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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-2015 Volume 10 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Review

Targeted therapy against cancer stem cells (Review)

  • Authors:
    • Tao Yang
    • Kiera Rycaj
  • View Affiliations / Copyright

    Affiliations: Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China, Department of Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
  • Pages: 27-33
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    Published online on: May 4, 2015
       https://doi.org/10.3892/ol.2015.3172
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Abstract

Research into cancer stem cells (CSCs), which have the ability to self-renew and give rise to more mature (differentiated) cancer cells, and which may be the cells responsible for the overall organization of a tumor, has progressed rapidly and concomitantly with recent advances in studies of normal tissue stem cells. CSCs have been reported in a wide spectrum of human tumors. Like normal tissue stem cells, CSCs similarly exhibit significant phenotypic and functional heterogeneity. The ability of CSCs to self‑renew results in the immortality of malignant cells at the population level, whereas the ability of CSCs to differentiate, either fully or partially, generates the cellular hierarchy and heterogeneity commonly observed in solid tumors. CSCs also appear to have maximized their pro‑survival mechanisms leading to their relative resistance to anti‑cancer therapies and subsequent relapse. Studies in animal models of human cancers have also provided insight into the heterogeneity and characteristics of CSCs, helping to establish a platform for the development of novel targeted therapies against specific CSCs. In the present study, we briefly review the most recent progress in dissecting CSC heterogeneity and targeting CSCs in various human tumor systems. We also highlight a few examples of CSC‑targeted drug development and clinical trials, with the ultimate aim of developing more effective therapeutic regimens that are capable of preventing tumor recurrence and metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Yang T and Rycaj K: Targeted therapy against cancer stem cells (Review). Oncol Lett 10: 27-33, 2015.
APA
Yang, T., & Rycaj, K. (2015). Targeted therapy against cancer stem cells (Review). Oncology Letters, 10, 27-33. https://doi.org/10.3892/ol.2015.3172
MLA
Yang, T., Rycaj, K."Targeted therapy against cancer stem cells (Review)". Oncology Letters 10.1 (2015): 27-33.
Chicago
Yang, T., Rycaj, K."Targeted therapy against cancer stem cells (Review)". Oncology Letters 10, no. 1 (2015): 27-33. https://doi.org/10.3892/ol.2015.3172
Copy and paste a formatted citation
x
Spandidos Publications style
Yang T and Rycaj K: Targeted therapy against cancer stem cells (Review). Oncol Lett 10: 27-33, 2015.
APA
Yang, T., & Rycaj, K. (2015). Targeted therapy against cancer stem cells (Review). Oncology Letters, 10, 27-33. https://doi.org/10.3892/ol.2015.3172
MLA
Yang, T., Rycaj, K."Targeted therapy against cancer stem cells (Review)". Oncology Letters 10.1 (2015): 27-33.
Chicago
Yang, T., Rycaj, K."Targeted therapy against cancer stem cells (Review)". Oncology Letters 10, no. 1 (2015): 27-33. https://doi.org/10.3892/ol.2015.3172
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