Cerebral tumefactive demyelinating lesions

  • Authors:
    • Wei Qi
    • Ge Jia
    • Xinsheng Wang
    • Maozhi Zhang
    • Zhenyu Ma
  • View Affiliations

  • Published online on: July 10, 2015     https://doi.org/10.3892/ol.2015.3481
  • Pages: 1763-1768
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Tumefactive demyelinating lesions (TDLs), are a rare demyelinating pathological disease in the central neurological system, which have been proven to be a diagnostic dilemma to neurosurgeons. The clinical presentation and radiographic appearance of these lesions often results in their misdiagnosis as intracranial tumors, such as gliomas, which leads to unnecessary surgical resection and adjunct radiation. In the present study, the clinical and radiographic features of 14 patients with cerebral TDLs who underwent surgical treatment between January 2004 and January 2009 were reviewed and analyzed. The surgical methods used included biopsy and resection, while steroid therapy was indicated when TDLs were confirmed by histopathological analysis. The patients were followed‑up and the outcomes were evaluated using the Karnofsky performance scale (KPS). The main clinical presentations included: Hemiplegia (8 cases), increased intracranial pressure (4 cases) and seizures (general in 1 case; partial in 3 cases). On magnetic resonance imaging scans, 12/14 TDL cases demonstrated an isolated local subcortical mass and 6/14 cases (42.9%) demonstrated enhancing veins coursing undistorted through the lesion. The postoperative complications included: Hemiplegia (2 cases) and mortality (1 case). A total of 9 cases underwent microsurgical total resection, and 5 cases received stereotactic biopsy that was followed with high‑dose methylprednisolone therapy. The follow‑up study demonstrated that 2 cases presented recurrence with multiple sclerosis and the KPS scores for 13/14 patients (92.9%) were ≥80. In conclusion, the clinical and radiographic features of TDLs may help to establish the correct diagnosis prior to surgery, in order to avoid unnecessary resection or adjunctive therapy. Using steroid therapy, the majority of patients with TDLs appeared to achieve satisfactory prognosis.
View Figures
View References

Related Articles

Journal Cover

Volume 10 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
Spandidos Publications style
Qi W, Jia G, Wang X, Zhang M and Ma Z: Cerebral tumefactive demyelinating lesions. Oncol Lett 10: 1763-1768, 2015
Qi, W., Jia, G., Wang, X., Zhang, M., & Ma, Z. (2015). Cerebral tumefactive demyelinating lesions. Oncology Letters, 10, 1763-1768. https://doi.org/10.3892/ol.2015.3481
Qi, W., Jia, G., Wang, X., Zhang, M., Ma, Z."Cerebral tumefactive demyelinating lesions". Oncology Letters 10.3 (2015): 1763-1768.
Qi, W., Jia, G., Wang, X., Zhang, M., Ma, Z."Cerebral tumefactive demyelinating lesions". Oncology Letters 10, no. 3 (2015): 1763-1768. https://doi.org/10.3892/ol.2015.3481