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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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August-2015 Volume 10 Issue 2

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Case Report

Eyelash trichomegaly following treatment with erlotinib in a non‑small cell lung cancer patient: A case report and literature review

  • Authors:
    • Shan‑Bing Wang
    • Kai‑Jian Lei
    • Jia‑Pei Liu
    • Yu‑Ming Jia
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Second People's Hospital of Yibin, Yibin, Sichuan 644000, P.R. China, Department of Laboratory Medicine, The Second People's Hospital of Yibin, Yibin, Sichuan 644000, P.R. China
  • Pages: 954-956
    |
    Published online on: May 26, 2015
       https://doi.org/10.3892/ol.2015.3265
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Abstract

Inhibitors of epidermal growth factor receptor (EGFR), including tyrosine kinase inhibitors (TKIs), present significant clinical benefits in the treatment of non‑small cell lung cancer (NSCLC), particularly in patients with an EGFR mutation. However, TKI treatment also results in unwanted cutaneous toxic side effects, such as a skin rash. Eyelash trichomegaly is rarely reported as a side effect; however, it causes cosmetic issues or eyeball irritation in patients, which may result in the early termination of TKI treatment. Therefore, although TKI‑induced eyelash trichomegaly is rare, it should be considered carefully by lung cancer physicians. The present study reported a case of erlotinib‑induced eyelash trichomegaly in a 65‑year‑old Chinese female patient suffering from NSCLC with an EGFR mutation. To the best of our knowledge, this is the first reported case of erlotinib‑induced trichomegaly in a Chinese patient.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al National Cancer Institute of Canada Clinical Trials Group: Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med. 353:123–132. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Mok TS, Wu YL, Thongprasert S, et al: Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med. 361:947–957. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Braiteh F, Kurzrock R and Johnson FM: Trichomegaly of the eyelashes after lung cancer treatment with the epidermal growth factor receptor inhibitor erlotinib. J Clin Oncol. 26:3460–3462. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Jeon SH, Ryu JS, Choi GS, et al: Erlotinib induced trichomegaly of the eyelashes. Tuberc Respir Dis (Seoul). 74:37–40. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Khozin S, Blumenthal GM, Jiang X, et al: U.S. Food and Drug Administration approval summary: Erlotinib for the first-line treatment of metastatic non-small cell lung cancer with epidermal growth factor receptor exon 19 deletions or exon 21 (L858R) substitution mutations. Oncologist. 19:774–779. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Gray H: Trichomegaly or movie lashes. Stanford Med Bull. 2:157–158. 1944.

8 

Oliver GL and McFarlane DC: Congenital trichomegaly: With associated pigmentary degeneration of the retina, dwarfism, and mental retardation. Arch Ophthalmol. 74:169–171. 1965. View Article : Google Scholar : PubMed/NCBI

9 

Kline AD, Krantz ID, Sommer A, et al: Cornelia de Lange syndrome: Clinical review, diagnostic and scoring systems and anticipatory guidance. Am J Med Genet A. 143A:1287–1296. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Ziakas NG, Jogiya A and Michaelides M: A case of familial trichomegaly in association with oculocutaneous albinism type 1. Eye (Lond). 18:863–864. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Cohen PR, Escudier SM and Kurzrock R: Cetuximab-associated elongation of the eyelashes: Case report and review of eyelash trichomegaly secondary to epidermal growth factor receptor inhibitors. Am J Clin Dermatol. 12:63–67. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Pascual JC, Bañuls J, Belinchon I, Blanes M and Massuti B: Trichomegaly following treatment with gefitinib (ZD1839). Br J Dermatol. 151:1111–1112. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Pucci N, Novembre E, Lombardi E, et al: Long eyelashes in a case series of 93 children with vernal keratoconjunctivitis. Pediatrics. 115:e86–e91. 2005.PubMed/NCBI

14 

Alpsoy E: Hypotrichosis, long eyelashes and atopic dermatitis: A new syndrome? J Eur Acad Dermatol Venereol. 18:374–375. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Carser JE and Summers YJ: Trichomegaly of the eyelashes after treatment with erlotinib in non-small cell lung cancer. J Thorac Oncol. 1:1040–1041. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Iacovelli R, Palazzo A, Trenta P, et al: Trichomegaly of the eyelashe induced by erlotinib therapy. Lung Cancer. 64 (Suppl 1):S59–2009. View Article : Google Scholar

