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Article

Evaluation of the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin regimen followed by radiotherapy or concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma

  • Authors:
    • Ting Jin
    • Xiao‑Zhong Chen
    • Jian‑Jiang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Radiation Oncology, Shaoxing People's Hospital, Shaoxing, Zhejiang 312000, P.R. China
  • Pages: 1123-1130
    |
    Published online on: June 10, 2015
       https://doi.org/10.3892/ol.2015.3349
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Abstract

The aim of the present study was to evaluate the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin chemotherapy regimen, followed by concurrent chemoradiotherapy or radiotherapy alone, in locoregionally advanced nasopharyngeal carcinoma (NPC). Eighty‑six patients with stage III, IVA or IVB NPC, who received neoadjuvant chemotherapy [gemcitabine, 1,000 mg/m2 on day 1 (d1) and d5; nedaplatin, 25 mg/m2 on d 1‑3] every 3 weeks for at least two cycles, followed by intensity‑modulated radiotherapy every 3 weeks, with or without concurrent nedaplatin (25 mg/m2, d1‑3) between September 2010 and December 2013, were retrospectively analyzed. By comparing pretreatment and post‑treatment MRI images, it was shown that seven patients achieved a complete response (8.5%), while 66 achieved a partial response (80.5%), following completion of neoadjuvant chemotherapy (combined response rate, 89.0%). Grade 3‑4 toxicities following neoadjuvant chemotherapy included neutropenia (29.1%), leukopenia (11.6%), liver dysfunction (9.3%), thrombocytopenia (9.3%) and nausea/vomiting (8.1%). The median follow‑up was 18 months (range, 5‑44 months). The 2‑year relapse‑free survival, distant metastasis‑free survival, progression‑free survival and overall survival rates were 96.6, 85.4, 83.3 and 96.1%, respectively. Compared with alternative neoadjuvant chemotherapy regimens in combination with radiotherapy or concurrent chemoradiotherapy, the present gemcitabine and nedaplatin did not provide additional survival benefit and led to a higher frequency of liver dysfunction. Therefore, neoadjuvant gemcitabine and nedaplatin should be used with caution in locoregionally advanced NPC.
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1 

Fandi A, Altun M, Azli N, Armand JP and Cvitkovic E: Nasopharyngeal cancer: Epidemiology, staging, and treatment. Semin Oncol. 21:382–397. 1994.PubMed/NCBI

2 

Henle G and Henle W: Epstein-Barr virus-specific IgA serum antibodies as an outstanding feature of nasopharyngeal carcinoma. Int J Cancer. 17:1–7. 1976. View Article : Google Scholar : PubMed/NCBI

3 

Pathmanathan R, Prasad U, Sadler R, Flynn K and Raab-Traub N: Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma. New Engl J Med. 333:693–698. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Hsu MM and Tu SM: Nasopharyngeal carcinoma in Taiwan. Clinical manifestations and results of therapy. Cancer. 52:362–368. 1983. View Article : Google Scholar : PubMed/NCBI

6 

Vokes EE, Liebowitz DN and Weichselbaum RR: Nasopharyngeal carcinoma. Lancet. 350:1087–1091. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Geara FB, Sanguineti G, Tucker SL, et al: Carcinoma of the nasopharynx treated by radiotherapy alone: Determinants of distant metastasis and survival. Radiother Oncol. 43:53–61. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Baujat B, Audry H, Bourhis J, et al: MAC-NPC Collaborative Group: Chemotherapy in locally advanced nasopharyngeal carcinoma: An individual patient data meta-analysis of eight randomized trials and 1753 patients. Int J Radiat Oncol Biol Phys. 64:47–56. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Lin JC, Jan JS, Hsu CY, et al: Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: Positive effect on overall and progression-free survival. J Clin Oncol. 21:631–637. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Chan AT, Teo PM, Ngan RK, et al: Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: Progression-free survival analysis of a phase III randomized trial. J Clin Oncol. 20:2038–2044. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Wee J, Tan EH, Tai BC, et al: Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapyin patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety. J Clin Oncol. 23:6730–6738. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Chen Y, Liu MZ, Liang SB, et al: Preliminary results of a prospective randomized trial comparing concurrent chemoradiotherapy plus adjuvant chemotherapy with radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma in endemic regions of China. Int J Radiat Oncol Biol Phys. 71:1356–1364. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Pfister DG, Ang KK, Brizel DM, et al: National Comprehensive Cancer Network Head and Neck Cancers, Version 2.2013 Featured updates on the NCCN guidelines. J Natl Compr Cancer Netw. 11:917–923. 2013.

