Role of microRNA-150 in solid tumors (Review)

  • Authors:
    • Fang Wang
    • Xiubao Ren
    • Xinwei Zhang
  • View Affiliations

  • Published online on: April 30, 2015     https://doi.org/10.3892/ol.2015.3170
  • Pages: 11-16
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRNAs) are a family of small endogenous noncoding RNAs and their altered expression has been associated with various cellular functions, including cell development, proliferation, differentiation, apoptosis, signal transduction, tumorigenesis and cancer progression. Accumulating evidence has indicated that miRNA (miR)‑150 plays an essential regulatory role in normal hematopoiesis and tumorigenesis; therefore, miR‑150 may be a potential biomarker and therapeutic target in the diagnosis and treatment of various malignancies. The aim of the present review was to summarize the current knowledge on the functions and regulatory mechanism of miR‑150 as an oncogene or tumor suppressor gene in solid tumors. In addition, its potential application as a tumor biomarker, targeted therapeutic strategy and index of prognosis in various cancer types was investigated.
View Figures
View References

Related Articles

Journal Cover

July-2015
Volume 10 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang F, Ren X and Zhang X: Role of microRNA-150 in solid tumors (Review). Oncol Lett 10: 11-16, 2015
APA
Wang, F., Ren, X., & Zhang, X. (2015). Role of microRNA-150 in solid tumors (Review). Oncology Letters, 10, 11-16. https://doi.org/10.3892/ol.2015.3170
MLA
Wang, F., Ren, X., Zhang, X."Role of microRNA-150 in solid tumors (Review)". Oncology Letters 10.1 (2015): 11-16.
Chicago
Wang, F., Ren, X., Zhang, X."Role of microRNA-150 in solid tumors (Review)". Oncology Letters 10, no. 1 (2015): 11-16. https://doi.org/10.3892/ol.2015.3170