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Article

DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells

Corrigendum in: /10.3892/ol.2023.13998
  • Authors:
    • Lv Lv
    • Jianyu Zhou
    • Changwei Lin
    • Gui Hu
    • Lu Yi
    • Juan Du
    • Kai Gao
    • Xiaorong Li
  • View Affiliations / Copyright

    Affiliations: Department of Emergency Medicine, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of General Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Neurosurgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China
  • Pages: 907-912
    |
    Published online on: June 8, 2015
       https://doi.org/10.3892/ol.2015.3336
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Abstract

The dysregulation of microRNA (miRNA) expression is highly involved in cancer. Recently, a number of studies have demonstrated that the silencing of specific miRNAs is associated with DNA methylation. The muscle‑specific miRNA‑113b (miR‑133b) is markedly downregulated in human colorectal cancer (CRC) compared with healthy colon cells, and is critical in the regulation of CRC cell proliferation and apoptosis. However, the mechanism of miR‑133b downregulation in CRC has yet to be elucidated. Therefore, the aim of the present study was to determine the existence of an association between DNA methylation and miR‑133b expression in CRC cells. It was identified that miR‑133b promoter hypermethylation is upregulated in CRC tissues. To investigate the role of miR‑133b methylation in CRC cells, the survival, cell cycle and invasion were analyzed in HT‑29 and SW620 CRC cells treated with 5‑aza‑2'‑deoxycytidine (5‑Aza‑CdR), 4‑phenylbutyric acid (PBA) and 5‑Aza‑CdR/PBA. Functional analysis demonstrated that demethylation increased the expression of miR‑133b, which restored migration and apoptosis in CRC cells. Thus, these results indicate that the regulation of miR‑133b methylation may provide a novel therapeutic strategy for CRC treatment.
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View References

1 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Sung JJ, Lau JY, Goh KL and Leung WKAsia Pacific Working Group on Colorectal Cancer: Increasing incidence of colorectal cancer in Asia: Implications for screening. Lancet Oncol. 6:871–876. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Calin GA and Croce CM: MicroRNA signatures in human cancers. Nat Rev Cancer. 6:857–866. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Lu J, Getz G, Miska EA, et al: MicroRNA expression profiles classify human cancers. Nature. 435:834–838. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Esquela-Kerscher A and Slack FJ: Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer. 6:259–269. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Manikandan J, Aarthi JJ, Kumar SD and Pushparaj PN: Oncomirs: The potential role of non-coding microRNAs in understanding cancer. Bioinformation. 2:330–334. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Meltzer PS: Cancer genomics: Small RNAs with big impacts. Nature. 435:745–746. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Fang K, Qian F and Chen YQ: MicroRNAs as regulators in normal hematopoietic and leukemia stem cells: Current concepts and clinical implications. Curr Mol Med. 12:536–546. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Saito Y, Liang G, Egger G, et al: Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell. 9:435–443. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Lujambio A, Ropero S, Ballestar E, et al: Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer Res. 67:1424–1429. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Suzuki H, Yamamoto E, Nojima M, et al: Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis. 31:2066–2073. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Toyota M, Suzuki H, Sasaki Y, et al: Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res. 68:4123–4132. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Koutsoulidou A, Mastroyiannopoulos NP, Furling D, Uney JB and Phylactou LA: Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle. BMC Dev Biol. 11:342011. View Article : Google Scholar : PubMed/NCBI

15 

Wu J, Yang T, Li X, et al: Alteration of serum miR-206 and miR-133b is associated with lung carcinogenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Toxicol Appl Pharmacol. 267:238–246. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Yamamoto H, Kohashi K, Fujita A and Oda Y: Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor. Mod Pathol. 26:563–571. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Zhao H, Li M, Li L, Yang X, Lan G and Zhang Y: MiR-133b is down-regulated in human osteosarcoma and inhibits osteosarcoma cells proliferation, migration and invasion and promotes apoptosis. PLoS One. 8:e835712013. View Article : Google Scholar : PubMed/NCBI

18 

Crawford M, Batte K, Yu L, et al: MicroRNA 133B targets pro-survival molecules MCL-1 and BCL2L2 in lung cancer. Biochem Biophys Res Commun. 388:483–489. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Patron JP, Fendler A, Bild M, et al: MiR-133b targets antiapoptotic genes and enhances death receptor-induced apoptosis. PLoS One. 7:e353452012. View Article : Google Scholar : PubMed/NCBI

20 

Hu G, Chen D, Li X, Yang K, Wang H and Wu W: miR-133b regulates the MET proto-oncogene and inhibits the growth of colorectal cancer cells in vitro and in vivo. Cancer Biol Ther. 10:190–197. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Xiang KM and Li XR: MiR-133b acts as a tumor suppressor and negatively regulates TBPL1 in colorectal cancer cells. Asian Pac J Cancer Prev. 15:3767–3772. 2014. View Article : Google Scholar : PubMed/NCBI

22 

General Assembly of the World Medical Association, . World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects. J Am Coll Dent. 81:14–18. 2014.PubMed/NCBI