14 

Al-Sarraf M, LeBlanc M, Giri PG, et al: Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized Intergroup study 0099. J Clin Oncol. 16:1310–1317. 1998.PubMed/NCBI

15 

Hui EP, Leung SF, Au JS, et al: Lung metastasis alone in nasopharyngeal carcinoma: A relatively favorable prognostic group. A study by the Hong Kong Nasopharyngeal Carcinoma Study Group. Cancer. 101:300–306. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Lee AW, Sze WM, Au JS, et al: Treatment results for nasopharyngeal carcinoma in the modern era: The Hong Kong experience. Int J Radiat Oncol. 61:1107–1116. 2005. View Article : Google Scholar

17 

Lee N, Xia P, Quivey JM, et al: Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: An update of the UCSF experience. Int J Radiat Oncol Biol Phys. 53:12–22. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Langendijk JA, Leemans CR, Buter J, Berkhof J and Slotman BJ: The additional value of chemotherapy to radiotherapy in locally advanced nasopharyngeal carcinoma: A meta-analysis of the published literature. J Clin Oncol. 22:4604–4612. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Chua DT, Ma J, Sham JS, et al: Long-term survival after cisplatin-based induction chemotherapy and radiotherapy for nasopharyngeal carcinoma: A pooled data analysis of two phase III trials. J Clin Oncol. 23:1118–1124. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Hui EP, Ma BB, Leung SF, et al: Randomized phase II trial of concurrent cisplatinradiotherapy with or without neoadjuvant docetaxel and cisplatin in advanced nasopharyngeal carcinoma. J Clin Oncol. 27:242–249. 2009. View Article : Google Scholar : PubMed/NCBI

21 

OuYang PY, Xie C, Mao YP, et al: Significant efficacies of neoadjuvant and adjuvant chemotherapy for nasopharyngeal carcinoma by meta-analysis of published literature-based randomized, controlled trials. Ann Oncol. 24:2136–2146. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Barton-Burke M: Gemcitabine: A pharmacologic and clinical overview. Cancer Nurs. 22:176–183. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Leong SS, Wee J, Tay MH, et al: Paclitaxel, carboplatin and gemcitabine in metastatic nasopharyngeal carcinoma: A phase II trial using a triplet combination. Cancer. 103:569–575. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Foo KF, Tan EH, Leong SS, et al: Gemcitabine in metastatic nasopharyngeal carcinoma of the undifferentiated type. Ann Oncol. 13:150–156. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Ngan RK, Yiu HH, Lau WH, et al: Combination gemcitabine and cisplatin chemotherapy for metastatic or recurrent nasopharyngeal carcinoma: Report of a phase II study. Ann Oncol. 13:1252–1258. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Wang CC, Chang JY, Liu TW, et al: Phase II study of gemcitabine plus vinorelbine in the treatment of cisplatin-resistant nasopharyngeal carcinoma. Head Neck. 28:74–80. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Kurita H, Yamamoto E, Nozaki S, et al: Multicenter phase I trial of induction chemotherapy with docetaxel and nedaplatin for oral squamous cell carcinoma. Oral Oncol. 40:1000–1006. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Zheng J, Wang G, Yang GY, et al: Induction chemotherapy with nedaplatin with 5-FU followed by intensity-modulated radiotherapy concurrent with chemotherapy for locoregionally advanced nasopharyngeal carcinoma. Jpn J Clin Oncol. 40:425–431. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Matsumoto M, Takeda Y, Maki H, et al: Preclinical in vivo antitumor efficacy of nedaplatin with gemcitabine against human lung cancer. Jpn J Cancer Res. 92:51–58. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Lim AM, Corry J, Collins M, et al: A phase II study of induction carboplatin and gemcitabine followed by chemoradiotherapy for the treatment of locally advanced nasopharyngeal carcinoma. Oral Oncol. 49:468–474. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Gu MF, Liu LZ, He LJ, et al: Sequential chemoradiotherapy with gemcitabine and cisplatin for locoregionally advanced nasopharyngeal carcinoma. Int J Cancer. 132:215–223. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Yau TK, Lee AW, Wong DH, et al: Induction chemotherapy with cisplatin and gemcitabine followed by accelerated radiotherapy and concurrentcisplatin in patients with stage IV (A-B) nasopharyngeal carcinoma. Head Neck. 28:880–887. 2006. View Article : Google Scholar : PubMed/NCBI

