Bilateral mammary duct ectasia induced by sulpiride-associated hyperprolactinemia: A case report

Cong,Yizi; Zou,Haidong; Qiao,Guangdong; Lin,Jun; Wang,Xingmiao; Li,Xiaohui; Li,Yalun; Zhu,Shiguang

doi:10.3892/ol.2015.3034

May-2015 Volume 9 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2015 Volume 9 Issue 5

Full Size Image

Case Report

Bilateral mammary duct ectasia induced by sulpiride-associated hyperprolactinemia: A case report

Authors:
- Yizi Cong
- Haidong Zou
- Guangdong Qiao
- Jun Lin
- Xingmiao Wang
- Xiaohui Li
- Yalun Li
- Shiguang Zhu
View Affiliations / Copyright

Affiliations: Department of Breast Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong 264400, P.R. China
Pages: 2181-2184
|
Published online on: March 12, 2015

https://doi.org/10.3892/ol.2015.3034
Expand metrics +

Abstract

A 32 year old female diagnosed with schizophrenia was treated with sulpiride, trihexyphenidyl and alprazolam for 6 years. A physical examination revealed bilateral nipple retraction and a non-tender mass in the left breast, with little nipple discharge. Tests revealed high levels of carbohydrate antigen 125, serum prolactin and testosterone levels, and ultrasound revealed a number of masses in the bilateral breasts; the largest mass (2.2x1.3 cm) was located in the left breast. A rich blood flow signal was identified around the nodule. The ducts in the bilateral breasts exhibited cystic ectasia. Multiple enlarged lymph nodes were found in the bilateral axillae. Mammography revealed thickened breast tissue without an evident mass, and calcification. A segmental mastectomy was performed and subsequent histological examination revealed multiple dilated ducts, the largest of which contained eosinophilic material. The pathological diagnosis was of breast duct dilatation. Bacterial culture and drug sensitivity analysis of the secretions from the cystic cavity revealed no bacterial growth, and an acid fast bacillus stain was negative. Extravasation of the surgical wound occurred 1 month later, and Staphylococcus epidermidis was observed using a bacterial culture. This was treated with moxifloxacin for 1 week. It was suggested that the patient should switch to a prolactin sparing antipsychotic in view of the hyperprolactinemia, however, the patient refused. After a clinical follow-up of 16 months, the wound had healed well and no palpable mass was found in the breast.

