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August-2015 Volume 10 Issue 2

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Review

BMI‑1, a promising therapeutic target for human cancer (Review)

  • Authors:
    • Min‑Cong Wang
    • Chun‑Li Li
    • Jie Cui
    • Min Jiao
    • Tao Wu
    • Li Jing
    • Ke‑Jun Nan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital, College of Medicine of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 583-588
    |
    Published online on: June 11, 2015
       https://doi.org/10.3892/ol.2015.3361
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Abstract

BMI‑1 oncogene is a member of the polycomb‑group gene family and a transcriptional repressor. Overexpression of BMI‑1 has been identified in various human cancer tissues and is known to be involved in cancer cell proliferation, cell invasion, distant metastasis, chemosensitivity and patient survival. Accumulating evidence has revealed that BMI‑1 is also involved in the regulation of self‑renewal, differentiation and tumor initiation of cancer stem cells (CSCs). However, the molecular mechanisms underlying these biological processes remain unclear. The present review summarized the function of BMI‑1 in different human cancer types and CSCs, and discussed the signaling pathways in which BMI‑1 is potentially involved. In conclusion, BMI‑1 may represent a promising target for the prevention and therapy of various cancer types.
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Copy and paste a formatted citation
Spandidos Publications style
Wang MC, Li CL, Cui J, Jiao M, Wu T, Jing L and Nan KJ: BMI‑1, a promising therapeutic target for human cancer (Review). Oncol Lett 10: 583-588, 2015.
APA
Wang, M., Li, C., Cui, J., Jiao, M., Wu, T., Jing, L., & Nan, K. (2015). BMI‑1, a promising therapeutic target for human cancer (Review). Oncology Letters, 10, 583-588. https://doi.org/10.3892/ol.2015.3361
MLA
Wang, M., Li, C., Cui, J., Jiao, M., Wu, T., Jing, L., Nan, K."BMI‑1, a promising therapeutic target for human cancer (Review)". Oncology Letters 10.2 (2015): 583-588.
Chicago
Wang, M., Li, C., Cui, J., Jiao, M., Wu, T., Jing, L., Nan, K."BMI‑1, a promising therapeutic target for human cancer (Review)". Oncology Letters 10, no. 2 (2015): 583-588. https://doi.org/10.3892/ol.2015.3361
Copy and paste a formatted citation
x
Spandidos Publications style
Wang MC, Li CL, Cui J, Jiao M, Wu T, Jing L and Nan KJ: BMI‑1, a promising therapeutic target for human cancer (Review). Oncol Lett 10: 583-588, 2015.
APA
Wang, M., Li, C., Cui, J., Jiao, M., Wu, T., Jing, L., & Nan, K. (2015). BMI‑1, a promising therapeutic target for human cancer (Review). Oncology Letters, 10, 583-588. https://doi.org/10.3892/ol.2015.3361
MLA
Wang, M., Li, C., Cui, J., Jiao, M., Wu, T., Jing, L., Nan, K."BMI‑1, a promising therapeutic target for human cancer (Review)". Oncology Letters 10.2 (2015): 583-588.
Chicago
Wang, M., Li, C., Cui, J., Jiao, M., Wu, T., Jing, L., Nan, K."BMI‑1, a promising therapeutic target for human cancer (Review)". Oncology Letters 10, no. 2 (2015): 583-588. https://doi.org/10.3892/ol.2015.3361
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