17 

Lane K and Goldstein SM: Erlotinib-associated trichomegaly. Ophthal Plast Reconstr Surg. 23:65–66. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Vergou T, Stratigos AJ, Karapanagiotou EM, et al: Facial hypertrichosis and trichomegaly developing in patients treated with the epidermal growth factor receptor inhibitor erlotinib. J Am Acad Dermatol. 63:e56–e58. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Yarden Y and Sliwkowski MX: Untangling the ErbB signalling network. Nat Rev Mol Cell Biol. 2:127–137. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Hirsch FR and Bunn PA Jr: EGFR testing in lung cancer is ready for prime time. Lancet Oncol. 10:432–433. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Miller VA, Riely GJ, Zakowski MF, et al: Molecular characteristics of bronchioloalveolar carcinoma and adenocarcinoma, bronchioloalveolar carcinoma subtype, predict response to erlotinib. J Clin Oncol. 26:1472–1478. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Sequist LV, Martins RG, Spigel D, et al: First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol. 26:2442–2449. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Zhou C, Wu YL, Chen G, et al: Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study. Lancet Oncol. 12:735–742. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Petrelli F, Borgonovo K, Cabiddu M, Lonati V and Barni S: Relationship between skin rash and outcome in non-small-cell lung cancer patients treated with anti-EGFR tyrosine kinase inhibitors: A literature-based meta-analysis of 24 trials. Lung Cancer. 78:8–15. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Bouché O, Brixi-Benmansour H, Bertin A, Perceau G and Lagarde S: Trichomegaly of the eyelashes following treatment with cetuximab. Ann Oncol. 16:1711–1712. 2005. View Article : Google Scholar

26 

Shah NT, Kris MG, Pao W, et al: Practical management of patients with non-small-cell lung cancer treated with gefitinib. J Clin Oncol. 23:165–174. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang SB, Lei KJ, Liu JP and Jia YM: Eyelash trichomegaly following treatment with erlotinib in a non‑small cell lung cancer patient: A case report and literature review. Oncol Lett 10: 954-956, 2015.
APA
Wang, S., Lei, K., Liu, J., & Jia, Y. (2015). Eyelash trichomegaly following treatment with erlotinib in a non‑small cell lung cancer patient: A case report and literature review. Oncology Letters, 10, 954-956. https://doi.org/10.3892/ol.2015.3265
MLA
Wang, S., Lei, K., Liu, J., Jia, Y."Eyelash trichomegaly following treatment with erlotinib in a non‑small cell lung cancer patient: A case report and literature review". Oncology Letters 10.2 (2015): 954-956.
Chicago
Wang, S., Lei, K., Liu, J., Jia, Y."Eyelash trichomegaly following treatment with erlotinib in a non‑small cell lung cancer patient: A case report and literature review". Oncology Letters 10, no. 2 (2015): 954-956. https://doi.org/10.3892/ol.2015.3265
Copy and paste a formatted citation
x
Spandidos Publications style
Wang SB, Lei KJ, Liu JP and Jia YM: Eyelash trichomegaly following treatment with erlotinib in a non‑small cell lung cancer patient: A case report and literature review. Oncol Lett 10: 954-956, 2015.
APA
Wang, S., Lei, K., Liu, J., & Jia, Y. (2015). Eyelash trichomegaly following treatment with erlotinib in a non‑small cell lung cancer patient: A case report and literature review. Oncology Letters, 10, 954-956. https://doi.org/10.3892/ol.2015.3265
MLA
Wang, S., Lei, K., Liu, J., Jia, Y."Eyelash trichomegaly following treatment with erlotinib in a non‑small cell lung cancer patient: A case report and literature review". Oncology Letters 10.2 (2015): 954-956.
Chicago
Wang, S., Lei, K., Liu, J., Jia, Y."Eyelash trichomegaly following treatment with erlotinib in a non‑small cell lung cancer patient: A case report and literature review". Oncology Letters 10, no. 2 (2015): 954-956. https://doi.org/10.3892/ol.2015.3265
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