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Efficacy of primary tumour volume as a predictor of survival compared with size alone in pancreatic ductal adenocarcinoma

  • Authors:
    • Justin S. Gundara
    • Anthony J. Gill
    • Jaswinder S. Samra
  • View Affiliations / Copyright

    Affiliations: Upper Gastrointestinal Surgical Unit, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW 2065, Australia, Department of Anatomical Pathology, Royal North Shore Hospital, University of Sydney, St. Leonards, NSW 2065, Australia
    Copyright: © Gundara et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 744-748
    |
    Published online on: May 22, 2015
       https://doi.org/10.3892/ol.2015.3254
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Abstract

Tumour size (TSize) predicts outcome in pancreatic ductal adenocarcinoma (PDAC), but little is known regarding three-dimensional tumour volume (TVol) associations. We hypothesised that TVol would more accurately predict outcome following pancreatoduodenectomy (PD) for PDAC. Clinicopathological and outcome data was reviewed for all PDs performed in the Royal North Shore Hospital (St. Leonards, NSW, Australia), between April 2004 and November 2010, in patients whose three tumour dimensions were recorded (n=103). TVol was quantified using the ellipsoidal volume formula, 4/3π(r1xr2xr3), and was correlated with clinicopathological indices/outcome. Over a median follow‑up time of 20.5 months, TVol failed to significantly predict post‑resection mortality [odds ratio (OR), 1.0; 95% confidence interval (CI), 0.99‑1.00; P=0.438)]. Neural invasion remained an overall independent predictor of mortality following multivariate analysis (OR, 3.94; 95% CI, 1.36‑11.40; P=0.011). Patients with higher TVol were more likely to require a vascular resection (P=0.007), had longer surgical times (P<0.001), larger intraoperative blood losses (P=0.007) and a trend toward worse survival (P=0.068). TVol inclusion in a multivariate model resulted in a small improvement in mortality prediction versus TSize (14.9 vs. 14.7%). A higher TVol results in a more complex perioperative course. Although TVol improved the mortality prediction beyond simple TSize alone, this difference was not significant. Studies normalising TVol for body composition are required.
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Copy and paste a formatted citation
Spandidos Publications style
Gundara JS, Gill AJ and Samra JS: Efficacy of primary tumour volume as a predictor of survival compared with size alone in pancreatic ductal adenocarcinoma. Oncol Lett 10: 744-748, 2015.
APA
Gundara, J.S., Gill, A.J., & Samra, J.S. (2015). Efficacy of primary tumour volume as a predictor of survival compared with size alone in pancreatic ductal adenocarcinoma. Oncology Letters, 10, 744-748. https://doi.org/10.3892/ol.2015.3254
MLA
Gundara, J. S., Gill, A. J., Samra, J. S."Efficacy of primary tumour volume as a predictor of survival compared with size alone in pancreatic ductal adenocarcinoma". Oncology Letters 10.2 (2015): 744-748.
Chicago
Gundara, J. S., Gill, A. J., Samra, J. S."Efficacy of primary tumour volume as a predictor of survival compared with size alone in pancreatic ductal adenocarcinoma". Oncology Letters 10, no. 2 (2015): 744-748. https://doi.org/10.3892/ol.2015.3254
Copy and paste a formatted citation
x
Spandidos Publications style
Gundara JS, Gill AJ and Samra JS: Efficacy of primary tumour volume as a predictor of survival compared with size alone in pancreatic ductal adenocarcinoma. Oncol Lett 10: 744-748, 2015.
APA
Gundara, J.S., Gill, A.J., & Samra, J.S. (2015). Efficacy of primary tumour volume as a predictor of survival compared with size alone in pancreatic ductal adenocarcinoma. Oncology Letters, 10, 744-748. https://doi.org/10.3892/ol.2015.3254
MLA
Gundara, J. S., Gill, A. J., Samra, J. S."Efficacy of primary tumour volume as a predictor of survival compared with size alone in pancreatic ductal adenocarcinoma". Oncology Letters 10.2 (2015): 744-748.
Chicago
Gundara, J. S., Gill, A. J., Samra, J. S."Efficacy of primary tumour volume as a predictor of survival compared with size alone in pancreatic ductal adenocarcinoma". Oncology Letters 10, no. 2 (2015): 744-748. https://doi.org/10.3892/ol.2015.3254
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