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Case Report Open Access

Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes

  • Authors:
    • Shogo Tajima
    • Michihiko Aki
    • Kiyoshige Yajima
    • Tsuyoshi Takahashi
    • Hiroshi Neyatani
    • Kenji Koda
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Shizuoka Saiseikai General Hospital, Shizuoka, Shizuoka 422-8021, Japan, Department of Cell Biology and Anatomy, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431-3192, Japan, Department of Chest Surgery, Fujieda Municipal General Hospital, Fujieda, Shizuoka 426-0077, Japan, Department of Pathology, Fujieda Municipal General Hospital, Fujieda, Shizuoka 426-0077, Japan
    Copyright: © Tajima et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 175-181
    |
    Published online on: April 30, 2015
       https://doi.org/10.3892/ol.2015.3169
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Abstract

Primary salivary gland-type tumors of the lung are rare; among them, epithelial‑myoepithelial carcinomas (EMC) represent a minor histological subtype. The present case documents an EMC that occluded the B8 segment of the left lung in a 72‑year‑old woman. Macroscopically, the tumor was well‑demarcated; however, microscopic examination demonstrated that it had infiltrated the lung parenchyma. The majority of the tumor mass was composed of a myoepithelial overgrowth in conjunction with conventional bilayered ductal structures comprising epithelial and myoepithelial cells. At the advancing edge of the tumor, the myoepithelial overgrowth was observed to be gradually transitioning to a higher‑grade component, which demonstrated venous invasion. The Ki‑67 labeling index was reduced compared with high‑grade transformation (HGT) of salivary gland EMC; p53 was sparsely observed on immunostaining. However, cyclin D1, which is reported to be overexpressed in certain subtypes of salivary gland carcinomas with HGT, was overexpressed in the higher‑grade component of the tumor, indicating a potential HGT initiation. The surgical margin was tumor free, and no recurrence has been observed for 4 months. A thorough follow‑up is required considering the HGT‑like changes and venous invasion of the tumor. Additional studies are required to elucidate the characteristics of pulmonary EMC, with an emphasis on detecting HGT or HGT‑like changes.
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View References

1 

Kang DY, Yoon YS, Kim HK, et al: Primary salivary gland-type lung cancer: surgical outcomes. Lung Cancer. 72:250–254. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Zhu F, Liu Z, Hou Y, et al: Primary salivary gland-type lung cancer: clinicopathological analysis of 88 cases from China. J Thorac Oncol. 8:1578–1584. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Song DH, Choi IH, Ha SY, et al: Epithelial-myoepthelial carcinoma of the tracheobronchial tree: the prognostic role of myoepithelial cells. Lung Cancer. 83:416–419. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Donath K, Seifert G and Schmitz R: Diagnosis and ultrastructure of the tubular carcinoma of salivary gland ducts. Epithelial-myoepithelial carcinoma of the intercalated ducts. Virchows Arch A Pathol Pathol Anat. 356:16–31. 1972.(In German). View Article : Google Scholar : PubMed/NCBI

5 

Fonseca I and Soares J: Epithelial-myoepithelial carcinomaWorld Health Organization Classification of Tumours: Pathology and Genetics of Head and Neck Tumours. Barnes L, Eveson JW, Reichart P and Sidransky D: 3rd. IARC Press; Lyon, France: pp. 225–226. 2005

6 

Corio RL, Sciubba JJ, Brannon RB and Batsakis JG: Epithelial-myoepithelial carcinoma of intercalated duct origin. A clinicopathologic and ultrastructural assessment of sixteen cases. Oral Surg Oral Med Oral Pathol. 53:280–287. 1982. View Article : Google Scholar : PubMed/NCBI

7 

Moran CA: Primary salivary gland-type tumors of the lung. Semin Diagn Pathol. 12:106–122. 1995.PubMed/NCBI

8 

Pelosi G, Fraggetta F, Maffini F, Solli P, Cavallon A and Viale G: Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature. Mod Pathol. 14:521–526. 2001. View Article : Google Scholar : PubMed/NCBI

