Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients

  • Authors:
    • Jian‑Qiang Liu
    • Xia Bai
    • De‑Chen Duan
    • Ai‑Xia Dou
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Jinan No. 4 Hospital, Jinan, Shandong, P.R. China, Department of Hematology and Oncology, The Second Hospital of Shandong University, Jinan, Shandong, P.R. China
  • Pages: 1481-1486
    |
    Published online on: June 19, 2015
       https://doi.org/10.3892/ol.2015.3396
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study aimed to investigate the association between five common small nucleotide polymorphisms (SNPs) in the VEGF gene and the risk of osteosarcoma. An additional aim was to investigate the role of these five SNPs on the prognosis of osteosarcoma. A total of 186 patients with osteosarcoma and 186 age‑ and sex‑matched healthy controls were enrolled into the present study. A polymerase chain reaction‑restriction fragment length polymorphism assay was conducted to determine the incidence of the VEGF‑2578 C/A, ‑1156 G/A, +1612 G/A, +936 C/T and ‑634 G/C polymorphisms. Conditional logistic regression analyses revealed that individuals carrying the ‑634 GG genotype possessed a significantly increased risk of osteosarcoma, with an adjusted odds ratio [(95% confidence interval (CI)] of 2.00 (1.07‑3.75). In the Cox proportional hazards model, subsequent to adjusting for potential confounding factors, patients with osteosarcoma carrying the ‑634 GG genotype were found to demonstrate a shorter overall survival time (hazard ratio, 3.10; 95% CI, 1.17‑8.38). The VEGF‑634 G/C polymorphism may therefore be used as a genetic marker for the prediction of the risk and clinical outcome of osteosarcoma.
View Figures

Figure 1

View References

1 

Mirabello L, Troisi RJ and Savage SA: Osteosarcoma incidence and survival rates from 1973 to 2004: Data from the Surveillance, Epidemiology, and End Results Program. Cancer. 115:1531–1543. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Ottaviani G and Jaffe N: The epidemiology of osteosarcoma. Cancer Treat Res. 152:3–13. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Picci P: Osteosarcoma (osteogenic sarcoma). Orphanet J Rare Dis. 2:62007. View Article : Google Scholar : PubMed/NCBI

4 

Powers M, Zhang W, Lopez-Terrada D, Czerniak BA and Lazar AJ: The molecular pathology of sarcomas. Cancer Biomark. 9:475–491. 2010.PubMed/NCBI

5 

Bovée JV and Hogendoorn PC: Molecular pathology of sarcomas: Concepts and clinical implications. Virchows Arch. 456:193–199. 2010. View Article : Google Scholar : PubMed/NCBI

6 

de Álava E: Molecular pathology in sarcomas. Clin Transl Oncol. 9:130–144. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Osuna D and de Alava E: Molecular pathology of sarcomas. Rev Recent Clin Trials. 4:12–26. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Berger M, Muraro M, Fagioli F and Ferrari S: Osteosarcoma derived from donor stem cells carrying the Norrie's disease gene. N Engl J Med. 359:2502–2504. 2008. View Article : Google Scholar : PubMed/NCBI

9 

He M, Wang Z, Zhao J, Chen Y and Wu Y: COL1A1 polymorphism is associated with risks of osteosarcoma susceptibility and death. Tumour Biol. 35:1297–1305. 2014. View Article : Google Scholar : PubMed/NCBI

