Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report

Feng,Gang; Wang,Dong; Chen,Li; Xie,Gang; Zhang,Yu; Wang,Jing; Du,Xiao-Bo

doi:10.3892/ol.2015.3061

May-2015 Volume 9 Issue 5

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May-2015 Volume 9 Issue 5

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Case Report Open Access

Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report

Authors:
- Gang Feng
- Dong Wang
- Li Chen
- Gang Xie
- Yu Zhang
- Jing Wang
- Xiao-Bo Du
View Affiliations / Copyright

Affiliations: Department of Oncology, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China, Department of Surgery, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China, Department of General Practice, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China, Department of Pathology, Mianyang Central Hospital, Mianyang, Sichuan 621000, P.R. China

Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2013-2016
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Published online on: March 20, 2015

https://doi.org/10.3892/ol.2015.3061
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Abstract

The present study described a rare case of malignant conversion of a solitary papilloma in the trachea, in addition to reviewing the current literature. A 54‑year‑old male presented with a cough, sputum and dyspnea. Chest computed tomography revealed a mediastinal soft‑tissue mass in the trachea. A tumor biopsy, performed using a flexible bronchofiberscope, identified a squamous cell papilloma with moderate to severe atypical hyperplasia, as well as the formation of squamous cell carcinoma. Polymerase chain reaction analysis did not detect presence of human papilloma virus in the tumor. The patient was subsequently treated with radiotherapy and no evidence of recurrence was observed during a two‑year follow‑up period. To the best of our knowledge, this is the first study to describe the malignant conversion of a solitary papilloma in the trachea, which was subsequently treated with radiotherapy.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Malignant conversion of a solitary squamous cell papilloma in the trachea treated by radiotherapy: A case report

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