Extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 overexpression is associated with loss of hormone receptor expression and poor prognosis in endometrial cancer

  • Authors:
    • Yuan Yuan
    • Ning Shen
    • Shu‑Yan Yang
    • Ling Zhao
    • Yong‑Mei Guan
  • View Affiliations

  • Published online on: May 6, 2015     https://doi.org/10.3892/ol.2015.3177
  • Pages: 342-348
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Abstract

Extracellular matrix metalloproteinase inducer (CD147) and matrix metalloproteinase‑2 (MMP‑2) have been documented in various malignancies. CD147 is a member of the immunoglobulin superfamily, which promotes the production and release of MMPs in mesenchymal cells and tumor cells. MMP‑2 has been extensively studied and is considered to be particularly important in cancer invasion and metastasis. However, studies investigating the expression and prognostic value of CD147 in endometrioid endometrial carcinoma (EEC) are limited. The present study analyzed the expression of CD147 and MMP‑2 by immunohistochemistry in endometrial tissue samples from 107 patients with EEC and 30 patients with benign uterus myoma. The association between CD147 and MMP‑2 expression and clinicopathological characteristics was evaluated. The results showed that the overexpression of MMP‑2 was significantly associated with International Federation of Gynecology and Obstetrics stage (P=0.007), depth of invasion (P=0.037) and reduced expression of progesterone receptor (P=0.005). Kaplan‑Meier analyses indicated that CD147 overexpression alone (P<0.05 for disease‑specific survival) or in combination with MMP‑2 (P<0.001 for disease‑specific survival) was correlated with adverse prognosis in EEC patients. Multivariate analysis revealed that the combined overexpression of CD147 and MMP‑2 was an independent prognostic factor for disease‑specific survival (hazard ratio=5.141, P=0.001) in EEC patients. CD147 and MMP‑2 overexpression was positively correlated with aggressive phenotypic features in EEC, however it was negatively correlated with hormone receptor expression. The combination of CD147 and MMP‑2 overexpression in EEC further distinguished a subgroup of patients with poor prognosis. Thus, the results of present study indicate that the co‑expression of CD147 and MMP‑2 may be an independent prognostic factor in EEC patients.
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July-2015
Volume 10 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yuan Y, Shen N, Yang SY, Zhao L and Guan YM: Extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 overexpression is associated with loss of hormone receptor expression and poor prognosis in endometrial cancer. Oncol Lett 10: 342-348, 2015.
APA
Yuan, Y., Shen, N., Yang, S., Zhao, L., & Guan, Y. (2015). Extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 overexpression is associated with loss of hormone receptor expression and poor prognosis in endometrial cancer. Oncology Letters, 10, 342-348. https://doi.org/10.3892/ol.2015.3177
MLA
Yuan, Y., Shen, N., Yang, S., Zhao, L., Guan, Y."Extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 overexpression is associated with loss of hormone receptor expression and poor prognosis in endometrial cancer". Oncology Letters 10.1 (2015): 342-348.
Chicago
Yuan, Y., Shen, N., Yang, S., Zhao, L., Guan, Y."Extracellular matrix metalloproteinase inducer and matrix metalloproteinase-2 overexpression is associated with loss of hormone receptor expression and poor prognosis in endometrial cancer". Oncology Letters 10, no. 1 (2015): 342-348. https://doi.org/10.3892/ol.2015.3177