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Article

Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay

  • Authors:
    • Jin Zhang
    • Hongxia Li
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Beijing Shijitan Hospital, Capital Medical University, Haidian, Beijing 100038, P.R. China
  • Pages: 2374-2380
    |
    Published online on: March 18, 2015
       https://doi.org/10.3892/ol.2015.3056
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Abstract

Ovarian cancer has a poor prognosis, primarily due to the heterogeneity in chemosensitivity among patients. In the present study, this heterogeneity was evaluated in ovarian epithelial cancer (OEC) using an in vitro adenosine triphosphate tumor chemosensitivity assay (ATP‑TCA). Specimens were collected from 80 patients who underwent cytoreductive surgery. Viable ovarian cancer cells obtained from malignant tissues were tested for sensitivity to paclitaxel (PTX), carboplatin (CBP), topotecan (TPT), gemcitabine (GEM), docetaxel (TXT), etoposide, bleomycin and 4‑hydroperoxycyclophosphamide using ATP‑TCA. The sensitivity, specificity, positive predictive value and negative predictive value for the clinical chemotherapy sensitivity of OEC were 88.6, 77.8, 83 and 84.8%, respectively. PTX demonstrated the highest sensitivity of all agents tested (82.5% in all specimens, 85.7% in recurrent specimens), followed by CBP (58.8 and 60.7%, respectively). The sensitivities to PTX and docetaxel (P<0.001) were correlated, in addition to those of CBP, TPT and GEM (P<0.001). Early‑stage (I/II) and high‑ to mildly‑differentiated OEC specimens revealed a lower chemosensitivity than advanced‑stage (III) or low‑differentiated specimens, respectively. The present study indicated that ATP‑TCA is an effective method for guiding the choice of chemotherapy drugs. Notable heterogeneity of chemosensitivity was observed in the OEC specimens.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang J and Li H: Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay . Oncol Lett 9: 2374-2380, 2015.
APA
Zhang, J., & Li, H. (2015). Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay . Oncology Letters, 9, 2374-2380. https://doi.org/10.3892/ol.2015.3056
MLA
Zhang, J., Li, H."Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay ". Oncology Letters 9.5 (2015): 2374-2380.
Chicago
Zhang, J., Li, H."Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay ". Oncology Letters 9, no. 5 (2015): 2374-2380. https://doi.org/10.3892/ol.2015.3056
Copy and paste a formatted citation
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Spandidos Publications style
Zhang J and Li H: Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay . Oncol Lett 9: 2374-2380, 2015.
APA
Zhang, J., & Li, H. (2015). Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay . Oncology Letters, 9, 2374-2380. https://doi.org/10.3892/ol.2015.3056
MLA
Zhang, J., Li, H."Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay ". Oncology Letters 9.5 (2015): 2374-2380.
Chicago
Zhang, J., Li, H."Heterogeneity of tumor chemosensitivity in ovarian epithelial cancer revealed using the adenosine triphosphate-tumor chemosensitivity assay ". Oncology Letters 9, no. 5 (2015): 2374-2380. https://doi.org/10.3892/ol.2015.3056
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