Resection and reconstruction of giant cervical metastatic cancer using a pectoralis major muscular flap transfer: A prospective study of 16 patients

Zhang,Xiangmin; Liu,Folin; Lan,Xiaolin; Huang,Jing; Luo,Keqing; Li,Shaojin

doi:10.3892/ol.2015.3158

July-2015 Volume 10 Issue 1

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July-2015 Volume 10 Issue 1

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Article

Resection and reconstruction of giant cervical metastatic cancer using a pectoralis major muscular flap transfer: A prospective study of 16 patients

Authors:
- Xiangmin Zhang
- Folin Liu
- Xiaolin Lan
- Jing Huang
- Keqing Luo
- Shaojin Li
View Affiliations / Copyright

Affiliations: Department of Head and Neck, Tumor Hospital of Ganzhou, Ganzhou, Jiangxi, P.R. China, Institute of Cancer Research, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, P.R. China, Ganzhou Institute of Cancer Research, Ganzhou, Jiangxi, P.R. China
Pages: 372-378
|
Published online on: April 28, 2015

https://doi.org/10.3892/ol.2015.3158
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Abstract

If not promptly or properly treated, certain cervical metastatic cancers that develop from unknown primary tumors may rapidly grow into giant tumors that can invade the blood vessels, muscle and skin. The present study examined the feasibility and efficacy of radical neck dissection combined with reconstruction using the pectoralis major myocutaneous flap for the treatment of giant cervical metastatic cancers that have developed from unknown primary tumors and have invaded the skin. A total of 16 patients who met the inclusion criteria were subjected to radical neck dissection to adequately resect invaded skin, and the pectoralis major myocutaneous flap was used to repair the large skin defect created in the cervical region. Following the surgery, the patients received concurrent chemoradiotherapy. The pectoralis major myocutaneous flap survived in all 16 patients, with no cases of flap necrosis. In addition, no post‑operative lymphedema, paresthesia or dysfunction of an upper extremity occurred due to the cutting of a pectoralis major muscle. In 9 cases, patients were satisfied with their post‑operative shoulder movement at the donor site; in the remaining 7 cases, patients felt greater weakness in this region following surgery relative to prior to surgery. The 14 male patients were generally satisfied with the post‑operative appearance of the donor region, whereas the 2 female patients were dissatisfied with the appearance of this region. Follow‑up for 6‑53 months after the patients were discharged following surgery and chemotherapy revealed that the recurrence of cervical tumors in 6 cases. Overall, radical neck dissection combined with the use of the pectoralis major myocutaneous flap for reconstruction is a feasible approach for the treatment of giant cervical metastatic cancers that have developed from unknown primary tumors and have invaded the skin. Post‑operative concurrent chemoradiotherapy should be administered to improve the local control rate and patient quality of life, allowing a satisfactory therapeutic efficacy to be achieved.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Resection and reconstruction of giant cervical metastatic cancer using a pectoralis major muscular flap transfer: A prospective study of 16 patients

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