10 

He ML, Wu Y, Zhao JM, Wang Z and Chen YB: PIK3CA and AKT gene polymorphisms in susceptibility to osteosarcoma in a Chinese population. Asian Pac J Cancer Prev. 14:5117–5122. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Jia J, Tian Q, Liu Y, Shao ZW and Yang SH: Interactive effect of bisphenol A (BPA) exposure with −22G/C polymorphism in LOX gene on the risk of osteosarcoma. Asian Pac J Cancer Prev. 14:3805–3808. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Zhang SL, Mao NF, Sun JY, Shi ZC, Wang B and Sun YJ: Predictive potential of glutathione S-transferase polymorphisms for prognosis of osteosarcoma patients on chemotherapy. Asian Pac J Cancer Prev. 13:2705–2709. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Wang W, Wang J, Song H, Liu J, Song B and Cao X: Cytotoxic T-lymphocyte antigen-4 +49G/A polymorphism is associated with increased risk of osteosarcoma. Genet Test Mol Biomarkers. 15:503–506. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Patard JJ, Pouessel D, Bensalah K and Culine S: Targeted therapy in renal cell carcinoma. World J Urol. 26:135–140. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Rixe O, Oudard S, Negrier S, Szczylik C, Kim ST, et al: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 356:115–124. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Watson CJ, Webb NJ, Bottomley MJ and Brenchley PE: Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: Correlation with variation in VEGF protein production. Cytokine. 12:1232–1235. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Jain L, Vargo CA, Danesi R, Sissung TM, Price DK, Venzon D, Venitz J and Figg WD: The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors. Mol Cancer Ther. 8:2496–2508. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Yan Y, Liang H, Li T, Guo S, Li M, Li S and Qin X: Vascular endothelial growth factor +936C/T polymorphism and breast cancer risk: A meta-analysis of 13 case-control studies. Tumour Biol. 35:2687–2692. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Martinez-Fierro ML, Garza-Veloz I, Rojas-Martinez A, Ortiz-Lopez R, Castruita-de la Rosa C, Ortiz-Castro Y, Lazalde-Ramos BP, Cervantes-Villagrana AR, Castañeda-Lopez ME, Gomez-Guerra L, et al: Positive association between vascular endothelial growth factor (VEGF) −2578 C/A variant and prostate cancer. Cancer Biomark. 13:235–241. 2013.PubMed/NCBI

20 

Zhang Y, Li S, Xiao HQ, Hu ZX, Xu YC and Huang Q: Vascular endothelial growth factor gene polymorphisms and renal cell carcinoma: A systematic review and meta-analysis. Oncol Lett. 6:1068–1078. 2013.PubMed/NCBI

21 

Wang Z, Wen P, Luo X, Fang X, Wang Q, Ma F and Lv J: Association of the vascular endothelial growth factor (VEGF) gene single-nucleotide polymorphisms with osteosarcoma susceptibility in a Chinese population. Tumour Biol. 35:3605–3610. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Tie Z, Bai R, Zhai Z, Zhang G, Zhang H, Zhao Z, Zhou D and Liu W: Single nucleotide polymorphisms in VEGF gene are associated with an increased risk of osteosarcoma. Int J Clin Exp Pathol. 7:8143–8149. 2014.PubMed/NCBI

23 

Enneking WF, Spanier SS and Goodman MA: A system for the surgical staging of musculoskeletal sarcoma. Clin Orthop Relat Res. 106–120. 1980.PubMed/NCBI

24 

Salven P, Teerenhovi L and Joensuu H: A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin's lymphoma. Blood. 90:3167–3172. 1997.PubMed/NCBI

25 

Leng WD, He MN, Chen QL, Gong H, Zhang L and Zeng XT: Vascular endothelial growth factor (VEGF) gene polymorphisms and risk of head and neck cancer: A meta-analysis involving 2,444 individuals. Mol Biol Rep. 40:5987–5992. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Kushner EJ and Bautch VL: Building blood vessels in development and disease. Curr Opin Hematol. 20:231–236. 2013.PubMed/NCBI

27 

Roy H, Bhardwaj S and Ylä-Herttuala S: Biology of vascular endothelial growth factors. FEBS Lett. 580:2879–2887. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Renner W, Kotschan S, Hoffmann C, Obermayer-Pietsch B and Pilger E: A common 936 C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels. J Vasc Res. 37:443–448. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Koukourakis MI, Papazoglou D, Giatromanolaki A, Bougioukas G, Maltezos E and Sivridis E: VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. Lung Cancer. 46:293–298. 2004. View Article : Google Scholar : PubMed/NCBI

