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Article

Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer

  • Authors:
    • Cemil Bilir
    • Huseyin Engin
    • Murat Can
    • Sevili Likhan
    • Derya Demirtas
    • Fatih Kuzu
    • Taner Bayraktaroglu
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, Division of Medical Oncology, Recep Tayyip Erdoğan University School of Medicine, Rize 53020, Turkey, Department of Internal Medicine, Bülent Ecevit University School of Medicine, Kozlu, Zonguldak 67000, Turkey, Department of Biochemistry, Bülent Ecevit University School of Medicine, Kozlu, Zonguldak 67000, Turkey
  • Pages: 2819-2824
    |
    Published online on: April 1, 2015
       https://doi.org/10.3892/ol.2015.3094
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Abstract

Obesity appears to be associated with an increased risk of breast cancer (BC) and an inferior oncological outcome at the time of diagnosis, with poor outcomes most prominent in cases of triple‑negative BC (TNBC). The present study analyzed serum tumor necrosis factor (TNF)‑like weak inducer of apoptosis (TWEAK) and TNF receptor associated factor‑6 (TRAF) protein expression levels in 48 patients with non‑metastatic BC and 26 obese control patients (without BC). The mean age of the cohort was 52.5 years (range, 35‑78 years) and the patients had a median body mass index of 33.5 kg/m2 (range, 30‑47 kg/m2). In the study population, 27.1% of BC patients were triple negative and 70.8% were hormone receptor (HR)‑positive. Median serum TRAF6 expression was 0.90 ng/ml (range, 0.55‑1.53 ng/ml) in the 13 TNBC patients and 0.63 ng/ml (range, 0.49‑1.22 ng/ml) in the 35 HR‑positive BC patients; thus, TRAF6 expression was significantly higher in the TNBC patients compared with the obese control group (0.90 vs. 0.73 ng/ml; P=0.033). Furthermore, median serum TRAF6 expression levels were significantly higher in HR‑negative patients compared with HR‑positive patients (0.83 vs. 0.62 ng/ml; P=0.002). The present study demonstrated that serum TRAF6 expression levels were increased in TNBC and HR‑negative patients with non‑metastatic BC compared with HR‑ and human epidermal growth factor receptor 2‑positive cases or the obese healthy control group. Therefore, elevated TRAF6 expression may be a poor prognostic factor in non‑metastatic BC. In addition, we propose that progesterone (PR) negativity may be a more useful poor prognosis factor than estrogen receptor (ER) negativity, as TRAF6 expression levels were higher in the PR‑negative patients compared with the ER-negative patients.
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1 

Rose DP, Gilhooly EM and Nixon DW: Adverse effects of obesity on breast cancer prognosis and the biological actions of leptin (Review). Int J Oncol. 21:1285–1292. 2002.PubMed/NCBI

2 

Majed B, Moreau T, Senouci K, et al: Is obesity an independent prognosis factor in woman breast cancer? Breast Cancer Res Treat. 111:329–342. 2008. View Article : Google Scholar : PubMed/NCBI

3 

de Azambuja E, McCaskill-Stevens W, Francis P, et al: The effect of body mass index on overall and disease-free survival in node-positive breast cancer patients treated with docetaxel and doxorubicincontaining adjuvant chemotherapy: The experience of the BIG 02–98 trial. Breast Cancer Res Treat. 119:145–53. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Sestak I, Distler W, Forbes JF, et al: Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial. J Clin Oncol. 28:3411–3415. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Sparano JA, Wang M, Zhao F, et al: Obesity at diagnosis is associated with inferior outcomes in hormone receptor-positive operable breast cancer. Cancer. 118:5937–5946. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Pierobon M and Frankenfeld CL: Obesity as a risk factor for triple-negative breast cancers: a systematic review and meta-analysis. Breast Cancer Res Treat. 137:307–314. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Vona-Davis L and Rose DP: Adipokines as endocrine, paracrine and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer. 14:189–206. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Schäffler A, Schölmerich J and Buechler C: Mechanisms of disease: adipokines and breast cancer - endocrine and paracrine mechanisms that connect adiposity and breast cancer. Nat Clin Pract Endocrinol Metab. 3:345–354. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Stephenson GD and Rose DP: Breast cancer and obesity: an update. Nutr Cancer. 45:1–16. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Weichhaus M, Broom I and Bermano G: The molecular contribution of TNF-α in the link between obesity and breast cancer. Oncol Rep. 25:477–483. 2011.PubMed/NCBI

11 

Chicheportiche Y, Bourdon PR, Xu H, et al: TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem. 272:32401–32410. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Winkles JA: The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting. Nat Rev Drug Discov. 7:411–425. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Kawakita T, Shiraki K, Yamanaka Y, et al: Functional expression of TWEAK in human colonic adenocarcinoma cells. Int J Oncol. 26:87–93. 2005.PubMed/NCBI

14 

Kawakita T, Shiraki K, Yamanaka Y, et al: Functional expression of TWEAK in human hepatocellular carcinoma: possible implication in cell proliferation and tumor angiogenesis. Biochem Biophys Res Commun. 318:726–733. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Pickart CM: Mechanisms underlying ubiquitination. Annu Rev Biochem. 70:503–533. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Mukhopadhyay D and Riezman H: Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science. 315:201–205. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Paul PK, Gupta SK, Bhatnagar S, et al: Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice. J Cell Biol. 191:1395–1411. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Tavassoli FA and Devilee P: Tumours of the breastWorld Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. IARC Press; Lyon: pp. 13–59. 2003

