Chronic neutrophilic leukemia with overexpression of EVI-1, and concurrent CSF3R and SETBP1 mutations: A case report

Altangerel,Otgonbat; Cao,Shannan; Meng,Juanxia; Liu,Peng; Haiyan,Gong; Xu,Yuanfu; Zhao,Mingfeng

doi:10.3892/ol.2015.3485

September-2015 Volume 10 Issue 3

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September-2015 Volume 10 Issue 3

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Case Report

Chronic neutrophilic leukemia with overexpression of EVI-1, and concurrent CSF3R and SETBP1 mutations: A case report

Authors:
- Otgonbat Altangerel
- Shannan Cao
- Juanxia Meng
- Peng Liu
- Gong Haiyan
- Yuanfu Xu
- Mingfeng Zhao
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Affiliations: Department of Hematology, Tianjin First Central Hospital, First Central Clinical College of Tianjin Medical University, Tianjin 300192, P.R. China, State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, P.R. China
Pages: 1694-1700
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Published online on: July 13, 2015

https://doi.org/10.3892/ol.2015.3485
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Abstract

Chronic neutrophilic leukemia (CNL) is a rare type of myeloproliferative neoplasm, characterized by sustained neutrophilia, splenomegaly, bone marrow granulocytic hyperplasia (without evidence of dysplasia) and an absence of the Philadelphia chromosome. Thus far, ~150 cases of CNL have been described in the literature; however, none have demonstrated overexpression of the ecotropic viral integration site‑1 (EVI‑1, also known as MECOM) gene. The present study describes a case that fulfilled the World Health Organization diagnostic criteria for CNL, and was associated with overexpression of EVI‑1, as well as novel concurrent mutations of colony stimulating factor 3 receptor (CSF3R) and SET binding protein‑1 (SETBP1). In addition, the current study briefly reviewed the relevant literature regarding novel genetic findings associated with the diagnosis and treatment of CNL. To the best of our knowledge, this is the first case report of CNL with associated EVI‑1 overexpression, and concurrent CSF3R and SETBP1 mutations.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Chronic neutrophilic leukemia with overexpression of EVI-1, and concurrent CSF3R and SETBP1 mutations: A case report

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