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Article

Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws

  • Authors:
    • Meral Günaldi
    • Cigdem Usul Afsar
    • Berna Bozkurt Duman
    • Ismail Oguz Kara
    • Ufuk Tatli
    • Berksoy Sahi̇n
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey, Department of Medical Oncology, Cukurova University Medical School, Adana, Adana, Turkey, Department of Medical Oncology, Adana Research and Training Hospital, Adana, Adana, Turkey, Faculty of Dentistry, Cukurova University, Adana, Adana, Turkey
  • Pages: 439-442
    |
    Published online on: April 27, 2015
       https://doi.org/10.3892/ol.2015.3156
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Abstract

Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe bone disease for which the pathogenetic mechanisms and risk factors are not fully understood. The present study evaluated the data of 652 patients with bone metastasis that had undergone treatment with biphosphonates. Subsequently, 24 patients with BRONJ and 20 control patients without BRONJ that were treated with zoledronic acid were enrolled. It was found that BRONJ occurred in 3.6% of patients. The mean age and the administration of dental treatment were found to be significantly associated with BRONJ development (P=0.049 and P=0.013, respectively). The cumulative dose median in the BRONJ group was found to be significantly higher compared with the cumulative dose average in the control group (P=0.037). In addition, at the time of BRONJ development, improvement in the disease was determined to be better in the BRONJ group than in the control group (P=0.031). The present study determined that age, the existence of dental extraction and the cumulative dose of zoledronate were all important risk factors in BRONJ development.
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Copy and paste a formatted citation
Spandidos Publications style
Günaldi M, Afsar CU, Duman BB, Kara IO, Tatli U and Sahi̇n B: Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws. Oncol Lett 10: 439-442, 2015.
APA
Günaldi, M., Afsar, C.U., Duman, B.B., Kara, I.O., Tatli, U., & Sahi̇n, B. (2015). Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws. Oncology Letters, 10, 439-442. https://doi.org/10.3892/ol.2015.3156
MLA
Günaldi, M., Afsar, C. U., Duman, B. B., Kara, I. O., Tatli, U., Sahi̇n, B."Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws". Oncology Letters 10.1 (2015): 439-442.
Chicago
Günaldi, M., Afsar, C. U., Duman, B. B., Kara, I. O., Tatli, U., Sahi̇n, B."Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws". Oncology Letters 10, no. 1 (2015): 439-442. https://doi.org/10.3892/ol.2015.3156
Copy and paste a formatted citation
x
Spandidos Publications style
Günaldi M, Afsar CU, Duman BB, Kara IO, Tatli U and Sahi̇n B: Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws. Oncol Lett 10: 439-442, 2015.
APA
Günaldi, M., Afsar, C.U., Duman, B.B., Kara, I.O., Tatli, U., & Sahi̇n, B. (2015). Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws. Oncology Letters, 10, 439-442. https://doi.org/10.3892/ol.2015.3156
MLA
Günaldi, M., Afsar, C. U., Duman, B. B., Kara, I. O., Tatli, U., Sahi̇n, B."Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws". Oncology Letters 10.1 (2015): 439-442.
Chicago
Günaldi, M., Afsar, C. U., Duman, B. B., Kara, I. O., Tatli, U., Sahi̇n, B."Effect of the cumulative dose of zoledronic acid on the pathogenesis of osteonecrosis of the jaws". Oncology Letters 10, no. 1 (2015): 439-442. https://doi.org/10.3892/ol.2015.3156
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