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Article

Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer

  • Authors:
    • Kento Kurata
    • Naoyoshi Onoda
    • Satoru Noda
    • Shinichiro Kashiwagi
    • Yuka Asano
    • Hidemi Kawajiri
    • Tsutomu Takashima
    • Sayaka Tanaka
    • Masahiko Ohsawa
    • Kosei Hirakawa
  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan, Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Osaka 545‑8585, Japan
  • Pages: 850-856
    |
    Published online on: June 11, 2015
       https://doi.org/10.3892/ol.2015.3366
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Abstract

The protein nestin, a neuronal stem cell marker, has been reported to indicate a poor prognosis in various tumours. Anaplastic thyroid cancer (ATC) is one of the most aggressive malignancies in humans, and its molecular background has not been identified. The present study evaluated the expression of nestin and its significance in ATC. Tissue samples from 23 patients with ATC were subjected to immunohistochemical staining and the staining intensity of nestin in the cytoplasm was evaluated. The expression of nestin in the tumour cytoplasm was confirmed in 6 of the 23 tissue samples (26.1%). Between the nestin‑positive group (n=6) and the nestin‑negative group (n=17), there were no significant differences in the clinicopathological factors of the patients. However, the nestin‑positive group exhibited significantly worse prognoses than the nestin‑negative group (median survival time, 86.5 vs. 306 days; P<0.01, log‑rank test). The multivariate analysis indicated that nestin expression was a prognostic indicator for the ATC patients (hazard ratio, 5.59; 95% confidence interval, 1.63‑19.50; P<0.01), which is independent of the known clinical indicators. Nestin expression has the potential to be an independent indicator of a poor prognosis for patients with ATC.
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Copy and paste a formatted citation
Spandidos Publications style
Kurata K, Onoda N, Noda S, Kashiwagi S, Asano Y, Kawajiri H, Takashima T, Tanaka S, Ohsawa M, Hirakawa K, Hirakawa K, et al: Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer. Oncol Lett 10: 850-856, 2015.
APA
Kurata, K., Onoda, N., Noda, S., Kashiwagi, S., Asano, Y., Kawajiri, H. ... Hirakawa, K. (2015). Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer. Oncology Letters, 10, 850-856. https://doi.org/10.3892/ol.2015.3366
MLA
Kurata, K., Onoda, N., Noda, S., Kashiwagi, S., Asano, Y., Kawajiri, H., Takashima, T., Tanaka, S., Ohsawa, M., Hirakawa, K."Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer". Oncology Letters 10.2 (2015): 850-856.
Chicago
Kurata, K., Onoda, N., Noda, S., Kashiwagi, S., Asano, Y., Kawajiri, H., Takashima, T., Tanaka, S., Ohsawa, M., Hirakawa, K."Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer". Oncology Letters 10, no. 2 (2015): 850-856. https://doi.org/10.3892/ol.2015.3366
Copy and paste a formatted citation
x
Spandidos Publications style
Kurata K, Onoda N, Noda S, Kashiwagi S, Asano Y, Kawajiri H, Takashima T, Tanaka S, Ohsawa M, Hirakawa K, Hirakawa K, et al: Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer. Oncol Lett 10: 850-856, 2015.
APA
Kurata, K., Onoda, N., Noda, S., Kashiwagi, S., Asano, Y., Kawajiri, H. ... Hirakawa, K. (2015). Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer. Oncology Letters, 10, 850-856. https://doi.org/10.3892/ol.2015.3366
MLA
Kurata, K., Onoda, N., Noda, S., Kashiwagi, S., Asano, Y., Kawajiri, H., Takashima, T., Tanaka, S., Ohsawa, M., Hirakawa, K."Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer". Oncology Letters 10.2 (2015): 850-856.
Chicago
Kurata, K., Onoda, N., Noda, S., Kashiwagi, S., Asano, Y., Kawajiri, H., Takashima, T., Tanaka, S., Ohsawa, M., Hirakawa, K."Nestin expression as an independent indicator of poor prognosis for patients with anaplastic thyroid cancer". Oncology Letters 10, no. 2 (2015): 850-856. https://doi.org/10.3892/ol.2015.3366
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