Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2015 Volume 10 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Expression of TYMS in lymph node metastasis from low‑grade glioma

  • Authors:
    • Bingqian Ding
    • Ming Gao
    • Zhenjiang Li
    • Chenyang Xu
    • Shaokang Fan
    • Weiya He
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, P.R. China, Department of Neurology, Huaihe Hospital of Henan University, Kaifeng, Henan 475000, P.R. China
  • Pages: 1569-1574
    |
    Published online on: June 24, 2015
       https://doi.org/10.3892/ol.2015.3419
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the expression of thymidylate synthase (TYMS) in the primary foci and metastatic lymph nodes of low‑grade glioma, and to analyze the function of TYMS in the lymph node metastases from low‑grade glioma. The study included 93 cases of surgically resected and pathologically confirmed low‑grade glioma, form patients treated at Huaihe Hospital of Henan University (Kaifeng, China). The following clinical data was obtained from each patient: Gender, age, subjective symptoms (dizziness, headache, a feeling of pressure in the head, etc.), site of disease, tumor type, pathological stage, degree of differentiation and lymph node involvement. The surgically resected gliomas and dissected cervical lymph nodes were immunohistochemically stained, and DNA was extracted from the tumor and lymph node tissues samples for polymerase chain reaction sequencing and amplification. The expression of TYMS in the primary foci and metastatic lymph nodes of low‑grade glioma was examined. Additionally, the association between pathological features and the postoperative survival rate of the patients was analyzed. The primary lesions of all 93 cases exhibited positive TYMS expression and 43/157 (27.39%) lymph nodes exhibited positive TYMS expression. Factors that significantly influenced the postoperative survival rate of the patients, included the metastasis of the cervical lymph nodes (P<0.01), the number of dissected cervical lymph nodes (P<0.01) and the degree of differentiation (P<0.05). The metastasis of the cervical lymph nodes was the only independent risk factor affecting postoperative disease‑free survival. The risk of recurrence in patients with metastasis of the cervical lymph nodes was 6.3‑fold higher than in those without metastasis (P<0.01). Thus, the results of the present study provide a theoretical basis for accurately predicting the prognosis of patients with low‑grade malignant brain glioma, reducing the conjecture involved in selecting postoperative treatment strategies and improving therapeutic efficacy.
View Figures

Figure 1

View References

1 

Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, et al: Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 10:459–466. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Sanai N, Chang S and Berger MS: Low-grade gliomas in adults. J Neurosurg. 115:948–965. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Stewart LA: Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet. 359:1011–1018. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Athanassiou H, Synodinou M, Maragoudakis E, Paraskevaidis M, Verigos C, Misailidou D, Antonadou D, Saris G, Beroukas K and Karageorgis P: Randomised phase II study of temozolomide and radiotherapy compared with radiotherapy alone in newly diagnosed glioblastoma multiforme. J Clin Oncol. 23:2372–2377. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Mason WP, Maestro RD, Eisenstat D, Forsyth P, Fulton D, Laperrière N, Macdonald D, Perry J and Thiessen B: Canadian GBM Recommendations Committee: Canadian recommendations for the treatment of glioblastoma multiforme. Curr Oncol. 14:110–117. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Masuda TA, Inoue H, Sonoda H, Mine S, Yoshikawa Y, Nakayama K, Nakayama K and Mori M: Clinical and biological significance of S-phase kinase-associated protein 2 (Skp2) gene expression in gastric carcinoma: Modulation of malignant phenotype by Skp2 overexpression, possibly via p27 proteolysis. Cancer Res. 62:3819–3825. 2002.PubMed/NCBI

7 

Rosenblum MK: The 2007 WHO Classification of Nervous System Tumors: Newly recognized members of the mixed glioneuronal group. Brain Pathol. 17:308–313. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Weller M: Management of gliomas: Relevance of molecular markers for clinical practice. Eur Assoc Neuro Oncol Magazine. 2:6–10. 2012.

9 

Shaw E, Arusell R, Scheithauer B, et al: Prospective randomized trial of low-versus high-dose radiation therapy in adults with supratentorial low-grade glioma: Initial report of a North Central Cancer Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group study. J Clin Oncol. 20:2267–2276. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, et al: Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352:987–996. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Takanami I: The prognostic value of overexpression of Skp2 mRNA in non-small cell lung cancer. Oncol Rep. 13:727–731. 2005.PubMed/NCBI

12 

Kamata Y, Watanabe J, Nishimura Y, Arai T, Kawaguchi M, Hattori M, Obokata A and Kuramoto H: High expression of skp2 correlates with poor prognosis in endometrial endometrioid adenocarcinoma. J Cancer Res Clin Oncol. 131:591–596. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Pedeutour-Braccini Z, Burel-Vandenbos F, Gozé C, Roger C, Bazin A, Costes-Martineau V, Duffau H and Rigau V: Microfoci of malignant progression in diffuse low-grade gliomas: Towards the creation of an intermediate grade in glioma classification? Virchows Arch. 466:433–444. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Westhoff MA, Zhou S, Nonnenmacher L, Karpel-Massler G, Jennewein C, Schneider M, Halatsch ME, Carragher NO, Baumann B, Krause A, et al: Inhibition of NF-κ B signaling ablates the invasive phenotype of glioblastoma. Mol Cancer Res. 11:1611–1623. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Yang G, Ayala G, De Marzo A, Tian W, Frolov A, Wheeler TM, Thompson TC and Harper JW: Elevated Skp2 protein expression in human prostate cancer: Association with loss of the cyclin-dependent kinase inhibitor p27 and PTEN and with reduced recurrence-free survival. Clin Cancer Res. 8:3419–3426. 2002.PubMed/NCBI