19 

Oken MM, Creech RH, Tormey DC, et al: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

20 

Johns N, Stephens NA and Preston T: Muscle protein kinetics in cancer cachexia. Curr Opin Support Palliat Care. 6:417–423. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Cohen S, Brault JJ, Gygi SP, et al: During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol. 185:1083–1095. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Acharyya S and Guttridge DC: Cancer cachexia signaling pathways continue to emerge yet much still points to the proteasome. Clin Cancer Res. 13:1356–1361. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Lee SJ and Glass DJ: Treating cancer cachexia to treat cancer. Skelet Muscle. 1:22011. View Article : Google Scholar : PubMed/NCBI

24 

Fischer P and Hilfiker-Kleiner D: Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis. Basic Res Cardiol. 102:279–297. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Jones SA, Scheller J and Rose-John S: Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J Clin Invest. 121:3375–3383. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Penna F, Costamagna D, Fanzani A, Bonelli G, Baccino FM and Costelli P: Muscle wasting and impaired myogenesis in tumor bearing mice are prevented by ERK inhibition. PLoS One. 5:136042010. View Article : Google Scholar

27 

Jagoe RT and Goldberg AL: What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? Curr Opin Clin Nutr Metab Care. 4:183–190. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Lecker SH, Solomon V, Mitch WE and Goldberg AL: Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J Nutr. (Suppl):129:227S–237S. 1999.PubMed/NCBI

29 

Bodine SC, Latres E, Baumhueter S, et al: Identification of ubiquitin ligases required for skeletal muscle atrophy. Science. 294:1704–1708. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Pickart CM: Mechanisms underlying ubiquitination. Annu Rev Biochem. 70:503–533. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Yang WL, Wang J, Chan CH, et al: The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. 325:1134–1138. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Yamashita M, Fatyol K, Jin C, Wang X, Liu Z and Zhang YE: TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell. 31:918–924. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Yamamoto M, Ito T, Shimizu T, et al: Epigenetic alteration of the NF-κB-inducing kinase (NIK) gene is involved in enhanced NIK expression in basal-like breast cancer. Cancer Sci. 101:2391–2397. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Arsenic R, Lehmann A, Budczies J, et al: Analysis of PIK3CA mutations in breast cancer subtypes. Appl Immunohistochem Mol Morphol. 22:50–56. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Polek TC, Talpaz M, Darnay BG and Spivak-Kroizman T: TWEAK mediates signal transduction and differentiation of RAW264.7 cells in the absence of Fn14/TweakR. Evidence for a second TWEAK receptor. J Biol Chem. 278:32317–32323. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Yoriki R, Akashi S, Sho M, et al: Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer. Exp Ther Med. 2:103–108. 2011.PubMed/NCBI

37 

Chao DT, Su M, Tanlimco S, et al: Expression of TweakR in breast cancer and preclinical activity of enavatuzumab, a humanized anti-TweakR mAb. J Cancer Res Clin Oncol. 139:315–325. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Chacón MR, Richart C, Gómez JM, et al: Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity. Cytokine. 33:129–137. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Liu H, Tamashiro S, Baritaki S, et al: TRAF6 activation in multiple myeloma: a potential therapeutic target. Clin Lymphoma Myeloma Leuk. 12:155–163. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Hongming H and Jian H: Bortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6. Leuk Res. 33:115–122. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Tseng LM, Liu CY, Chang KC, Chu PY, Shiau CW and Chen KF: CIP2A is a target of bortezomib in human triple negative breast cancer cells. Breast Cancer Res. 14:R682012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bilir C, Engin H, Can M, Likhan S, Demirtas D, Kuzu F and Bayraktaroglu T: Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer. Oncol Lett 9: 2819-2824, 2015.
APA
Bilir, C., Engin, H., Can, M., Likhan, S., Demirtas, D., Kuzu, F., & Bayraktaroglu, T. (2015). Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer. Oncology Letters, 9, 2819-2824. https://doi.org/10.3892/ol.2015.3094
MLA
Bilir, C., Engin, H., Can, M., Likhan, S., Demirtas, D., Kuzu, F., Bayraktaroglu, T."Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer". Oncology Letters 9.6 (2015): 2819-2824.
Chicago
Bilir, C., Engin, H., Can, M., Likhan, S., Demirtas, D., Kuzu, F., Bayraktaroglu, T."Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer". Oncology Letters 9, no. 6 (2015): 2819-2824. https://doi.org/10.3892/ol.2015.3094
Copy and paste a formatted citation
x
Spandidos Publications style
Bilir C, Engin H, Can M, Likhan S, Demirtas D, Kuzu F and Bayraktaroglu T: Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer. Oncol Lett 9: 2819-2824, 2015.
APA
Bilir, C., Engin, H., Can, M., Likhan, S., Demirtas, D., Kuzu, F., & Bayraktaroglu, T. (2015). Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer. Oncology Letters, 9, 2819-2824. https://doi.org/10.3892/ol.2015.3094
MLA
Bilir, C., Engin, H., Can, M., Likhan, S., Demirtas, D., Kuzu, F., Bayraktaroglu, T."Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer". Oncology Letters 9.6 (2015): 2819-2824.
Chicago
Bilir, C., Engin, H., Can, M., Likhan, S., Demirtas, D., Kuzu, F., Bayraktaroglu, T."Increased serum tumor necrosis factor receptor-associated factor-6 expression in patients with non-metastatic triple-negative breast cancer". Oncology Letters 9, no. 6 (2015): 2819-2824. https://doi.org/10.3892/ol.2015.3094
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