Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma (Review)

  • Authors:
    • Hiroshi Kobayashi
    • Hitomi Sugimoto
    • Shunsuke Onishi
    • Kazutoshi Nakano
  • View Affiliations

  • Published online on: June 11, 2015     https://doi.org/10.3892/ol.2015.3367
  • Pages: 612-618
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Abstract

Ovarian clear cell carcinoma can arise from endometriosis; however, it is distinct from other types of epithelial ovarian carcinoma in terms of its clinicopathological and molecular features. Cancer antigen 125 lacks the sensitivity and specificity required for accurate clinical diagnosis of clear cell carcinoma. Therefore, the aim of the current review was to identify novel biomarker candidates for the immunohistochemical and serological diagnosis of clear cell carcinoma. A search of the relevant English language literature published between 1966 and 2014 was conducted using the PubMed MEDLINE online database. High‑throughput tissue microarray technology and proteomic screening combined with mass spectrometry may provide additional information regarding diagnostic biomarker candidates for ovarian clear cell carcinoma. The present review summarizes the characteristics of potential genomic alterations that activate cancer signaling pathways and, thus, contribute to carcinogenesis. The major signaling pathways activated in clear cell carcinoma are associated with cell cycle regulation (hepatitis A virus cellular receptor 1 and tumor protein D52), growth factor signaling (insulin‑like growth factor binding protein 1; KiSS‑1 metastasis‑suppressor; erb‑b2 receptor tyrosine kinase 2; and fibroblast growth factor receptor 2), anti‑apoptosis and survival pathways [sialidase 3 (membrane sialidase)], metabolism (γ‑glutamyltransferase 1), chemoresistance (napsin A aspartic peptidase, glutathione peroxidase 3; and aldehyde dehydrogenase 1 family, member A1), coagulation [coagulation factor III (thromboplastin, tissue factor); and tissue factor pathway inhibitor 2], signaling (lectin, galactoside‑binding and soluble, 3), and adhesion and the extracellular matrix [cadherin 1, type 1, E‑cadherin (epithelial); versican; and laminin, α 5]. The present review of the relevant literature may provide a basis for additional clinical investigation of the ovarian clear cell carcinoma serum biomarker candidate proteins identified herein.
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August-2015
Volume 10 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Kobayashi H, Sugimoto H, Onishi S and Nakano K: Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma (Review). Oncol Lett 10: 612-618, 2015
APA
Kobayashi, H., Sugimoto, H., Onishi, S., & Nakano, K. (2015). Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma (Review). Oncology Letters, 10, 612-618. https://doi.org/10.3892/ol.2015.3367
MLA
Kobayashi, H., Sugimoto, H., Onishi, S., Nakano, K."Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma (Review)". Oncology Letters 10.2 (2015): 612-618.
Chicago
Kobayashi, H., Sugimoto, H., Onishi, S., Nakano, K."Novel biomarker candidates for the diagnosis of ovarian clear cell carcinoma (Review)". Oncology Letters 10, no. 2 (2015): 612-618. https://doi.org/10.3892/ol.2015.3367