Suppression of MAL gene expression is associated with colorectal cancer metastasis

Ma,Rongqiang; Xu,Ye; Wang,Ming; Peng,Wei

doi:10.3892/ol.2015.3355

August-2015 Volume 10 Issue 2

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August-2015 Volume 10 Issue 2

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Article

Suppression of MAL gene expression is associated with colorectal cancer metastasis

Authors:
- Rongqiang Ma
- Ye Xu
- Ming Wang
- Wei Peng
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Affiliations: Department of Digestive Surgery, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, Xi'an, Shaanxi 710000, P.R. China, Department of Digestive Surgery, Shanghai Traditional Chinese Medicine‑Integrated Hospital, Shanghai 200082, P.R. China
Pages: 957-961
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Published online on: June 10, 2015

https://doi.org/10.3892/ol.2015.3355
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Abstract

Mal, T-cell differentiation protein (MAL) is a candidate tumor suppressor gene that functions in membrane trafficking processes in polarized epithelial cells. The aim of the present study was to determine its clinical significance in colorectal cancer (CRC). The RNA and protein expression levels of MAL in 30 colorectal specimens were detected by semi‑quantitative polymerase chain reaction and immunohistochemistry analysis. Statistical analysis was performed using SPSS software. The RNA level of MAL was significantly downregulated in the CRC tissues compared with the adjacent healthy tissue (P<0.05). MAL was only positively expressed in 20% of the CRC tissues, but in 66.7% of the adjacent tissues, as determined by immunohistochemistry analysis. The expression of the MAL RNA transcript exhibited a positive correlation with protein expression. The expression levels of MAL were significantly associated with different tumor‑node‑metastasis stages and lymph node metastasis (P<0.05), but not with age, gender, tumor site, differentiation status and pathological type (P>0.05). Suppression of MAL expression was significantly correlated with metastasis in CRC. The present study indicated that MAL may function as an anti-metastasis factor and represent a potential biomarker for malignant colorectal tumors.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Suppression of MAL gene expression is associated with colorectal cancer metastasis

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