Expression of the estrogen receptor α, progesterone receptor and epidermal growth factor receptor in papillary thyroid carcinoma tissues

Chen,Dan; Qi,Wenjing; Zhang,Pengxin; Guan,Hongwei; Wang,Lifen

doi:10.3892/ol.2015.3223

Expression of the estrogen receptor α, progesterone receptor and epidermal growth factor receptor in papillary thyroid carcinoma tissues

Authors:
- Dan Chen
- Wenjing Qi
- Pengxin Zhang
- Hongwei Guan
- Lifen Wang
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Affiliations: Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China, Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China
Published online on: May 19, 2015 https://doi.org/10.3892/ol.2015.3223
Pages: 317-320

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Abstract

The present study aimed to determine the protein expression, in addition to the clinical value of the expression, of estrogen receptor α (ERα), progesterone receptor (PR) and epidermal growth factor receptor (EGFR) in papillary thyroid carcinoma (PTC). The expression of ERα, PR and EGFR was examined immunohistochemically on paraffin‑embedded thyroid tissues obtained from 64 patients with PTC and 14 patients with nodular thyroid goiter (NTG). The expression level of ERα, PR and EGFR was found to be significantly elevated in the PTC tissues compared with the NTG tissues. In addition, the expression of ERα was found to be correlated with the size of PTC tumors. However, there was no significant difference between the expression levels of ERα, PR and EGFR in males and females with PTC. Thus, immunohistochemical evaluation of ERα, PR and EGFR expression in patients with PTC may aid in the prediction of the prognosis of patients with PTC.

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