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The role of mechano-growth factor E peptide in the regulation of osteosarcoma

  • Authors:
    • Jin Shang
    • Xin Fan
    • Huan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China
    Copyright: © Shang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 697-704
    |
    Published online on: June 9, 2015
       https://doi.org/10.3892/ol.2015.3339
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Abstract

Osteosarcoma is one of the most common bone tumors, and exhibits a high degree of malignancy. Gene therapy is a novel approach to its treatment, however, specific target genes are required to enable effective use of this therapy. In order to investigate the effects of the mechano‑growth factor E (MGF‑E) peptide, which is derived from the IGF‑I alternative splicing isoform, on the regulation of the development of osteosarcoma, the expression of MGF was detected in osteosarcoma cell lines with different degrees of malignancy. Concomitantly, exogenous MGF‑E peptide was used to stimulate these osteosarcoma cell lines. The results demonstrated that MGF was overexpressed in malignant osteosarcoma cells, while it was not expressed in the least malignant osteosarcoma cells. Furthermore, MGF‑E treatment altered the cell cycle distribution, and promoted the proliferation, migration and invasion of osteosarcoma cells. The possible mechanisms underlying these effects were detected by quantitative polymerase chain reaction and western blotting. Based on these results, it was hypothesized that MGF may be a suitable biomarker for malignant osteosarcoma phenotypes.
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Copy and paste a formatted citation
Spandidos Publications style
Shang J, Fan X and Liu H: The role of mechano-growth factor E peptide in the regulation of osteosarcoma. Oncol Lett 10: 697-704, 2015.
APA
Shang, J., Fan, X., & Liu, H. (2015). The role of mechano-growth factor E peptide in the regulation of osteosarcoma. Oncology Letters, 10, 697-704. https://doi.org/10.3892/ol.2015.3339
MLA
Shang, J., Fan, X., Liu, H."The role of mechano-growth factor E peptide in the regulation of osteosarcoma". Oncology Letters 10.2 (2015): 697-704.
Chicago
Shang, J., Fan, X., Liu, H."The role of mechano-growth factor E peptide in the regulation of osteosarcoma". Oncology Letters 10, no. 2 (2015): 697-704. https://doi.org/10.3892/ol.2015.3339
Copy and paste a formatted citation
x
Spandidos Publications style
Shang J, Fan X and Liu H: The role of mechano-growth factor E peptide in the regulation of osteosarcoma. Oncol Lett 10: 697-704, 2015.
APA
Shang, J., Fan, X., & Liu, H. (2015). The role of mechano-growth factor E peptide in the regulation of osteosarcoma. Oncology Letters, 10, 697-704. https://doi.org/10.3892/ol.2015.3339
MLA
Shang, J., Fan, X., Liu, H."The role of mechano-growth factor E peptide in the regulation of osteosarcoma". Oncology Letters 10.2 (2015): 697-704.
Chicago
Shang, J., Fan, X., Liu, H."The role of mechano-growth factor E peptide in the regulation of osteosarcoma". Oncology Letters 10, no. 2 (2015): 697-704. https://doi.org/10.3892/ol.2015.3339
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