33 

He X, Ou D, Ying H, et al: Experience with combination of cisplatin plus gemcitabine chemotherapy and intensity-modulated radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Eur Arch Otorhinolaryngol. 269:1027–1033. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Han SH, Yu L, Zhang Z, et al: Evaluation of induction chemotherapy with vinorelbine plus cisplatin (NP) or docetaxel plus cisplatin (TP) combined with concurrent chemoradiotherapy for patients with locally advanced nasopharyngeal carcinoma. Zhonghua Zhong Liu Za Zhi. 35:623–626. 2013.(In Chinese). PubMed/NCBI

35 

Zhong YH, Dai J, Wang XY, et al: Phase II trial of neoadjuvant docetaxel and cisplatin followed by intensity-modulated radiotherapy with concurrent cisplatin in locally advanced nasopharyngeal carcinoma. Cancer Chemother Pharmacol. 71:1577–1583. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Ekenel M, Keskin S, Basaran M, et al: Induction chemotherapy with docetaxel and cisplatin is highly effective for locally advanced nasopharyngeal carcinoma. Oral Oncol. 47:660–664. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Du C, Ying H, Zhou J, Hu C and Zhang Y: Experience with combination of docetaxel, cisplatin plus 5-fluorouracil chemotherapy and intensity-modulated radiotherapy for locoregionally advanced nasopharyngeal carcinoma. Int J Clin Oncol. 18:464–471. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Kong L, Hu C, Niu X, et al: Neoadjuvant chemotherapy followed by concurrent chemoradiation for locoregionally advanced nasopharyngeal carcinoma: Interim results from 2 prospective phase 2 clinical trials. Cancer. 119:4111–4118. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Chen L, Mao YP, Xie FY, et al: The seventh edition of the UICC/AJCC staging system for nasopharyngeal carcinoma is prognostically useful for patients treated with intensity-modulated radiotherapy from an endemic area in China. Radiother Oncol. 104:331–337. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Schag CC, Heinrich RL and Ganz PA: Karnofsky performance status revisited: Reliability, validity, and guidelines. J Clin Oncol. 2:187–193. 1984.PubMed/NCBI

41 

Eisenhauer EA, Therasse P, Bogaerts J, et al: New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Liu YJ, Zhu GP and Guan XY: Comparison of the NCI-CTCAE version 4.0 and version 3.0 in assessing chemoradiation-induced oral mucositis for locally advanced nasopharyngeal carcinoma. Oral Oncol. 48:554–559. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Thompson L: World Health Organization classification of tumours: Pathology and genetics of head and neck tumours. Ear Nose Throat J. 85:742006.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jin T, Chen XZ and Liu JJ: Evaluation of the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin regimen followed by radiotherapy or concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma. Oncol Lett 10: 1123-1130, 2015.
APA
Jin, T., Chen, X., & Liu, J. (2015). Evaluation of the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin regimen followed by radiotherapy or concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma. Oncology Letters, 10, 1123-1130. https://doi.org/10.3892/ol.2015.3349
MLA
Jin, T., Chen, X., Liu, J."Evaluation of the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin regimen followed by radiotherapy or concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma". Oncology Letters 10.2 (2015): 1123-1130.
Chicago
Jin, T., Chen, X., Liu, J."Evaluation of the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin regimen followed by radiotherapy or concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma". Oncology Letters 10, no. 2 (2015): 1123-1130. https://doi.org/10.3892/ol.2015.3349
Copy and paste a formatted citation
x
Spandidos Publications style
Jin T, Chen XZ and Liu JJ: Evaluation of the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin regimen followed by radiotherapy or concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma. Oncol Lett 10: 1123-1130, 2015.
APA
Jin, T., Chen, X., & Liu, J. (2015). Evaluation of the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin regimen followed by radiotherapy or concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma. Oncology Letters, 10, 1123-1130. https://doi.org/10.3892/ol.2015.3349
MLA
Jin, T., Chen, X., Liu, J."Evaluation of the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin regimen followed by radiotherapy or concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma". Oncology Letters 10.2 (2015): 1123-1130.
Chicago
Jin, T., Chen, X., Liu, J."Evaluation of the efficacy and safety of a neoadjuvant gemcitabine and nedaplatin regimen followed by radiotherapy or concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma". Oncology Letters 10, no. 2 (2015): 1123-1130. https://doi.org/10.3892/ol.2015.3349
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