9 

Nguyen CV, Suster S and Moran CA: Pulmonary epithelial-myoepithelial carcinoma: a clinicopathologic and immunohistochemical study of 5 cases. Hum Pathol. 40:366–373. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Nagao T: “Dedifferentiation” and high-grade transformation in salivary gland carcinomas. Head Neck Pathol. 7:(Suppl 1). S37–S47. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Seethala RR, Barnes EL and Hunt JL: Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 31:44–57. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Costa AF, Altemani A and Hermsen M: Current concepts on dedifferentiation/high-grade transformation in salivary gland tumors. Patholog Res Int. 2011:3259652011.PubMed/NCBI

13 

Baker AR, Ohanessian SE, Adil E, Crist HS, Goldenberg D and Mani H: Dedifferentiated epithelial-myoepithelial carcinoma: analysis of a rare entity based on a case report and literature review. Int J Surg Pathol. 21:514–519. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Arif F, Wu S, Andaz S and Fox S: Primary epithelial myoepithelial carcinoma of lung, reporting of a rare entity, its molecular histogenesis and review of the literature. Rep pathol. 2012:3194342012.

15 

Yang S and Chen X: Epithelial-myoepithelial carcinoma with high grade transformation. Int J Oral Maxillofac Surg. 41:810–813. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Henley JD, Geary WA, Jackson CL, Wu CD and Gnepp DR: Dedifferentiated acinic cell carcinoma of the parotid gland: A distinct rarely described entity. Hum Pathol. 28:869–873. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Di Palma S, Corletto V, Lavarino C, Birindelli S and Pilotti S: Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland. Virchows Arch. 434:361–365. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Casimiro MC and Pestell RG: Cyclin d1 induces chromosomal instability. Oncotarget. 3:224–225. 2012.PubMed/NCBI

19 

Casimiro MC, Crosariol M, Loro E, et al: ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice. J Clin Invest. 122:833–843. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Roy P, Bullock MJ, Perez-Ordoñez B, Dardick I and Weinreb I: Epithelial-myoepithelial carcinoma with high grade transformation. Am J Surg Pathol. 34:1258–1265. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Cheuk W and Chan JK: Advances in salivary gland pathology. Histopathology. 51:1–20. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Cho KJ, el-Naggar AK, Ordonez NG, Luna MA, Austin J and Batsakis JG: Epithelial-myoepithelial carcinoma of salivary glands. A clinicopathologic, DNA flow cytometric, and immunohistochemical study of Ki-67 and HER-2/neu oncogene. Am J Clin Pathol. 103:432–437. 1995.PubMed/NCBI

23 

Luna MA, Ordonez NG, Mackay B, Batsakis JG and Guillamondegui O: Salivary epithelial-myoepithelial carcinomas of intercalated ducts: a clinical, electron microscopic, and immunocytochemical study. Oral Surg Oral Med Oral Pathol. 59:482–490. 1985. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Tajima S, Aki M, Yajima K, Takahashi T, Neyatani H and Koda K: Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes. Oncol Lett 10: 175-181, 2015.
APA
Tajima, S., Aki, M., Yajima, K., Takahashi, T., Neyatani, H., & Koda, K. (2015). Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes. Oncology Letters, 10, 175-181. https://doi.org/10.3892/ol.2015.3169
MLA
Tajima, S., Aki, M., Yajima, K., Takahashi, T., Neyatani, H., Koda, K."Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes". Oncology Letters 10.1 (2015): 175-181.
Chicago
Tajima, S., Aki, M., Yajima, K., Takahashi, T., Neyatani, H., Koda, K."Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes". Oncology Letters 10, no. 1 (2015): 175-181. https://doi.org/10.3892/ol.2015.3169
Copy and paste a formatted citation
x
Spandidos Publications style
Tajima S, Aki M, Yajima K, Takahashi T, Neyatani H and Koda K: Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes. Oncol Lett 10: 175-181, 2015.
APA
Tajima, S., Aki, M., Yajima, K., Takahashi, T., Neyatani, H., & Koda, K. (2015). Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes. Oncology Letters, 10, 175-181. https://doi.org/10.3892/ol.2015.3169
MLA
Tajima, S., Aki, M., Yajima, K., Takahashi, T., Neyatani, H., Koda, K."Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes". Oncology Letters 10.1 (2015): 175-181.
Chicago
Tajima, S., Aki, M., Yajima, K., Takahashi, T., Neyatani, H., Koda, K."Primary epithelial-myoepithelial carcinoma of the lung: A case report demonstrating high-grade transformation-like changes". Oncology Letters 10, no. 1 (2015): 175-181. https://doi.org/10.3892/ol.2015.3169
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