaling promotesmotility and invasiveness of gastric
cancer cells through TGF-beta-mediated activation of the ALK5-Smad
3 pathway. Carcinogenesis. 29:480–490. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Nagai S, Nakamura M, Yanai K, et al: Gli1
contributes to the invasiveness of pancreatic cancer through matrix
metalloproteinase-9 activation. Cancer Sci. 99:1377–1384. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Feldmann G, Dhara S, Fendrich V, et al:
Blockade of hedgehog signaling inhibits pancreatic cancerinvasion
and metastases: a new paradigm for combination therapy in solid
cancers. Cancer Res. 67:2187–2196. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Naef M, Ishiwata T, Friess H, Büchler MW,
Gold LI and Korc M: Differential localization of transforming
growth factor-beta isoforms in human gastricmucosa and
overexpression in gastric carcinoma. Int J Cancer. 71:131–137.
1997. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Ebert MP, Yu J, Miehlke S, et al:
Expression of transforming growth factor beta-1 in gastriccancer
and in the gastric mucosa of first-degree relatives of patients
with gastric cancer. Br J Cancer. 82:1795–1800. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Nag S, Qin J, Srivenugopal KS, et al: The
MDM2-p53 pathway revisited. J Biomed Res. 27:254–271. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Fu H, Hu Z, Wen J, Wang K and Liu Y:
TGF-beta promotesinvasion and metastasis of gastric cancer cells by
increasing fascin1 expression viaERK and JNK signal pathways. Acta
Biochim Biophys Sin (Shanghai). 41:648–656. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Raman D, Baugher PJ, Thu YM and Richmond
A: Role of chemokines in tumor growth. Cancer Lett. 256:137–165.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Salvucci O, Bouchard A, Baccarelli A, et
al: The role of CXCR4 receptor expression in breast cancer: a large
tissue microarray study. Breast Cancer Res Treat. 97:275–283. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Kodama J, Hasengaowa, Seki N, Kusumoto T
and Hiramatsu Y: Expression of the CXCR4 and CCR7 chemokine
receptors in human endometrial cancer. Eur J Gynaecol Oncol.
28:370–375. 2007.PubMed/NCBI
|
|
34
|
Engl T, Relja B, Marian D, et al: CXCR4
chemokine receptor mediates prostate tumor cell adhesion through
alpha5 and beta3 integrins. Neoplasia. 8:290–301. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Lee HJ, Kim SW, Kim HY, et al: Chemokine
receptor CXCR4 expression, function, and clinical implications in
gastric cancer. Int J Oncol. 34:473–480. 2009.PubMed/NCBI
|
|
36
|
Yoon JW, Gilbertson R, Iannaccone S,
Iannaccone P and Walterhouse D: Defining a role for Sonic hedgehog
pathway activation in desmoplastic medulloblastoma by identifying
GLI1 target genes. Int J Cancer. 124:109–119. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Katoh M: Integrative genomic analyses of
CXCR4: transcriptional regulation of CXCR4 based onTGFbeta, Nodal,
Activinsignaling and POU5F1, FOXA2, FOXC2, FOXH1, SOX17, and GFI1
transcription factors. Int J Oncol. 36:415–420. 2010.PubMed/NCBI
|
