Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells

  • Authors:
    • Tomohiko Obayashi
    • Kohei Funasaka
    • Eizaburo Ohno
    • Ryoji Miyahara
    • Yoshiki Hirooka
    • Michinari Hamaguchi
    • Hidemi Goto
    • Takeshi Senga
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Division of Cancer Biology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan
  • Pages: 1836-1840
    |
    Published online on: June 19, 2015
       https://doi.org/10.3892/ol.2015.3399
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cancer remains one of the leading causes of human mortality worldwide. Radiation and chemotherapy are commonly used for cancer treatment; however, the combination of these therapies and surgery do not completely eradicate cancer cells. Near‑infrared radiation (NIR) is a low‑energy form of radiation that exerts multiple effects on mammalian cells. Previous studies have reported that NIR induces DNA double‑strand breaks and apoptosis of cancer cells. In the present study, a 915‑nm laser was used to examine the effects of NIR on pancreatic cancer cells. Irradiation of pancreatic cancer cells using a 915‑nm laser significantly induced caspase‑3 activation and apoptosis. In addition, the combination of gemcitabine treatment and a 915‑nm laser synergistically increased the number of apoptotic cells. The results of the present study indicate the use of infrared irradiation and chemotherapy may be a possible therapy for the treatment of cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Chabner BA and Roberts TG Jr: Timeline: Chemotherapy and the war on cancer. Nat Rev Cancer. 5:65–72. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Salama JK, Chmura SJ, Mehta N, Yenice KM, Stadler WM, Vokes EE, Haraf DJ, Hellman S and Weichselbaum RR: An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease. Clin Cancer Res. 14:5255–5259. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Davis AJ and Chen DJ: DNA double strand break repair via non-homologous end-joining. Transl Cancer Res. 2:130–143. 2013.PubMed/NCBI

4 

Grossman N, Schneid N, Reuveni H, Halevy S and Lubart R: 780 nm low power diode laser irradiation stimulates proliferation of keratinocyte cultures: Involvement of reactive oxygen species. Lasers Surg Med. 22:212–218. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Karu T and Pyatibrat L: Gene expression under laser and light-emitting diodes radiation for modulation of cell adhesion: Possible applications for biotechnology. IUBMB Life. 63:747–753. 2011.PubMed/NCBI

6 

Oron U, Yaakobi T, Oron A, Mordechovitz D, Shofti R, Hayam G, Dror U, Gepstein L, Wolf T, Haudenschild C and Haim SB: Low-energy laser irradiation reduces formation of scar tissue after myocardial infarction in rats and dogs. Circulation. 103:296–301. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Oron U, Yaakobi T, Oron A, Hayam G, Gepstein L, Rubin O, Wolf T and Ben Haim S: Attenuation of infarct size in rats and dogs after myocardial infarction by low-energy laser irradiation. Lasers Surg Med. 28:204–211. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Shefer G, Barash I, Oron U and Halevy O: Low-energy laser irradiation enhances de novo protein synthesis via its effects on translation-regulatory proteins in skeletal muscle myoblasts. Biochim Biophys Acta. 1593:131–139. 2003. View Article : Google Scholar : PubMed/NCBI

9 

Santana-Blank LA, Rodríguez-Santana E, Vargas F, Reyes H, Fernández-Andrade P, Rukos S and Santana-Rodríguez KE: Phase I trial of an infrared pulsed laser device in patients with advanced neoplasias. Clin Cancer Res. 8:3082–3091. 2002.PubMed/NCBI

10 

Tanaka Y, Matsuo K, Yuzuriha S, Yan H and Nakayama J: Non-thermal cytocidal effect of infrared irradiation on cultured cancer cells using specialized device. Cancer Sci. 101:1396–1402. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Shalini S, Dorstyn L, Dawar S and Kumar S: Old, new and emerging functions of caspases. Cell Death Differ. 22:526–539. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Tanaka Y, Matsuo K and Yuzuriha S: Near-infrared irradiation non-thermally affects subcutaneous adipocytes and bones. Eplasty. 11:e122011.PubMed/NCBI

13 

Tanaka Y, Matsuo K and Yuzuriha S: Near-infrared irradiation nonthermally induces long-lasting vasodilation by causing apoptosis of vascular smooth muscle cells. Eplasty. 11:e222011.PubMed/NCBI

