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Article

High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases

  • Authors:
    • Wei‑Ling Zhang
    • Yi Zhang
    • Tian Zhi
    • Dong‑Sheng Huang
    • Yi‑Zhuo Wang
    • Liang Hong
    • Xia Zhu
    • Ai‑Ping Liu
    • Hui‑Min Hu
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, P.R. China, Department of Pediatrics, Chinese PLA General Hospital, Beijing 100853, P.R. China
  • Pages: 1047-1053
    |
    Published online on: May 27, 2015
       https://doi.org/10.3892/ol.2015.3272
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Abstract

The aim of the present study was to assess the toxicity and efficacy of autologous peripheral blood stem cell (APBSC) transplantation in children with advanced malignant solid tumors. The outcomes of 38 children with advanced malignant solid tumor, who were treated with high‑dose chemotherapy and autologous peripheral blood stem cell transplantation in Beijing Tongren Hospital (Capital Medical University, Beijing, China) between September 2005 and November 2011, were retrospectively analyzed. The effects of treatment were evaluated according to the standard Bearman's criteria. The mean count of collected mononuclear cells and the cluster of differentiation 34+ cell count from 38 patients was 5.6±2.2x108/kg and 3.8±2.6x106/kg, respectively. From these 38 patients, the number of stem cells collected from 31 cases (81.6%) accorded with the transplantation standards. Three and 14 days after pretreatment in these 38 cases, there were 19 cases of grade I, 11 cases of grade Ⅱ, five cases of grade III and three cases of grade IV (one case succumbed) adverse reaction. Following the treatment (23‑40 days after pretreatment, during organ injury recovery), 37 cases obtained bone marrow reconstitution with a mean time of 12.3±3.1 days after APBSC reinfusion. The median survival time of the 37 patients was 49 months, and the survival rate at one, three and five years post‑treatment was 91.9, 68.2 and 36.6%, respectively.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang WL, Zhang Y, Zhi T, Huang DS, Wang YZ, Hong L, Zhu X, Liu AP and Hu HM: High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases. Oncol Lett 10: 1047-1053, 2015.
APA
Zhang, W., Zhang, Y., Zhi, T., Huang, D., Wang, Y., Hong, L. ... Hu, H. (2015). High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases. Oncology Letters, 10, 1047-1053. https://doi.org/10.3892/ol.2015.3272
MLA
Zhang, W., Zhang, Y., Zhi, T., Huang, D., Wang, Y., Hong, L., Zhu, X., Liu, A., Hu, H."High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases". Oncology Letters 10.2 (2015): 1047-1053.
Chicago
Zhang, W., Zhang, Y., Zhi, T., Huang, D., Wang, Y., Hong, L., Zhu, X., Liu, A., Hu, H."High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases". Oncology Letters 10, no. 2 (2015): 1047-1053. https://doi.org/10.3892/ol.2015.3272
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang WL, Zhang Y, Zhi T, Huang DS, Wang YZ, Hong L, Zhu X, Liu AP and Hu HM: High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases. Oncol Lett 10: 1047-1053, 2015.
APA
Zhang, W., Zhang, Y., Zhi, T., Huang, D., Wang, Y., Hong, L. ... Hu, H. (2015). High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases. Oncology Letters, 10, 1047-1053. https://doi.org/10.3892/ol.2015.3272
MLA
Zhang, W., Zhang, Y., Zhi, T., Huang, D., Wang, Y., Hong, L., Zhu, X., Liu, A., Hu, H."High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases". Oncology Letters 10.2 (2015): 1047-1053.
Chicago
Zhang, W., Zhang, Y., Zhi, T., Huang, D., Wang, Y., Hong, L., Zhu, X., Liu, A., Hu, H."High-dose chemotherapy combined with autologous peripheral blood stem cell transplantation in children with advanced malignant solid tumors: A retrospective analysis of 38 cases". Oncology Letters 10, no. 2 (2015): 1047-1053. https://doi.org/10.3892/ol.2015.3272
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