View Figures

View References

1	McHoney M, Munro F and Mackinlay G: Mammary duct ectasia in children: report of a shortseries and review of the literature. Early Hum Dev. 87:527–530. 2011. View Article : Google Scholar : PubMed/NCBI
2	Haagensen CD: Mammary-duct ectasia; a disease that may simulate carcinoma. Cancer. 4:749–761. 1951. View Article : Google Scholar : PubMed/NCBI
3	Thomas WG, Williamson RC, Davies JD and Webb AJ: The clinical syndrome of mammary duct ectasia. Br J Surg. 69:423–425. 1982. View Article : Google Scholar : PubMed/NCBI
4	Dogan BE, Ceyhan K, Tukel S, Saylisoy S and Whitman GJ: Ductal dilatation as the manifesting sign of invasive ductal carcinoma. J Ultrasound Med. 24:1413–1417. 2005.PubMed/NCBI
5	Duchesne N, Skolnik S and Bilmer S: Ultrasound appearance of chronic mammary duct ectasia. Can Assoc Radiol J. 56:297–300. 2005.PubMed/NCBI
6	Peters F and Schuth W: Hyperprolactinemia and nonpuerperal mastitis (duct ectasia). JAMA. 261:1618–1620. 1989. View Article : Google Scholar : PubMed/NCBI
7	D'Orsi C, Mendelson EB, Ikeda D, et al: Breast Imaging Reporting Data SystemACR BI-RADS - breast imaging atlas. American College of Radiology; Reston, VA: 2003
8	Leung AK and Kao CP: Mammary duct ectasia: a cause of bloody nipple discharge. J Natl Med Assoc. 96:543–545. 2004.PubMed/NCBI
9	Browning J, Bigrigg A and Taylor I: Symptomatic and incidental mammary duct ectasia. J R Soc Med. 79:715–716. 1986.PubMed/NCBI
10	Rahal RM, Junior RF, Reis C, Pimenta FC, Netto JC and Paulinelli RR: Prevalence of bacteria in the nipple discharge of patients with duct ectasia. Int J Clin Pract. 59:1045–1050. 2005. View Article : Google Scholar : PubMed/NCBI
11	Sweeney DJ and Wylie EJ: Mammographic appearances of mammary duct ectasia that mimic carcinoma in a screening programme. Australas Radiol. 39:18–23. 1995. View Article : Google Scholar : PubMed/NCBI
12	Rizzatto G and Chersevani R: Breastultrasound and new technologies. Eur J Radiol. 27(Suppl 2): S242–249. 1998. View Article : Google Scholar : PubMed/NCBI
13	Sakorafas GH: Nipple discharge: currentdiagnostic and therapeutic approaches. Cancer Treat Rev. 27:275–282. 2001. View Article : Google Scholar : PubMed/NCBI
14	Ying T, Li Q, Xu L, Liu F and Hu B: Three-dimensional ultrasound appearance of pelvic floor in nulliparouswomen and pelvic organ prolapse women. Int J Med Sci. 9:894–900. 2012. View Article : Google Scholar : PubMed/NCBI
15	Wang Z, Leonard MH Jr..Khamapirad T and Castro CY: Bilateral extensive ductitis obliterans manifested by bloody nipple discharge in a patient with long-term diabetes mellitus. Breast J. 13:599–602. 2007. View Article : Google Scholar : PubMed/NCBI
16	Rahal RM, de Freitas-Júnior R and Paulinelli RR: Risk factors for duct ectasia. Breast J. 11:262–265. 2005. View Article : Google Scholar : PubMed/NCBI
17	Dixon JM, Ravisekar O, Chetty U and Anderson TJ: Periductal mastitis and duct ectasia: different conditions with different aetiologies. Br J Surg. 83:820–822. 1996. View Article : Google Scholar : PubMed/NCBI
18	Kitahara S, Wakabayashi M, Shiba T, Nonaka K, Nonaka H and Kobayashi I: Mammary duct ectasia in children presenting bloody nipple discharge: a case in a pubertal girl. J Pediatr Surg. 36:E22001. View Article : Google Scholar : PubMed/NCBI
19	Shousha S, Backhouse CM, Dawson PM, Alaghband-Zadeh J and Burn I: Mammary ductectasia and pituitary adenomas. Am J Surg Pathol. 12:130–133. 1988. View Article : Google Scholar : PubMed/NCBI
20	Paparrigopoulos T, Liappas J, Tzavellas E, Mourikis I and Soldatos C: Amisulpride-induced hyperprolactinemia is reversible following discontinuation. Prog Neuropsychopharmacol Biol Psychiatry. 31:92–96. 2007. View Article : Google Scholar : PubMed/NCBI
21	Kovács L and Kovács G: Endocrine side effects among psychiatric patients treated with antipsychotics. Neuropsychopharmacol Hung. 8:61–66. 2006.[In Hungarian]. PubMed/NCBI
22	Mir A, Shivakumar K, Williamson RJ, McAllister V, O'Keane V and Aitchison KJ: Change in sexual dysfunction with aripiprazole: a switching or add-on study. J Psychopharmacol. 22:244–253. 2008. View Article : Google Scholar : PubMed/NCBI
23	Marchese G, Ruiu S, Casti P, et al: Carmoxirole is able to reduce amisulpride-induced hyperprolactinemia without affecting its central effect. Eur J Pharmacol. 447:109–114. 2002. View Article : Google Scholar : PubMed/NCBI
24	Bliesener N, Yokusoglu H, Quednow BB, Klingmüller D and Kühn KU: Usefulness of bromocriptine in the treatment of amisulpride-induced hyperprolactinemia: a case report. Pharmacopsychiatry. 37:189–191. 2004. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Bilateral mammary duct ectasia induced by sulpiride-associated hyperprolactinemia: A case report

This article is mentioned in:

Abstract

Figure 1

Related Articles