14 

Schroeder P, Pohl C, Calles C, Marks C, Wild S and Krutmann J: Cellular response to infrared radiation involves retrograde mitochondrial signaling. Free Radic Biol Med. 43:128–135. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Karu TI: Mitochondrial signaling in mammalian cells activated by red and near-IR radiation. Photochem Photobiol. 84:1091–1099. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Karu TI: Multiple roles of cytochrome c oxidase in mammalian cells under action of red and IR-A radiation. IUBMB Life. 62:607–610. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Karu T: Primary and secondary mechanisms of action of visible to near-IR radiation on cells. J Photochem Photobiol B. 49:1–17. 1999. View Article : Google Scholar : PubMed/NCBI

18 

Karu TI, Pyatibrat LV, Kolyakov SF and Afanasyeva NI: Absorption measurements of a cell monolayer relevant to phototherapy: Reduction of cytochrome c oxidase under near IR radiation. J Photochem Photobiol B. 81:98–106. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Anders JJ, Romanczyk TB, Ilev IK, Moges H, Longo L, Wu X and Waynant RW: Light supports neurite outgrowth of human neural progenitor cells in vitro: The role of P2Y receptors. IEEE J- Sel Top Quantum Electron. 14:118–125. 2008. View Article : Google Scholar

20 

Karu T, Pyatibrat L and Kalendo G: Irradiation with He-Ne laser can influence the cytotoxic response of HeLa cells to ionizing radiation. Int J Radiat Biol. 65:691–697. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Dees C, Harkins J, Petersen MG, Fisher WG and Wachter EA: Treatment of murine cutaneous melanoma with near infrared light. Photochem Photobiol. 75:296–301. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Tirlapur UK and König K: Femtosecond near-infrared laser pulse induced strand breaks in mammalian cells. Cell Mol Biol (Noisy-le-grand). 47:OL131–OL134. 2001.PubMed/NCBI

23 

Tanaka Y, Tatewaki N, Nishida H, Eitsuka T, Ikekawa N and Nakayama J: Non-thermal DNA damage of cancer cells using near-infrared irradiation. Cancer Sci. 103:1467–1473. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Hidalgo M: Pancreatic cancer. N Engl J Med. 362:1605–1617. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Berlin J and Benson AB III: Chemotherapy: Gemcitabine remains the standard of care for pancreatic cancer. Nat Rev Clin Oncol. 7:135–137. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Obayashi T, Funasaka K, Ohno E, Miyahara R, Hirooka Y, Hamaguchi M, Goto H and Senga T: Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells. Oncol Lett 10: 1836-1840, 2015.
APA
Obayashi, T., Funasaka, K., Ohno, E., Miyahara, R., Hirooka, Y., Hamaguchi, M. ... Senga, T. (2015). Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells. Oncology Letters, 10, 1836-1840. https://doi.org/10.3892/ol.2015.3399
MLA
Obayashi, T., Funasaka, K., Ohno, E., Miyahara, R., Hirooka, Y., Hamaguchi, M., Goto, H., Senga, T."Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells". Oncology Letters 10.3 (2015): 1836-1840.
Chicago
Obayashi, T., Funasaka, K., Ohno, E., Miyahara, R., Hirooka, Y., Hamaguchi, M., Goto, H., Senga, T."Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells". Oncology Letters 10, no. 3 (2015): 1836-1840. https://doi.org/10.3892/ol.2015.3399
Copy and paste a formatted citation
x
Spandidos Publications style
Obayashi T, Funasaka K, Ohno E, Miyahara R, Hirooka Y, Hamaguchi M, Goto H and Senga T: Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells. Oncol Lett 10: 1836-1840, 2015.
APA
Obayashi, T., Funasaka, K., Ohno, E., Miyahara, R., Hirooka, Y., Hamaguchi, M. ... Senga, T. (2015). Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells. Oncology Letters, 10, 1836-1840. https://doi.org/10.3892/ol.2015.3399
MLA
Obayashi, T., Funasaka, K., Ohno, E., Miyahara, R., Hirooka, Y., Hamaguchi, M., Goto, H., Senga, T."Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells". Oncology Letters 10.3 (2015): 1836-1840.
Chicago
Obayashi, T., Funasaka, K., Ohno, E., Miyahara, R., Hirooka, Y., Hamaguchi, M., Goto, H., Senga, T."Treatment with near-infrared radiation promotes apoptosis in pancreatic cancer cells". Oncology Letters 10, no. 3 (2015): 1836-1840. https://doi.org/10.3892/ol.2015.3399
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team