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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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July-2015 Volume 10 Issue 1

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Case Report Open Access

Complete resection of isolated hepatic metastatic uveal melanoma with a notably long disease-free period: A case report and review of the literature

  • Authors:
    • Shengzhang Lin
    • Dalong Wan
    • Haiyong Chen
    • Kangjie Chen
    • Shusen Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Hepato‑Biliary‑Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 196-200
    |
    Published online on: May 18, 2015
       https://doi.org/10.3892/ol.2015.3217
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Abstract

Although uveal melanoma frequently metastasizes to the liver, cases with a large solitary lesion with spontaneous intratumoral hemorrhage and necrosis are rarely encountered. Here, we report a case of metastatic hepatic melanoma that occurred in a 45‑year‑old Chinese male. The patient complained of the feeling of a full stomach for a month. Ten years earlier, the patient had undergone left ocular enucleation and artificial eye implantation at a different hospital. Postoperative pathology revealed choroidal melanoma without intrascleral or vascular involvement. Abdominal magnetic resonance imaging and computed tomography scan revealed a solitary lesion measuring 12 cm in diameter. A whole‑body F‑18‑fluoro‑2‑deoxyglucose (FDG) positron emission tomography/computed tomography scan demonstrated a large solitary nodule with increased FDG uptake. Computed tomography angiography revealed that the huge mass had partially ruptured and was bleeding spontaneously. For diagnostic and therapeutic purposes, right hepatectomy was performed and histological examination revealed that the tumor was metastatic melanoma.
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1 

Committee of Experts of the Chinese Society of Clinical Oncology for Melanoma, . China melanoma treatment guidelines (2011). Chin Clin Oncol. 159–171. 2012.

2 

Balch CM, Soong SJ, Gershenwald JE, et al: Prognostic factors analysis of 17,600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol. 19:3622–3634. 2001.PubMed/NCBI

3 

Kivelä T, Eskelin S, Mäkitie T and Summanen P: Exudative retinal detachment from malignant uveal melanoma: predictors and prognostic significance. Invest Ophthalmol Vis Sci. 42:2085–2093. 2001.PubMed/NCBI

4 

Yang XY, Xie F, Tao R, Li AJ and Wu MC: Treatment of liver metastases from uveal melanoma: a retrospective single-center analysis. Hepatobiliary Pancreat Dis Int. 12:602–606. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Rivoire M, Kodjikian L, Baldo S, Kaemmerlen P, Négrier S and Grange JD: Treatment of liver metastases from uveal melanoma. Ann Surg Oncol. 12:422–428. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Rietschel P, Panageas KS, Hanlon C, Patel A, Abramson DH and Chapman PB: Variates of survival in metastatic uveal melanoma. J Clin Oncol. 23:8076–8080. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Varghese S, Xu H, Bartlett D, et al: Isolated hepatic perfusion with high-dose melphalan results in immediate alterations in tumor gene expression in patients with metastatic ocular melanoma. Ann Surg Oncol. 17:1870–1877. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Peters S, Voelter V, Zografos L, et al: Intra-arterial hepatic fotemustine for the treatment of liver metastases from uveal melanoma: experience in 101 patients. Ann Oncol. 17:578–583. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Rubio S, Barbero-Villares A, Reina T, Nieto S, Mendoza J and García-Buey L: Rapidly-progressive liver failure secondary to melanoma infiltration. Gastroenterol Hepatol. 28:619–621. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Chun HJ, Osuga K, Fahrni M and Nakamura H: Massive bleeding of ruptured metastatic hepatic melanoma treated by transarterial embolization. Jpn J Radiol. 28:395–397. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Wagner WH, Lundell CJ and Donovan AJ: Percutaneous angiographic embolization for hepatic arterial hemorrhage. Arch Surg. 120:1241–1249. 1985. View Article : Google Scholar : PubMed/NCBI

12 

Cooperman AM, Weiland LH and Welch JS: Massive bleeding from a ruptured metastatic hepatic melanoma treated by hepatic lobectomy. Case report and review of the literature. Mayo Clin Proc. 51:167–170. 1976.PubMed/NCBI

13 

Papastefanou VP and Cohen VM: Uveal melanoma. J Skin Cancer. 2011:5739742011. View Article : Google Scholar : PubMed/NCBI

