Trans‑bronchoscopy with implantation of 125I radioactive seeds in patients with pulmonary atelectasis induced by lung cancer

Lu,Mingjian; Pu,Deli; Zhang,Weidong; Liao,Jiangrong; Zhang,Tao; Yang,Guang; Liu,Zhenyin; Singh,Sristi; Gao,Fei; Zhang,Fujun

doi:10.3892/ol.2015.3204

Trans‑bronchoscopy with implantation of 125I radioactive seeds in patients with pulmonary atelectasis induced by lung cancer

Authors:
- Mingjian Lu
- Deli Pu
- Weidong Zhang
- Jiangrong Liao
- Tao Zhang
- Guang Yang
- Zhenyin Liu
- Sristi Singh
- Fei Gao
- Fujun Zhang
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Affiliations: Department of Medical Imaging & Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China, Department of Oncology, Guizhou Astronautics Hospital, Zunyi, Guizhou 563003, P.R. China
Published online on: May 13, 2015 https://doi.org/10.3892/ol.2015.3204
Pages: 216-222
Copyright: © Lu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

To evaluate the role of low‑dose‑rate interstitial brachytherapy using trans‑bronchoscope 125I radioactive seeds implantation in patients with pulmonary atelectasis induced by lung cancer, in terms of feasibility, safety, quality of life (QOL), and survival time. Between April 2008 and June 2011, 15 patients from two medical institutions that had obstructive pulmonary atelectasis caused by inoperable lung cancer were assigned to receive 125I implantation endoluminal brachytherapy by bronchoscopy. Subsequent to the implantation of 125I seeds, the outcomes were measured in terms of procedure success rate, reopening of atelectasis, complications associated with the procedure, Karnofsky performance status (KPS) scores and survival time. The surgical procedure was successfully performed in all 15 patients. No procedure‑associated mortality occurred and the complications were mild and considered acceptable. Irritable cough and temporary increase of hemoptysis occurred in 11 (73.3%) and 10 (66.7%) patients respectively, and were the most common complications. The pulmonary atelectasis reopening rate subsequent to the procedure was 86.7, 76.9, 80.0, 75.0 and 50.0% at 2, 6, 12, 18 and 24 months, respectively. The KPS score significantly improved following the implantation of 125I seeds and the duration of improvement ranged between 3 and 27 months. The median and mean survival times were 15.6 and 16 months, respectively. Actuarial survival rates at 6, 12 and 24 months after the procedure were 86.7, 66.7 and 13.3%, respectively. In patients with advanced lung cancer and those presenting with obstructive pulmonary atelectasis, treatment with intraluminal implantation of 125I seeds is a safe and effective therapy option with easy accessibility.

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