Concurrent chronic neutrophilic leukemia blast crisis and multiple myeloma: A case report and literature review

Shi,Jinning; Ni,Ying; Li,Jianyong; Qiu,Hairong; Miao,Kourong

doi:10.3892/ol.2015.3043

May-2015 Volume 9 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

May-2015 Volume 9 Issue 5

Full Size Image

Case Report

Concurrent chronic neutrophilic leukemia blast crisis and multiple myeloma: A case report and literature review

Authors:
- Jinning Shi
- Ying Ni
- Jianyong Li
- Hairong Qiu
- Kourong Miao
View Affiliations / Copyright

Affiliations: Department of Hematology, The Affiliated Jiangning Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China , Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Hospital, Nanjing, Jiangsu 210029, P.R. China
Pages: 2208-2210
|
Published online on: March 16, 2015

https://doi.org/10.3892/ol.2015.3043
Expand metrics +

Abstract

The current study presents the case of a 78‑year‑old male with concurrent chronic neutrophilic leukemia (CNL) and multiple myeloma (MM) who developed acute myeloid leukemia after two years of treatment with hydroxyurea, cyclophosphamide, prednisone and thalidomide. The patient presented with mature neutrophilic leukocytosis, hepatosplenomegaly, a high neutrophil alkaline phosphatase score and an absence of the Philadelphia chromosome or the BCR‑ABL fusion gene. A bone marrow aspirate smear and biopsy indicated that the CNL coexisted with a plasma cell neoplasm. In addition, monoclonal λ‑paraproteinemia was detected by serum protein immunofixation electrophoresis, and bone lesions were identified in multiple vertebrae. The patient achieved complete remission following one cycle of induction chemotherapy with the decitabine regimen in combination with the low‑dose cytarabine, aclarubicin and granulocyte-colony stimulating factor (CAG) priming regimen. The occurrence of CNL and MM concurrently is extremely rare and thus, it has only been reported in a small number of cases. The occurrence of CNL and MM in the same patient as two distinct hematological malignancies indicates the neoplastic transformation of a pluripotent stem cell. Decitabine combined with the CAG priming regimen may present a good therapeutic strategy for elderly patients with secondary acute myeloid leukemia.

View Figures

View References

1	Elliott MA: Chronic neutrophilic leukemia: a contemporary review. Curr Hematol Rep. 3:210–217. 2004.PubMed/NCBI
2	Bird JM, Owen RG, D'Sa S, et al: Haemato-oncology Task Force of British Committee for Standards in Haematology (BCSH) and UK Myeloma Forum: Guidelines for the diagnosis and management of multiple myeloma 2011. Br J Haematol. 154:32–75. 2011. View Article : Google Scholar : PubMed/NCBI
3	Standen GR, Jasani B, Wagstaff M and Wardrop CA: Chronic neutrophilic leukemia and multiple myeloma. An association with lambda light chain expression. Cancer. 66:162–166. 1990. View Article : Google Scholar : PubMed/NCBI
4	Dinçol G, Nalçaci M, Doğan O, Aktan M, Küçükkaya R, Ağan M and Dinçol K: Coexistence of chronic neutrophilic leukemia with multiple myeloma. Leuk Lymphoma. 43:649–651. 2002. View Article : Google Scholar : PubMed/NCBI
5	Shen Y, Xue Y, Li J, Pan J and Wu Y: Clinical, cytogenetic and dual-color FISH studies on five cases of myelodysplastic syndrome or acute myeloid leukemia patients with 1;7 translocation. Chin Med J (Engl). 116:231–234. 2003.PubMed/NCBI
6	Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, et al: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues4th. IARC Press; Lyon, France: 2008
7	Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR and Sultan C: Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 33:451–458. 1976. View Article : Google Scholar : PubMed/NCBI
8	Tanaka M, Kimura R, Matsutani A, Zaitsu K, Oka Y and Oizumi K: Coexistence of chronic myelogenous leukemia and multiple myeloma. Case report and review of the literature. Acta Haematol. 99:221–223. 1998. View Article : Google Scholar : PubMed/NCBI
9	Chang H and Shih LY: Concurrence of multiple myeloma and idiopathic erythrocytosis. Acta Clin Belg. 64:434–435. 2009. View Article : Google Scholar : PubMed/NCBI
10	Eskazan AE, Ongoren S, Ar MC, Soysal T, Ferhanoglu B, Aki H and Aydin Y: Essential thrombocythemia and multiple myeloma: two rare diseases in one patient. Clin Lymphoma Myeloma Leuk. 11:442–445. 2011. View Article : Google Scholar : PubMed/NCBI
11	Kawauchi K, Mori H, Sugiyama H, Oshimi K and Hirayama A: Multiple myeloma with coexistent myelofibrosis: improvement of myelofibrosis following recovery from multiple myeloma after treatment with melphalan and prednisolone. Jpn J Med. 30:483–486. 1991. View Article : Google Scholar : PubMed/NCBI
12	Ganetsky A: The role of decitabine for the treatment of acute myeloid leukemia. Ann Pharmacother. 46:1511–1517. 2012. View Article : Google Scholar : PubMed/NCBI
13	Wei G, Ni W, Chiao JW, Cai Z, Huang H and Liu D: A meta-analysis of CAG (cytarabine, aclarubicin, G-CSF) regimen for the treatment of 1029 patients with acute myeloid leukemia and myelodysplastic syndrome. J Hematol Oncol. 4:462011. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Concurrent chronic neutrophilic leukemia blast crisis and multiple myeloma: A case report and literature review

This article is mentioned in:

Abstract

Figure 1

Related Articles