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Article

Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis

  • Authors:
    • Jun Liang
    • Wei‑Feng Wang
    • Shao Xie
    • Xian‑Li Zhang
    • Wei‑Feng Qi
    • Xiu‑Ping Zhou
    • Jin‑Xia Hu
    • Qiong Shi
    • Ru‑Tong Yu
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China, Laboratory of Neurosurgery, Xuzhou Medical College, Xuzhou, Jiangsu 221002, P.R. China
  • Pages: 2651-2656
    |
    Published online on: April 14, 2015
       https://doi.org/10.3892/ol.2015.3113
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Abstract

β-transducin repeat‑containing E3 ubiquitin protein ligase (β-TrCP) targets a number of substrates essential for specific aspects of tumorigenesis. In addition, β‑TrCP regulates various important signaling pathways. As β‑TrCP is involved in regulating the ubiquitination and degradation of multiple oncogenes and tumor suppressors, the function of β‑TrCP varies between cancer types. At present, the association between β‑TrCP expression and clinicopathological factors in glioma is unknown. Therefore, the current study used western blotting and immunohistochemistry to investigate the expression of β‑TrCP protein in glioma tissue specimens. It was identified that β‑TrCP protein expression levels were significantly lower in glioma compared with non‑tumorous human brain tissues. Furthermore, the higher the grade of glioma, the lower the level of β‑TrCP expression. Kaplan‑Meier analysis demonstrated that patients with low β‑TrCP expression experienced significantly worse overall survival compared with patients with high β‑TrCP expression. The results indicate that downregulation of β‑TrCP may be associated with poor survival in patients with glioma. Together, the current data indicates that β-TrCP may be applied as a useful indicator of glioma prognosis and may serve as an anticancer therapeutic target for glioma, however further investigation is required.
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1 

Wen PY and Kesari S: Malignant gliomas in adults. N Engl J Med. 359:492–507. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Buonerba C, Di Lorenzo G, Marinelli A, et al: A comprehensive outlook on intracerebral therapy of malignant gliomas. Crit Rev Oncol Hematol. 80:54–68. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Sherman JH, Hoes K, Marcus J, Komotar RJ, Brennan CW and Gutin PH: Neurosurgery for brain tumors: update on recent technical advances. Curr Neurol Neurosci Rep. 11:313–319. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Onishi M, Ichikawa T, Kurozumi K and Date I: Angiogenesis and invasion in glioma. Brain Tumor Pathol. 28:13–24. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Kim CS, Jung S, Jung TY, Jang WY, Sun HS and Ryu HH: Characterization of invading glioma cells using molecular analysis of leading-edge tissue. J Korean Neurosurg Soc. 50:157–165. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Ohgaki H and Kleihues P: Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol. 64:479–489. 2005.PubMed/NCBI

7 

Rutka JT, Taylor M, Mainprize T, Langlois A, Ivanchuk S, Mondal S and Dirks P: Molecular biology and neurosurgery in the third millennium. Neurosurgery. 46:1034–1051. 2000. View Article : Google Scholar : PubMed/NCBI

8 

DeSalle LM and Pagano M: Regulation of the G1 to S transition by the ubiquitin pathway. FEBS Lett. 490:179–189. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Pickart CM: Mechanisms underlying ubiquitination. Annu Rev Biochem. 70:503–533. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Ciechanover A, Orian A and Schwartz AL: Ubiquitin-mediated proteolysis: biological regulation via destruction. BioEssays. 22:442–451. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Zhou P: Targeted protein degradation. Curr Opin Chem Biol. 9:51–55. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Hershko A and Ciechanover A: The ubiquitin system. Annu Rev Biochem. 67:425–479. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Maniatis T: A ubiquitin ligase complex essential for the NF-kappaB, Wnt/Wingless and Hedgehog signaling pathways. Genes Dev. 13:505–510. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Liu C, Kato Y, Zhang Z, Do VM, Yankner BA and He X: beta-Trcp couples beta-catenin phosphorylation-degradation and regulates Xenopus axis formation. Proc Natl Acad Sci USA. 96:6273–6278. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Busino L, Donzelli M, Chiesa M, et al: Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature. 426:87–91. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T and Osada H: M-phase kinases induce phospho-dependent ubiquitination of somatic Weel by SCFbeta-TrCP. Proc Natl Acad Sci USA. 101:4419–4424. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Sahasrabuddhe AA, Dimri M, Bommi PV and Dimri GP: βTrCP regulates BMI1 protein turnover via ubiquitination and degradation. Cell Cycle. 10:1322–1330. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Fuchs SY, Chen A, Xiong Y, Pan ZQ and Ronai Z: HOS, a human homolog of Slimb, forms an SCF complex with Skp1 and Cullin1 and targets the phosphorylation-dependent degradation of IkappaB and beta-catenin. Oncogene. 18:2039–2046. 1999. View Article : Google Scholar : PubMed/NCBI

