Case Report
Open Access
Pancreatic hemangioendothelioma, an extremely rare vascular anomaly in children: A case report and literature review
- Authors:
-
View Affiliations / Copyright
Affiliations:
Department of General Surgery, The Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zheijiang 310003, P.R. China
-
Pages:
793-797
|
Published online on:
May 26, 2015
https://doi.org/10.3892/ol.2015.3270
- Expand metrics +
Metrics:
Total
Views: 0
(Spandidos Publications: | PMC Statistics:
)
Metrics:
Total PDF Downloads: 0
(Spandidos Publications: | PMC Statistics:
)
This article is mentioned in:
Abstract
The current study presents the case of a female infant with pancreatic hemangioendothelioma (HE) and discusses this rare disease in terms of the clinical features, treatment principle and prognosis. An 8‑month‑old female with pancreatic HE was admitted to the Department of General Surgery in The Children's Hospital (Zhejiang University School of Medicine, Hangzhou, Zhejiang, China) on January 3, 2011, due to yellow skin and sclera that had been apparent for 1 week. Magnetic resonance imaging (MRI) showed dilatation in the left and right hepatic, common hepatic and common bile ducts, a pancreatic head mass of ~4.7x5.2 cm with a strong signal, and close linkage of the portal vein and mesenteric vessels to the mass. Laparotomy was performed on January 11, 2011. An intraoperative frozen specimen showed a benign tumor. Finally, Whipple surgery retaining the tumor was chosen. The patient was treated by fasting, gastrointestinal decompression, antibiotics and supportive treatment post‑surgery. Jaundice disappeared rapidly following the surgery. The patient started eating at 1 week post‑surgery and was discharged 1 week later. From the pathological results, a diagnosis of pancreatic HE was made, with no tumor invasion of the hepatic lymph nodes. During the follow‑up visit at 28 months post‑surgery, the child showed good growth and development. MRI showed that the mass size was ~2.4x2.0x1.5 cm, which was a significantly decrease from previously. Additionally, a literature search showed that from 1973 to the present date, only 9 studies on children with HE of the pancreas have been reported. Childhood pancreatic HE is a rare form of pancreatic vascular anomaly, mainly occurring in infants. If the tumor oppresses the duodenum and invades the mesenteric vessels, Whipple surgery retaining the tumor could be performed.
View Figures |
Figure 1
|
 |
Figure 2
|
 |
Figure 3
|
 |
Figure 4
|
 |
Figure 5
|
 |
Figure 6
|
View References
|
1
|
Sauer L, Harrison MR, Bond SJ, Flake AW,
Heyman MB and Ring EJ: Long-term percutaneous biliary drainage in
an infant with hemangioendothelioma. J Pediatr Surg. 22:606–608.
1987. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Vogel AM, Alesbury JM, Fox VL and Fishman
SJ: Complex pancreatic vascular anomalies in children. J Pediatr
Surg. 41:473–478. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Mulliken JB, Fishman SJ and Burrows PE:
Vascular anomalies. Curr Probl Surg. 37:517–584. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Lazure T, Tebboune N, Ben Lagha N, Triller
MF, Pariente D and Fabre M: Pancreatic vascular tumours of
childhood: A heterogeneous nosologic spectrum. Ann Pathol.
22:226–229. 2002.(In French). PubMed/NCBI
|
|
5
|
Villegas-Alvarez F and de Léon-Bojorge BY:
Hemangioendothelioma of the pancreas and choledochus, as a cause of
cholestatic neonatal and Kasabach-Merrit syndromes. Bol Med Hosp
Infant Mex. 46:672–675. 1989.(In Spanish). PubMed/NCBI
|
|
6
|
Villegas-Alvarez F and de Léon-Bojorge BY:
Hemangioendothelioma of the pancreas and choledochus, as a cause of
cholestatic neonatal and Kasabach-Merrit syndromes. Bol Med Hosp
Infant Mex. 46:672–675. 1989.(In Spanish). PubMed/NCBI
|
|
7
|
Chappell JS: Case reports. Benign
hemangioendothelioma of the head of the pancreas treated by
pancreaticoduodenectomy. J Pediatr Surg. 8:431–432. 1973.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Horie H, Iwasaki I, Iida H, Takizawa J,
Itoh F and Kohda S: Benign hemangioendothelioma of the pancreas
with obstructive jaundice. Acta Pathol Jpn. 35:975–979.
1985.PubMed/NCBI
|
|
9
|
Goldszmidt D, Pariente D, Yandza T,
Dubousset AM and Valayer J: Kasabach-Merritt syndrome with
pancreatic hemangioma in an infant. Arch Fr Pediatr. 50:593–597.
1993.(In French). PubMed/NCBI
|
|
10
|
Wang HP, Ge L and Yu SY: The treatment of
5 cases with pancreas tumors in children. Academic journal of
Shanghai Second Medical University. 24:691–692. 2004.(In
Chinese).
|
|
11
|
Park M, Koh KN, Kim BE, Im HJ, Kim DY and
Seo JJ: Pancreatic neoplasms in childhood and adolescence. J
Pediatr Hematol Oncol. 33:295–300. 2011. View Article : Google Scholar : PubMed/NCBI
|