16 

Ezoe S, Matsumura I, Nakata S, Gale K, Ishihara K, Minegishi N, Machii T, Kitamura T, Yamamoto M, Enver T, et al: GATA-2/estrogen receptor chimera regulates cytokine-dependent growth of hematopoietic cells through accumulation of p21 (WAF1) and p27 (Kip1) proteins. Blood. 100:3512–3520. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Kudo Y, Kitajima S, Sato S, Miyauchi M, Ogawa I and Takata T: High expression of S-phase kinase-interacting protein 2, human F-box protein, correlates with poor prognosis in oral squamous cell carcinomas. Cancer Res. 61:7044–7047. 2001.PubMed/NCBI

18 

Van Meir EG, Hadjipanayis CG, Norden AD, Shu HK, Wen PY and Olson J: Exciting new advances in neuro-oncology: The avenue to a cure for malignant glioma. CA Cancer J Clin. 60:166–193. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Mamillapalli R, Gavrilova N, Mihaylova VT, Tsvetkov LM, Wu H, Zhang H and Sun H: PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27 (KIP1) through the ubiquitin E3 ligase SCF (SKP2). Curr Biol. 11:263–267. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Dong Y, Sui L, Watanabe Y, Sugimoto K and Tokuda M: S-phase kinase-associated protein 2 expression in laryngeal squamous cell carcinomas and its prognostic implications. Oncol Rep. 10:321–325. 2003.PubMed/NCBI

21 

Koumarianou A, Tzeveleki I, Mekras D, Eleftheraki AG, Bobos M, Wirtz R, Fountzilas E, Valavanis C, Xanthakis I, Kalogeras KT, et al: Prognostic markers in early-stage colorectal cancer: Significance of TYMS mRNA expression. Anticancer Res. 34:4949–4962. 2014.PubMed/NCBI

22 

Gotanda K, Hirota T, Matsumoto N and Ieiri I: MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells. BMC Cancer. 13:3692013. View Article : Google Scholar : PubMed/NCBI

23 

von der Lehr N, Johansson S, Wu S, Bahram F, Castell A, Cetinkaya C, Hydbring P, Weidung I, Nakayama K, Nakayama KI, et al: The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell. 11:1189–1200. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Latres E, Chiarle R, Schulman BA, Pavletich NP, Pellicer A, Inghirami G and Pagano M: Role of the F-box protein Skp2 in lymphomagenesis. Proc Natl Acad Sci USA. 98:2515–2520. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Qin L, Wang CZ, Fan HJ, Zhang CJ, Zhang HW, Lv MH and Cui SD: A dual-targeting liposome conjugated with transferrin and arginine-glycine-aspartic acid peptide for glioma-targeting therapy. Oncol Lett. 8:2000–2006. 2014.PubMed/NCBI

26 

Hua W, Yao Y, Chu YW, Zhong P, Zhang R, Zhu W, Wu JS, Ma DX, Xu M, Mao Y and Zhou LF: Phase I study of dendritic cells pulsed with tumor stem-like cells associated antigens against malignant glioma in recurrent patients. Chin J Neurosurg. 27:90–93. 2011.

27 

Hart MG, Grant R, Garside R, Rogers G, Somerville M and Stein K: Temozolomide for high grade glioma. Cochrane Database Syst Rev. 8:CD0074152008.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ding B, Gao M, Li Z, Xu C, Fan S and He W: Expression of TYMS in lymph node metastasis from low‑grade glioma. Oncol Lett 10: 1569-1574, 2015.
APA
Ding, B., Gao, M., Li, Z., Xu, C., Fan, S., & He, W. (2015). Expression of TYMS in lymph node metastasis from low‑grade glioma. Oncology Letters, 10, 1569-1574. https://doi.org/10.3892/ol.2015.3419
MLA
Ding, B., Gao, M., Li, Z., Xu, C., Fan, S., He, W."Expression of TYMS in lymph node metastasis from low‑grade glioma". Oncology Letters 10.3 (2015): 1569-1574.
Chicago
Ding, B., Gao, M., Li, Z., Xu, C., Fan, S., He, W."Expression of TYMS in lymph node metastasis from low‑grade glioma". Oncology Letters 10, no. 3 (2015): 1569-1574. https://doi.org/10.3892/ol.2015.3419
Copy and paste a formatted citation
x
Spandidos Publications style
Ding B, Gao M, Li Z, Xu C, Fan S and He W: Expression of TYMS in lymph node metastasis from low‑grade glioma. Oncol Lett 10: 1569-1574, 2015.
APA
Ding, B., Gao, M., Li, Z., Xu, C., Fan, S., & He, W. (2015). Expression of TYMS in lymph node metastasis from low‑grade glioma. Oncology Letters, 10, 1569-1574. https://doi.org/10.3892/ol.2015.3419
MLA
Ding, B., Gao, M., Li, Z., Xu, C., Fan, S., He, W."Expression of TYMS in lymph node metastasis from low‑grade glioma". Oncology Letters 10.3 (2015): 1569-1574.
Chicago
Ding, B., Gao, M., Li, Z., Xu, C., Fan, S., He, W."Expression of TYMS in lymph node metastasis from low‑grade glioma". Oncology Letters 10, no. 3 (2015): 1569-1574. https://doi.org/10.3892/ol.2015.3419
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team