19 

Hart M, Concordet JP, Lassot I, et al: The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell. Curr Biol. 9:207–210. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Latres E, Chiaur DS and Pagano M: The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin. Oncogene. 18:849–854. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD and Jackson PK: Prophase destruction of Emi1 by the SCF (betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Dev Cell. 4:813–826. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Lang V, Janzen J, Fischer GZ, et al: betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932. Mol Cell Biol. 23:402–413. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Zhong J, Shaik S, Wan L, et al: SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration. Oncotarget. 4:2339–2353. 2013.PubMed/NCBI

24 

Shaik S, Nucera C, Inuzuka H, et al: SCF (β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2. J Exp Med. 209:1289–1307. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Wan M, Huang J, Jhala NC, et al: SCF(beta-TrCP1) controls Smad4 protein stability in pancreatic cancer cells. Am J Pathol. 166:1379–1392. 2005. View Article : Google Scholar : PubMed/NCBI

26 

He N, Li C, Zhang X, et al: Regulation of lung cancer cell growth and invasiveness by beta-TRCP. Mol Carcinog. 42:18–28. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Peus D, Newcomb N and Hofer S: Appraisal of the Karnofsky Performance Status and proposal of a simple algorithmic system for its evaluation. BMC Med Inform Decis Mak. 13:722013. View Article : Google Scholar : PubMed/NCBI

28 

Rosenblum MK: The 2007 WHO Classification of Nervous System Tumors: newly recognized members of the mixed glioneuronal group. Brain Pathol. 17:308–313. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Scherer DC, Brockman JA, Chen Z, Maniatis T and Ballard DW: Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci USA. 92:11259–11263. 1995. View Article : Google Scholar : PubMed/NCBI

30 

Gao G, Kun T, Sheng Y, et al: SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells. Mol Biol Rep. 40:2947–2953. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Gluschnaider U, Hidas G, Cojocaru G, Yutkin V, Ben-Neriah Y and Pikarsky E: beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor. PLoS One. 5:e90602010. View Article : Google Scholar : PubMed/NCBI

32 

Tang W, Li Y, Yu D, Thomas-Tikhonenko A, Spiegelman VS and Fuchs SY: Targeting beta-transducin repeat-containing protein E3 ubiquitin ligase augments the effects of antitumor drugs on breast cancer cells. Cancer Res. 65:1904–1908. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Ougolkov A, Zhang B, Yamashita K, et al: Associations among beta-TrCP, an E3 ubiquitin ligase receptor, beta-catenin and NF-kappaB in colorectal cancer. J Natl Cancer Inst. 96:1161–1170. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Warfel NA, Niederst M, Stevens MW, Brennan PM, Frame MC and Newton AC: Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt. J Biol Chem. 286:19777–19788. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Wu Z, Wang Q, Wang L, et al: Combined aberrant expression of Bmi1 and EZH2 is predictive of poor prognosis in glioma patients. J Neurol Sci. 335:191–196. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Tu Y, Gao X, Li G, et al: MicroRNA-218 inhibits glioma invasion, migration, proliferation and cancer stem-like cell self-renewal by targeting the polycomb group gene Bmi1. Cancer Res. 73:6046–6055. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Vlachostergios PJ and Papandreou CN: The Bmi-1/NF-ĸB/VEGF story: another hint for proteasome involvement in glioma angiogenesis? J Cell Commun Signal. 7:235–237. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Li Y, Hu J, Guan F, et al: Copper induces cellular senescence in human glioblastoma multiforme cells through downregulation of Bmi-1. Oncol Rep. 29:1805–1810. 2013.PubMed/NCBI

39 

Jiang L, Song L, Wu J, et al: Bmi-1 promotes glioma angiogenesis by activating NF-ĸB signaling. PLoS One. 8:e555272013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liang J, Wang WF, Xie S, Zhang XL, Qi WF, Zhou XP, Hu JX, Shi Q and Yu RT: Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis. Oncol Lett 9: 2651-2656, 2015.
APA
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X. ... Yu, R. (2015). Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis. Oncology Letters, 9, 2651-2656. https://doi.org/10.3892/ol.2015.3113
MLA
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X., Hu, J., Shi, Q., Yu, R."Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis". Oncology Letters 9.6 (2015): 2651-2656.
Chicago
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X., Hu, J., Shi, Q., Yu, R."Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis". Oncology Letters 9, no. 6 (2015): 2651-2656. https://doi.org/10.3892/ol.2015.3113
Copy and paste a formatted citation
x
Spandidos Publications style
Liang J, Wang WF, Xie S, Zhang XL, Qi WF, Zhou XP, Hu JX, Shi Q and Yu RT: Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis. Oncol Lett 9: 2651-2656, 2015.
APA
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X. ... Yu, R. (2015). Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis. Oncology Letters, 9, 2651-2656. https://doi.org/10.3892/ol.2015.3113
MLA
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X., Hu, J., Shi, Q., Yu, R."Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis". Oncology Letters 9.6 (2015): 2651-2656.
Chicago
Liang, J., Wang, W., Xie, S., Zhang, X., Qi, W., Zhou, X., Hu, J., Shi, Q., Yu, R."Expression of β-transducin repeat-containing E3 ubiquitin protein ligase in human glioma and its correlation with prognosis". Oncology Letters 9, no. 6 (2015): 2651-2656. https://doi.org/10.3892/ol.2015.3113
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