14 

Miyamoto C, Balazsi M, Bakalian S, Fernandes BF and Burnier MN Jr: Uveal melanoma: Ocular and systemic disease. Saudi J Ophthalmol. 26:145–149. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Materin MA, Faries M and Kluger HM: Molecular alternations in uveal melanoma. Curr Probl Cancer. 35:211–224. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Yang C and Wei W: The miRNA expression profile of the uveal melanoma. Sci China Life Sci. 54:351–358. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Sisley K, Doherty R and Cross NA: What hope for the future? GNAQ and uveal melanoma. Br J Ophthalmol. 95:620–623. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Rajpal S, Moore R and Karakousis CP: Survival in metastatic ocular melanoma. Cancer. 52:334–336. 1983. View Article : Google Scholar : PubMed/NCBI

19 

Crowley NJ and Seigler HF: Late recurrence of malignant melanoma. Analysis of 168 patients. Ann Surg. 212:173–177. 1990. View Article : Google Scholar : PubMed/NCBI

20 

Pons F, Plana M, Caminal JM, et al: Metastatic uveal melanoma: is there a role for conventional chemotherapy? - A single center study based on 58 patients. Melanoma Res. 21:217–222. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Hameed AM, Ng EE, Johnston E, et al: Hepatic resection for metastatic melanoma: a systematic review. Melanoma Res. 24:1–10. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Triozzi PL and Singh AD: Blood biomarkers of uveal melanoma metastasis. Br J Ophthalmol. 95:3–4. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Augsburger JJ, Corrêa ZM and Shaikh AH: Effectiveness of treatments for metastatic uveal melanoma. Am J Ophthalmol. 148:119–127. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Vahrmeijer AL, van de Velde CJ, Hartgrink HH and Tollenaar RA: Treatment of melanoma metastases confined to the liver and future perspectives. Dig Surg. 25:467–472. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Mariani P, Piperno-Neumann S, Servois V, et al: Surgical management of liver metastases from uveal melanoma: 16 years' experience at the Institut Curie. Eur J Surg Oncol. 35:1192–1197. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Aubin JM, Rekman J, Vandenbroucke-Menu F, et al: Systematic review and meta-analysis of liver resection for metastatic melanoma. Br J Surg. 100:1138–1147. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Zhao J, Yan LN and Li B: Adult-to-adult living donor liver transplantation for malignant metastatic melanoma to the liver. Hepatobiliary Pancreat Dis Int. 9:329–332. 2010.PubMed/NCBI

28 

You MX, Yu XX, Wu K, Lin YS, Zhu GQ and Shi CS: Analysis of risk factors for spontaneous rupture of hepatocellular carcinoma. Zhonghua Zhong Liu Za Zhi. 35:217–220. 2013.(In Chinese). PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lin S, Wan D, Chen H, Chen K and Zheng S: Complete resection of isolated hepatic metastatic uveal melanoma with a notably long disease-free period: A case report and review of the literature. Oncol Lett 10: 196-200, 2015.
APA
Lin, S., Wan, D., Chen, H., Chen, K., & Zheng, S. (2015). Complete resection of isolated hepatic metastatic uveal melanoma with a notably long disease-free period: A case report and review of the literature. Oncology Letters, 10, 196-200. https://doi.org/10.3892/ol.2015.3217
MLA
Lin, S., Wan, D., Chen, H., Chen, K., Zheng, S."Complete resection of isolated hepatic metastatic uveal melanoma with a notably long disease-free period: A case report and review of the literature". Oncology Letters 10.1 (2015): 196-200.
Chicago
Lin, S., Wan, D., Chen, H., Chen, K., Zheng, S."Complete resection of isolated hepatic metastatic uveal melanoma with a notably long disease-free period: A case report and review of the literature". Oncology Letters 10, no. 1 (2015): 196-200. https://doi.org/10.3892/ol.2015.3217
Copy and paste a formatted citation
x
Spandidos Publications style
Lin S, Wan D, Chen H, Chen K and Zheng S: Complete resection of isolated hepatic metastatic uveal melanoma with a notably long disease-free period: A case report and review of the literature. Oncol Lett 10: 196-200, 2015.
APA
Lin, S., Wan, D., Chen, H., Chen, K., & Zheng, S. (2015). Complete resection of isolated hepatic metastatic uveal melanoma with a notably long disease-free period: A case report and review of the literature. Oncology Letters, 10, 196-200. https://doi.org/10.3892/ol.2015.3217
MLA
Lin, S., Wan, D., Chen, H., Chen, K., Zheng, S."Complete resection of isolated hepatic metastatic uveal melanoma with a notably long disease-free period: A case report and review of the literature". Oncology Letters 10.1 (2015): 196-200.
Chicago
Lin, S., Wan, D., Chen, H., Chen, K., Zheng, S."Complete resection of isolated hepatic metastatic uveal melanoma with a notably long disease-free period: A case report and review of the literature". Oncology Letters 10, no. 1 (2015): 196-200. https://doi.org/10.3892/ol.2015.3217
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