Primary mediastinal giant liposarcoma with smooth muscle and neural differentiation: A case report

Ma,Jian; Zhang,Hong‑Mei; Zhang,Li‑Wang; Zheng,Min‑Wen; Yu,Min

doi:10.3892/ol.2015.3103

June-2015 Volume 9 Issue 6

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June-2015 Volume 9 Issue 6

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Case Report

Primary mediastinal giant liposarcoma with smooth muscle and neural differentiation: A case report

Authors:
- Jian Ma
- Hong‑Mei Zhang
- Li‑Wang Zhang
- Min‑Wen Zheng
- Min Yu
View Affiliations / Copyright

Affiliations: Department of Research, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China, Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China, Department of Radiology, Xijing Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Military Health Services, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China
Pages: 2667-2669
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Published online on: April 8, 2015

https://doi.org/10.3892/ol.2015.3103
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Abstract

Liposarcoma has previously been described in Western studies, however, such cases are rarely reported in the mediastinum. In addition, the presence of a liposarcoma with smooth muscle and neural differentiation has not been previously reported. Thus, the present study describes the rare case of a 28‑year‑old Chinese male admitted to our hospital with the symptoms of chest tightness and shortness of breath due to a recurrent fibrolipoma in the mediastinum. The resected tumor measured 23 cm at its largest diameter, with histopathological and immunohistochemical features indicating a well‑differentiated liposarcoma accompanied by smooth muscle and neural differentiation. Following the resection, the patient underwent radiation treatment and remains alive with no evidence of disease recurrence at two months post‑surgery. To the best of our knowledge, the present study is the first to report a case of liposarcoma with smooth muscle and neural differentiation, which indicates that liposarcomas could potentially originate from stem cells. The present study highlights the fact that pathologists must carefully investigate the histopathological characteristics of liposarcomas in order to obtain an accurate diagnosis.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary mediastinal giant liposarcoma with smooth muscle and neural differentiation: A case report

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