23 

Izutsu N, Maesawa C, Shibazaki M, et al: Epigenetic modification is involved in aberrant expression of class III beta-tubulin, TUBB3, in ovarian cancer cells. Int J Oncol. 32:1227–1235. 2008.PubMed/NCBI

24 

Bandrés E, Cubedo E, Agirre X, et al: Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues. Mol Cancer. 5:292006. View Article : Google Scholar : PubMed/NCBI

25 

Ogasawara S, Maesawa C, Yamamoto M, et al: Disruption of cell-type-specific methylation at the Maspin gene promoter is frequently involved in undifferentiated thyroid cancers. Oncogene. 23:1117–1124. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Karpinski P, Szmida E, Misiak B, et al: Assessment of three epigenotypes in colorectal cancer by combined bisulfite restriction analysis. Mol Carcinog. 51:1003–1008. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Xiang T, Li L, Yin X, et al: The ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer. PLoS One. 7:e297832012. View Article : Google Scholar : PubMed/NCBI

28 

Saito Y, Friedman JM, Chihara Y, Egger G, Chuang JC and Liang G: Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells. Biochem Biophys Res Commun. 379:726–731. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Saito Y, Suzuki H, Tsugawa H, et al: Chromatin remodeling at Alu repeats by epigenetic treatment activates silenced microRNA-512-5p with downregulation of Mcl-1 in human gastric cancer cells. Oncogene. 28:2738–2744. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Duan FT, Qian F, Fang K, et al: miR-133b, a muscle-specific microRNA, is a novel prognostic marker that participates in the progression of human colorectal cancer via regulation of CXCR4 expression. Mol Cancer. 12:1642013. View Article : Google Scholar : PubMed/NCBI

31 

Wen D, Li S, Ji F, et al: miR-133b acts as a tumor suppressor and negatively regulates FGFR1 in gastric cancer. Tumour Biol. 34:793–803. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Zhou Y, Wu D, Tao J, Qu P, Zhou Z and Hou J: MicroRNA-133 inhibits cell proliferation, migration and invasion by targeting epidermal growth factor receptor and its downstream effector proteins in bladder cancer. Scand J Urol. 47:423–432. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Liu L, Shao X, Gao W, Zhang Z, Liu P, Wang R, Huang P, Yin Y and Shu Y: MicroRNA-133b inhibits the growth of non-small-cell lung cancer by targeting the epidermal growth factor receptor. FEBS J. 279:3800–3812. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Tao J, Wu D, Xu B, Qian W, Li P, Lu Q, Yin C and Zhang W: microRNA-133 inhibits cell proliferation, migration and invasion in prostate cancer cells by targeting the epidermal growth factor receptor. Oncol Rep. 27:1967–1975. 2012.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lv L, Zhou J, Lin C, Hu G, Yi L, Du J, Gao K and Li X: DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells Corrigendum in /10.3892/ol.2023.13998. Oncol Lett 10: 907-912, 2015.
APA
Lv, L., Zhou, J., Lin, C., Hu, G., Yi, L., Du, J. ... Li, X. (2015). DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells Corrigendum in /10.3892/ol.2023.13998. Oncology Letters, 10, 907-912. https://doi.org/10.3892/ol.2015.3336
MLA
Lv, L., Zhou, J., Lin, C., Hu, G., Yi, L., Du, J., Gao, K., Li, X."DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells Corrigendum in /10.3892/ol.2023.13998". Oncology Letters 10.2 (2015): 907-912.
Chicago
Lv, L., Zhou, J., Lin, C., Hu, G., Yi, L., Du, J., Gao, K., Li, X."DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells Corrigendum in /10.3892/ol.2023.13998". Oncology Letters 10, no. 2 (2015): 907-912. https://doi.org/10.3892/ol.2015.3336
Copy and paste a formatted citation
x
Spandidos Publications style
Lv L, Zhou J, Lin C, Hu G, Yi L, Du J, Gao K and Li X: DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells Corrigendum in /10.3892/ol.2023.13998. Oncol Lett 10: 907-912, 2015.
APA
Lv, L., Zhou, J., Lin, C., Hu, G., Yi, L., Du, J. ... Li, X. (2015). DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells Corrigendum in /10.3892/ol.2023.13998. Oncology Letters, 10, 907-912. https://doi.org/10.3892/ol.2015.3336
MLA
Lv, L., Zhou, J., Lin, C., Hu, G., Yi, L., Du, J., Gao, K., Li, X."DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells Corrigendum in /10.3892/ol.2023.13998". Oncology Letters 10.2 (2015): 907-912.
Chicago
Lv, L., Zhou, J., Lin, C., Hu, G., Yi, L., Du, J., Gao, K., Li, X."DNA methylation is involved in the aberrant expression of miR-133b in colorectal cancer cells Corrigendum in /10.3892/ol.2023.13998". Oncology Letters 10, no. 2 (2015): 907-912. https://doi.org/10.3892/ol.2015.3336
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