Article
Clinical analysis of 29 cases of nasal mucosal malignant melanoma
- Authors:
-
View Affiliations / Copyright
Affiliations:
Department of Otorhinolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital, Tianjin 300060, P.R. China
-
Pages:
1166-1170
|
Published online on:
May 25, 2015
https://doi.org/10.3892/ol.2015.3259
- Expand metrics +
Metrics:
Total
Views: 0
(Spandidos Publications: | PMC Statistics:
)
Metrics:
Total PDF Downloads: 0
(Spandidos Publications: | PMC Statistics:
)
This article is mentioned in:
Abstract
The present study aimed to investigate the clinical features of nasal mucosa malignant melanoma, including the histopathological features and factors affecting prognosis. A retrospective analysis of the clinical data obtained from the Department of Otolaryngology Head and Neck Surgery, Tianjin Huanhu Hospital (Tianjin, China) between October 1999 and June 2013 was performed using the Kaplan‑Meier method. In total, 29 cases of nasal mucosal malignant melanoma were analyzed. The overall 3‑ and 5‑year survival rates were 48.3 and 27.6%, respectively. The study group consisted of 18 males and 11 females, with a median age of 61.5 years. Overall, 19 patients underwent surgery, 28 received radiotherapy and 17 received chemotherapy. The American Joint Committee on Cancer staging system (AJCC) was used to retrospectively stage the tumors. In total, 8 were tumor stage (T)1, 10 were T2, 6 were T3 and 5 were T4. The results revealed that the T stage, surgical treatment, location of the tumor and the presence of black pigmentation affected the 5‑year survival rate of the patients. By contrast, radiotherapy and chemotherapy had no effect on the overall survival rate. Overall, endoscopic or endoscopic‑assisted surgery were the preferred methods of treatment, and histological features, including the presence of tumor melanin pigmentation, affected the prognosis of the patients. This study indicated that the AJCC staging system is able to effectively predict the prognosis of patients with nasal mucosa malignant melanoma.
View References
|
1
|
Manolidis S and Donald PJ: Malignant
mucosal melanoma of the head and neck: review of the literature and
report of 14 patients. Cancer. 80:1373–1386. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Prasad ML, Busam KJ, Patel SG,
Hoshaw-Woodard S, Shah JP and Huvos AG: Clinicopathologic
differences in malignant melanoma arising in oral squamous and
sinonasal respiratory mucosa of the upper aerodigestive tract. Arch
Pathol Lab Med. 127:997–1002. 2003.PubMed/NCBI
|
|
3
|
Greene FL, Page DL, Fleming ID, Fritz A,
Balch CM and Haller DG: AJCC Cancer Staging Manual. 6th.
Springer-Verlag; New York, NY: pp. 59–67. 2002
|
|
4
|
Dauer EH, Lewis JE, Rohlinger AL, Weaver
AL and Olsen KD: Sinonasal melanoma: a clinicopathologic review of
61 cases. Otolaryngol Head Neck Surg. 138:347–352. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Patel SG, Prasad ML, Escrig M, et al:
Primary mucosal malignant melanoma of the head and neck. Head Neck.
24:247–257. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Ballantyne AJ: Malignant melanoma of the
skin of the head and neck. An analysis of 405 cases. Am J Surg.
120:425–431. 1970. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Moreno MA, Roberts DB, Kupferman ME, et
al: Mucosal melanoma of the nose and paranasal sinuses, a
contemporary experience from the M. D. Anderson Cancer Center.
Cancer. 116:2215–2223. 2010.PubMed/NCBI
|
|
8
|
Bachar G, Loh KS, O'Sullivan B, et al:
Mucosal melanomas of the head and neck: experience of the Princess
Margaret Hospital. Head Neck. 30:1325–1331. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Penel N, Mallet Y, Mirabel X, Van JT and
Lefebvre JL: Primary mucosal melanoma of head and neck: prognostic
value of clear margins. Laryngoscope. 116:993–995. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Owens JM, Roberts DB and Myers JN: The
role of postoperative adjuvant radiation therapy in the treatment
of mucosal melanomas of the head and neck region. Arch Otolaryngol
Head Neck Surg. 129:864–868. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Temam S, Mamelle G, Marandas P, et al:
Postoperative radiotherapy for primary mucosal melanoma of the head
and neck. Cancer. 103:313–319. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Wada H, Nemoto K, Ogawa Y, et al: A
multi-institutional retrospective analysis of external radiotherapy
for mucosal melanoma of the head and neck in Northern Japan. Int J
Radiat Oncol Biol Phys. 59:495–500. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Krengli M, Masini L, Kaanders JH, et al:
Radiotherapy in the treatment of mucosal melanoma of the upper
aerodigestive tract: analysis of 74 cases. A Rare Cancer Network
study. Int J Radiat Oncol Biol Phys. 65:751–759. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
McLean N, Tighiouart M and Muller S:
Primary mucosal melanoma of the head and neck. Comparison of
clinical presentation and histopathologic features of oral and
sinonasal melanoma. Oral Oncol. 44:1039–1046. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Thompson LD, Wieneke JA and Miettinen M:
Sinonasal tract and nasopharyngeal melanomas: a clinicopathologic
study of 115 cases with a proposed staging system. Am J Surg
Pathol. 27:594–611. 2003. View Article : Google Scholar : PubMed/NCBI
|