30 

Liu H, Wang S and Huang C: VEGFA+936C/T and −634G/C polymorphisms and gastric cancer risk: A meta-analysis. Asian Pac J Cancer Prev. 12:1979–1983. 2011.PubMed/NCBI

31 

Zhao Z, Ba C, Wang W, Wang X, Xue R and Wu X: Vascular endothelial growth factor (VEGF) gene polymorphisms and colorectal cancer: A meta-analysis of epidemiologic studies. Genet Test Mol Biomarkers. 16:1390–1394. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Deng ZC, Cao C, Yu YM, Ma HY and Ye M: Vascular endothelial growth factor −634G/C and vascular endothelial growth factor −2578C/A polymorphisms and lung cancer risk: A case-control study and meta-analysis. Tumour Biol. 35:1805–1811. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Yao W, Yan R, Ma L, Wan H, Yu Y, Cheng X and Li Y: Vascular endothelial growth factor gene polymorphism (−634G/C) and breast cancer risk. Tumour Biol. 35:7793–7798. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Sa-Nguanraksa D, Chuangsuwanich T, Pongpruttipan T, Kummalue T, Rojananin S, Ratanawichhitrasin A, Prasarttong-Osoth P, Chuthatisith S, Pisarnturakit P, Aeumrithaicharoenchok W, et al: Vascular endothelial growth factor 634G/C polymorphism is associated with increased breast cancer risk and aggressiveness. Mol Med Rep. 8:1242–1250. 2013.PubMed/NCBI

35 

Liao WC, Lin JT, Wu CY, Huang SP, Lin MT, Wu AS, Huang YJ and Wu MS: Serum interleukin-6 level but not genotype predicts survival after resection in stages II and III gastric carcinoma. Clin Cancer Res. 14:428–434. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Sfar S, Saad H, Mosbah F and Chouchane L: Combined effects of the angiogenic genes polymorphisms on prostate cancer susceptibility and aggressiveness. Mol Biol Rep. 36:37–45. 2009. View Article : Google Scholar : PubMed/NCBI

37 

Hefler LA, Mustea A, Könsgen D, Concin N, et al: Vascular endothelial growth factor gene polymorphisms are associated with prognosis in ovarian cancer. Clin Cancer Res. 13:898–901. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu JQ, Bai X, Duan DC and Dou AX: Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients. Oncol Lett 10: 1481-1486, 2015.
APA
Liu, J., Bai, X., Duan, D., & Dou, A. (2015). Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients. Oncology Letters, 10, 1481-1486. https://doi.org/10.3892/ol.2015.3396
MLA
Liu, J., Bai, X., Duan, D., Dou, A."Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients". Oncology Letters 10.3 (2015): 1481-1486.
Chicago
Liu, J., Bai, X., Duan, D., Dou, A."Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients". Oncology Letters 10, no. 3 (2015): 1481-1486. https://doi.org/10.3892/ol.2015.3396
Copy and paste a formatted citation
x
Spandidos Publications style
Liu JQ, Bai X, Duan DC and Dou AX: Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients. Oncol Lett 10: 1481-1486, 2015.
APA
Liu, J., Bai, X., Duan, D., & Dou, A. (2015). Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients. Oncology Letters, 10, 1481-1486. https://doi.org/10.3892/ol.2015.3396
MLA
Liu, J., Bai, X., Duan, D., Dou, A."Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients". Oncology Letters 10.3 (2015): 1481-1486.
Chicago
Liu, J., Bai, X., Duan, D., Dou, A."Role of five small nucleotide polymorphisms in the VEGF gene on the susceptibility to osteosarcoma and overall survival of patients". Oncology Letters 10, no. 3 (2015): 1481-1486. https://doi.org/10.3892/ol.2015.3396
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team