Pazopanib monotherapy in a patient with a malignant granular cell tumor originating from the right orbit: A case report

Morita,Sachi; Hiramatsu,Mariko; Sugishita,Mihoko; Gyawali,Bishal; Shibata,Takashi; Shimokata,Tomoya; Urakawa,Hiroshi; Mitsuma,Ayako; Moritani,Suzuko; Kubota,Toshinobu; Ichihara,Shu; Ando,Yuichi

doi:10.3892/ol.2015.3263

August-2015 Volume 10 Issue 2

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August-2015 Volume 10 Issue 2

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Case Report

Pazopanib monotherapy in a patient with a malignant granular cell tumor originating from the right orbit: A case report

Authors:
- Sachi Morita
- Mariko Hiramatsu
- Mihoko Sugishita
- Bishal Gyawali
- Takashi Shibata
- Tomoya Shimokata
- Hiroshi Urakawa
- Ayako Mitsuma
- Suzuko Moritani
- Toshinobu Kubota
- Shu Ichihara
- Yuichi Ando
View Affiliations / Copyright

Affiliations: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466‑8560, Japan, Department of Otorhinolaryngology, Nagoya Graduate School of Medicine, Nagoya, Aichi 466‑0027, Japan, Department of Pathology, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi 460‑0008, Japan, Department of Ophthalmology, National Hospital Organization Nagoya Medical Center, Nagoya, Aichi 460‑0008, Japan
Pages: 972-974
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Published online on: May 26, 2015

https://doi.org/10.3892/ol.2015.3263
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Abstract

Granular cell tumors are uncommon, usually benign tumors of Schwann cell origin. The malignant variant is extremely rare, representing <2% of all granular cell tumors. Therefore, standard systemic chemotherapy for this disease does not exist. The present study reports the case of a 40‑year‑old female with a malignant granular cell tumor that originally arose in the right orbit and subsequently relapsed. The patient was started on pazopanib monotherapy following treatment with two investigational drugs, a smoothened inhibitor and then a phosphatidylinositol 3‑kinase inhibitor, as part of a clinical trial. Although additional radiotherapy for local control was necessary, the lung metastases remained stable during the pazopanib monotherapy, which lasted for 7 months, following which a clinically stable disease state was determined. This case suggests that pazopanib can be a treatment option for the stabilization of disease progression in metastatic malignant granular cell tumor.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Pazopanib monotherapy in a patient with a malignant granular cell tumor originating from the right orbit: A case report

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