|
1
|
Cunningham D, Atkin W, Lenz HJ, Lynch HT,
Minsky B, Nordlinger B and Starling N: Colorectal cancer. Lancet.
375:1030–1047. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Weitz J, Koch M, Debus J, Höhler T, Galle
PR and Büchler MW: Colorectal cancer. Lancet. 365:153–165. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Visvader JE and Lindeman GJ: Cancer stem
cells in solid tumours: Accumulating evidence and unresolved
questions. Nat Rev Cancer. 8:755–768. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Odoux C, Fohrer H, Hoppo T, et al: A
stochastic model for cancer stem cell origin in metastatic colon
cancer. Cancer Res. 68:6932–6941. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Wu XS, Xi HQ and Chen L: Lgr5 is a
potential marker of colorectal carcinoma stem cells that correlates
with patient survival. World J Surg Oncol. 10:2442012. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Lobo NA, Shimono Y, Qian D and Clarke MF:
The biology of cancer stem cells. Annu Rev Cell Dev Biol.
23:675–699. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Barker N, van Es JH, Kuipers J, et al:
Identification of stem cells in small intestine and colon by marker
gene Lgr5. Nature. 449:1003–1007. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Barker N, Ridgway RA, van Es JH, et al:
Crypt stem cells as the cells-of-origin of intestinal cancer.
Nature. 457:608–611. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
McDonald T, Wang R, Bailey W, et al:
Identification and cloning of an orphan G protein-coupled receptor
of the glycoprotein hormone receptor subfamily. Biochem Biophys Res
Commun. 247:266–270. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Hsu SY, Liang SG and Hsueh AJ:
Characterization of two LGR genes homologous to gonadotropin and
thyrotropin receptors with extracellular leucine-rich repeats and a
G protein-coupled, seven-transmembrane region. Mol Endocrinol.
12:1830–1845. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Van der Flier LG, Sabates-Bellver J, Oving
I, et al: The intestinal Wnt/TCF signature. Gastroenterology.
132:628–632. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Carmon KS, Gong X, Lin Q, et al:
R-spondins function as ligands of the orphan receptors LGR4 and
LGR5 to regulate Wnt/beta-catenin signaling. Proc Natl Acad Sci
USA. 108:11452–11457. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
de Lau W, Barker N, Low TY, et al: Lgr5
homologues associate with Wnt receptors and mediate R-spondin
signalling. Nature. 476:293–297. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Early DS, Fontana L and Davidson NO:
Translational approaches to addressing complex genetic pathways in
colorectal cancer. Transl Res. 151:10–16. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
MacDonald BT, Tamai K and He X:
Wnt/beta-catenin signaling: Components, mechanisms and diseases.
Dev Cell. 17:9–26. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Cadigan KM and Peifer M: Wnt signaling
from development to disease: Insights from model systems. Cold
Spring Harb Perspect Biol. 1:a0028812009. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Schneikert J and Behrens J: The canonical
Wnt signalling pathway and its APC partner in colon cancer
development. Gut. 56:417–425. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Clevers H and Nusse R: Wnt/β-catenin
signaling and disease. Cell. 149:1192–1205. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Metcalfe C and Bienz M: Inhibition of GSK3
by Wnt signalling - two contrasting models. J Cell Sci.
124:3537–3544. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Brabletz T, Hlubek F, Spaderna S, et al:
Invasion and metastasis in colorectal cancer:
epithelial-mesenchymal transition, mesenchymal: Epithelial
transition, stem cells and β-catenin. Cells Tissues Organs.
179:56–65. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Morin PJ and Weeraratna AT: Wnt signaling
in human cancer. Cancer Treat Res. 115:169–187. 2003.PubMed/NCBI
|
|
22
|
Taketo MM: Shutting down Wnt
signal-activated cancer. Nat Genet. 36:320–322. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Yamamoto Y, Sakamoto M, Fujii G, et al:
Overexpression of orphan G-protein-coupled receptor, Gpr49, in
human hepatocellular carcinomas with beta-catenin mutations.
Hepatology. 37:528–533. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
McClanahan T, Koseoglu S, Smith K, et al:
Identification of overexpression of orphan G protein-coupled
receptor GPR49 in human colon and ovarian primary tumors. Cancer
Biol Ther. 5:419–426. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Carmon KS, Lin Q, Gong X, et al: LGR5
interacts and cointernalizes with Wnt receptors to modulate
Wnt/β-catenin signaling. Mol Cell Biol. 32:2054–2064. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Al-Kharusi MR, Smartt HJ, Greenhough A, et
al: LGR5 promotes survival in human colorectal adenoma cells and is
upregulated by PGE2: Implications for targeting adenoma stem cells
with NSAIDs. Carcinogenesis. 34:1150–1157. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Garcia MI, Ghiani M, Lefort A, et al: LGR5
deficiency deregulates Wnt signaling and leads to precocious Paneth
cell differentiation in the fetal intestine. Dev Biol. 331:58–67.
2009. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Uchida H, Yamazaki K, Fukuma M, et al:
Overexpression of leucine-rich repeat-containing G protein-coupled
receptor 5 in colorectal cancer. Cancer Sci. 101:1731–1737. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Takahashi H, Ishii H, Nishida N, et al:
Significance of Lgr5(+ve) cancer stem cells in the colon and
rectum. Ann Surg Oncol. 18:1166–1174. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Yang M, Zhong WW and Srivastava N: G
protein-coupled lysophosphatidic acid receptors stimulate
proliferation of colon cancer cells through the {beta}-catenin
pathway. Proc Natl Acad Sci USA. 102:6027–6032. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Hsu HC, Liu YS, Tseng KC, et al:
Overexpression of Lgr5 correlates with resistance to 5-FU-based
chemotherapy in colorectal cancer. Int J Colorectal Dis.
28:1535–1546. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Hirsch D, Barker N, McNeil N, et al: LGR5
positivity defines stem-like cells in colorectal cancer.
Carcinogenesis. 35:849–858. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Walker F, Zhang HH, Odorizzi A and Burgess
AW: LGR5 is a negative regulator of tumourigenicity, antagonizes
Wnt signalling and regulates cell adhesion in colorectal cancer
cell lines. PLoS One. 6:e227332011. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Tanese K, Fukuma M, Yamada T, et al:
G-protein-coupled receptor GPR49 is up-regulated in basal cell
carcinoma and promotes cell proliferation and tumor formation. Am J
Pathol. 173:835–843. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Fan XS, Wu HY, Yu HP, et al: Expression of
Lgr5 in human colorectal carcinogenesis and its potential
correlation with beta-catenin. Int J Colorectal Dis. 25:583–590.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Scannell CA, Pedersen EA, Mosher JT, et
al: LGR5 is expressed by Ewing sarcoma and potentiates
Wnt/β-catenin signaling. Front Oncol. 3:812013. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Wang D, Zhou J, Fan C, et al: Knockdown of
LGR5 suppresses the proliferation of glioma cells in vitro and in
vivo. Oncol Rep. 31:41–49. 2014.PubMed/NCBI
|
