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Article

Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma

  • Authors:
    • Minfei Jin
    • Zujing Yang
    • Weiping Ye
    • Xiaowei Yu
    • Xiaolin Hua
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P.R. China, Department of Orthopedics, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 220023, P.R. China
  • Pages: 857-862
    |
    Published online on: June 4, 2015
       https://doi.org/10.3892/ol.2015.3319
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Abstract

Histone methyltransferase enhancer of zeste homolog 2 (EZH2) has been reported to be associated with certain malignant phenotypes in cervical cancer. However, clinicopathological parameters and clinical outcomes of EZH2 in cervical cancer, particularly in cervical squamous cell carcinoma (CSCC) remain largely unknown. The retrospective cohort comprising of 117 consecutive patients with CSCC was incorporated into a tissue microarray which also included 23 paired normal tissues. Immunohistochemical analysis was performed to evaluate the correlation between EZH2 expression and clinicopathological implications. Aberrant overexpression of EZH2 was frequently observed in CSCCs as compared with adjacent normal tissues (P=0.0005). Expression of EZH2 is associated with poor tumor differentiation grade (P=0.020) and lymphovascular invasion (P=0.012). Univariate analysis revealed that the patients with CSCC whose tumors exhibited higher EZH2 levels had inferior overall survival (OS) compared to those whose tumors expressed lower EZH2 (log rank P=0.004). In the multivariate analysis, EZH2 expression was an independent predictor of OS (hazard ratio = 1.836, 95% confidence interval: 1.090‑2.993, P=0.022). EZH2 overexpression is common in the development of CSCC and is a promising prognostic predictor for patients with CSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Jin M, Yang Z, Ye W, Yu X and Hua X: Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma. Oncol Lett 10: 857-862, 2015.
APA
Jin, M., Yang, Z., Ye, W., Yu, X., & Hua, X. (2015). Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma. Oncology Letters, 10, 857-862. https://doi.org/10.3892/ol.2015.3319
MLA
Jin, M., Yang, Z., Ye, W., Yu, X., Hua, X."Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma". Oncology Letters 10.2 (2015): 857-862.
Chicago
Jin, M., Yang, Z., Ye, W., Yu, X., Hua, X."Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma". Oncology Letters 10, no. 2 (2015): 857-862. https://doi.org/10.3892/ol.2015.3319
Copy and paste a formatted citation
x
Spandidos Publications style
Jin M, Yang Z, Ye W, Yu X and Hua X: Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma. Oncol Lett 10: 857-862, 2015.
APA
Jin, M., Yang, Z., Ye, W., Yu, X., & Hua, X. (2015). Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma. Oncology Letters, 10, 857-862. https://doi.org/10.3892/ol.2015.3319
MLA
Jin, M., Yang, Z., Ye, W., Yu, X., Hua, X."Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma". Oncology Letters 10.2 (2015): 857-862.
Chicago
Jin, M., Yang, Z., Ye, W., Yu, X., Hua, X."Prognostic significance of histone methyltransferase enhancer of zeste homolog 2 in patients with cervical squamous cell carcinoma". Oncology Letters 10, no. 2 (2015): 857-862. https://doi.org/10.3892/ol.2015.3319
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