Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors

Lee,Jun‑Hsiung; Huang,Hsuan‑Ying; Lan,Jui; Hwang,Cheng‑Cheng; Liu,Chih‑Yi

doi:10.3892/ol.2015.3055

May-2015 Volume 9 Issue 5

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May-2015 Volume 9 Issue 5

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Case Report

Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors

Authors:
- Jun‑Hsiung Lee
- Hsuan‑Ying Huang
- Jui Lan
- Cheng‑Cheng Hwang
- Chih‑Yi Liu
View Affiliations / Copyright

Affiliations: Department of Pathology, Sijhih Cathay General Hospital, Sijhih, New Taipei City, Taiwan, R.O.C., Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, R.O.C., Department of Pathology, Chang Gung Memorial Hospital, Keelung, Taiwan, R.O.C.
Pages: 2275-2277
|
Published online on: March 18, 2015

https://doi.org/10.3892/ol.2015.3055
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Abstract

Cutaneous myoepithelioma is a peculiar and recently recognized neoplasm exhibiting purely myoepithelial differentiation. These lesions affect different areas of the body, and are characterized by heterogenous morphological and immunophenotypical features. The majority of cutaneous myoepitheliomas behave in a benign fashion, however, the risk for local recurrence is higher with incomplete resection. A relatively newly described variant of myoepithelioma exhibits syncytial cytological features. The current study reports a case of cutaneous syncytial myoepithelioma presenting as a painless and papular skin lesion. The presence of the Ewing sarcoma RNA-binding protein 1 gene rearrangement in the present case supported the diagnosis of a myoepithelial tumor. The patient subsequently underwent local excision of the tumor and was followed up twice in the year after surgery. At the time of writing, the patient was alive and no recurrences had been identified. Furthermore, the current study discusses how this myoepithelial neoplasm may be distinguished from other problematic spindle or epithelioid cell tumors, particularly superficial dermal lesions.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors

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