Securin promotes migration and invasion via matrix metalloproteinases in glioma cells

  • Authors:
    • Haicheng Yan
    • Wei Wang
    • Changwu Dou
    • Fuming Tian
    • Songtao Qi
  • View Affiliations

  • Published online on: March 26, 2015     https://doi.org/10.3892/ol.2015.3074
  • Pages: 2895-2901
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Abstract

Human securin, encoded by pituitary tumor transforming gene 1, is implicated in several oncogenic processes in the pathogenesis of brain tumors, including glioma. The aim of the present study was to examine the effect of securin on the migration and invasion of glioma cells. The results revealed that the overexpression of securin in glioma LN‑229 cells significantly increased the invasion and transmigration abilities. By contrast, these abilities were significantly reduced by the downregulation of securin in glioma U373 cells. Furthermore, the results demonstrated that securin overexpression and downregulation significantly increased and decreased the levels of matrix metalloproteinase 2 and 9, respectively. These findings indicate a promotive role for securin in glioma migration and invasion, which may involve the action of matrix metalloproteinases.
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June-2015
Volume 9 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yan H, Wang W, Dou C, Tian F and Qi S: Securin promotes migration and invasion via matrix metalloproteinases in glioma cells. Oncol Lett 9: 2895-2901, 2015
APA
Yan, H., Wang, W., Dou, C., Tian, F., & Qi, S. (2015). Securin promotes migration and invasion via matrix metalloproteinases in glioma cells. Oncology Letters, 9, 2895-2901. https://doi.org/10.3892/ol.2015.3074
MLA
Yan, H., Wang, W., Dou, C., Tian, F., Qi, S."Securin promotes migration and invasion via matrix metalloproteinases in glioma cells". Oncology Letters 9.6 (2015): 2895-2901.
Chicago
Yan, H., Wang, W., Dou, C., Tian, F., Qi, S."Securin promotes migration and invasion via matrix metalloproteinases in glioma cells". Oncology Letters 9, no. 6 (2015): 2895-2901. https://doi.org/10.3892/ol.2015.3074