Expression of the receptor for advanced glycation end‑products and frequency of polymorphism in lung cancer

Wang,Hongmei; Li,Yongchun; Yu,Wencheng; Ma,Liqing; Ji,Xia; Xiao,Wei

doi:10.3892/ol.2015.3200

Expression of the receptor for advanced glycation end‑products and frequency of polymorphism in lung cancer

Authors:
- Hongmei Wang
- Yongchun Li
- Wencheng Yu
- Liqing Ma
- Xia Ji
- Wei Xiao
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Affiliations: Department of Respiratory Medicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China, Asthma Laboratory, Qingdao Key Laboratory of Common Disease, Qingdao Municipal Hospital, Qingdao, Shandong 266071, P.R. China, Department of Respiratory Medicine, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China
Published online on: May 12, 2015 https://doi.org/10.3892/ol.2015.3200
Pages: 51-60
Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Receptor for advanced glycation end products (RAGE) is associated with the pathogenesis of cancer progression. The pathological effects mediated through RAGE are physiologically inhibited by soluble RAGE (sRAGE). The aim of the present study was to identify the expression of the sRAGE, RAGE and RAGE ligands in serum samples and lung cancer tissue obtained from lung cancer patients. Using ELISA and immunohistochemistry, it was observed that the sRAGE levels were downregulated in the serum, the expression of RAGE was decreased in the lung cancer tissue and the RAGE ligands HMGB1 and S100 were upregulated in cancer tissue. Furthermore, the presence of several selected types of RAGE polymorphism that occur in lung cancers were measured in the tissue samples. An association between the ‑429T/C and 2184A/G polymorphisms of RAGE and the genesis and progression of lung cancer was identified. The comparison between various histological subtypes and stages of lung cancer was performed with the aim to clarify the biological role of the RAGE gene, and identify a biomarker to aid diagnosis and predict the prognosis for lung cancer patients.

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