Surgical resection and post‑operative radiotherapy in an adult renal neuroblastoma patient with multiple bone and joint metastases: A case report
- Authors:
- Qiu‑Long Liu
- Qi‑Lian Liang
- Wen‑Ting Ou
- Zhou‑Yu Li
- Xiang‑Ning Zhang
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Affiliations: Department of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, P.R. China, Department of Radiotherapy, Cancer Center of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China, Department of Pathophysiology, School of Basic Medical Science, Guangdong Medical College, Dongguan, Guangdong 523808, P.R. China
- Published online on: April 9, 2015 https://doi.org/10.3892/ol.2015.3109
-
Pages:
2591-2594
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Abstract
Renal neuroblastoma is uncommon, particularly in adults, with only a few cases having been reported in studies published in the English language. The incidence is only 0.12 cases/1 million individuals in those aged >20 years. Studies of the pathogenesis, biological characteristics, treatment and prognosis of renal neuroblastoma are limited due to this low incidence. The present study reports the case of a 22‑year‑old adult female who was diagnosed with a left renal neuroblastoma by computed tomography (CT), bone scan and pathological examination. The patient underwent a left nephroureterectomy, ipsilateral lymph node dissection and post‑operative radiotherapy, prior to discharge 60 days after admittance. At the nine‑month follow‑up examination, the patient showed no evidence of recurrence, progression or metastatic disease on the CT scans of the chest, abdomen and pelvis. Renal neuroblastoma is extremely uncommon in adults. The diagnosis and treatment of renal neuroblastoma is complicated by the overall low incidence, lack of specific treatment guidelines, advanced disease state due to late presentation, and its associated co‑morbidities. Further study of the pathogenesis, biological and clinical characteristics, and treatment of renal neuroblastoma is required to provide an optimal treatment for patients and to improve the patient's quality of life.
View References
|
1
|
Franks LM, Bollen A, Seeger RC, et al:
Neuroblastoma in adults and adolescents: an indolent course with
poor survival. Cancer. 79:2028–2035. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Esiashvili N, Goodman M, Ward K, et al:
Neuroblastoma in adults: incidence and survival analysis based on
SEER data. Pediatric Blood Cancer. 49:41–46. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Bayrak O, Seckiner I, Erturhan S, et al:
Adult intrarenal neuroblastoma presenting as renal cell carcinoma.
Can Urol Assoc J. 6:E144–E146. 2012.PubMed/NCBI
|
|
4
|
Garnier S, Maillet O, Haouy S, et al:
Prenatal intrarenal neuroblastoma mimicking a mesoblastic nephroma:
a case report. J Pediatr Surg. 47:e21–e23. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Tiu A, Latif E, Yau L, et al: Primary
renal neuroblastoma in adults. Urology. 82:11–13. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Rabinowicz R, Barchana M, Liphshiz I, et
al: Cancer incidence and survival among infants in Israel,
1998–2007. Pediatr Hematol Oncol. 30:646–654. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Pugh TJ, Morozova O, Attiyeh EF, et al:
The genetic landscape of high-risk neuroblastoma. Nat Genet.
45:279–284. 2013. View
Article : Google Scholar : PubMed/NCBI
|
|
8
|
Polishchuk AL, Dubois SG, Haas-Kogan D, et
al: Response, survival and toxicity after
iodine-131-metaiodobenzylguanidine therapy for neuroblastoma in
pre-adolescents, adolescents and adults. Cancer. 117:4286–4293.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Serrano R, Rodriguez-Peralto JL, De Orbe
GG, et al: Intrarenal neuroblastoma diagnosed by fine-needle
aspiration: a report of two cases. Diagn Cytopathol. 27:294–297.
2002. View
Article : Google Scholar : PubMed/NCBI
|
|
10
|
Gains JE, Bomanji JB, Fersht NL, et al:
177Lu-DOTATATE molecular radiotherapy for childhood neuroblastoma.
J Nucl Med. 52:1041–1047. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Gohji K, Nakanishi T, Hara I, et al: Two
cases of primary neuroblastoma of the kidney in adults. J Urol.
137:966–968. 1987.PubMed/NCBI
|
|
12
|
Moreno L, Vaidya SJ, Pinkerton CR, et al:
European neuroblastoma study group; Children's Cancer and Leukaemia
Group (CCLG) (formerly UKCCSG): Long-term follow-up of children
with high-risk neuroblastoma: the ENSG5 trial experience. Pediatr
Blood Cancer. 60:1135–1140. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Perwein T, Lackner H, Sovinz P, et al:
Survival and late effects in children with stage 4 neuroblastoma.
Pediatr Blood Cancer. 57:629–635. 2011. View Article : Google Scholar : PubMed/NCBI
|
