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Genetic variability of DNA repair mechanisms influences treatment outcome of gastric cancer

  • Authors:
    • Changmao Ding
    • Huiyu Zhang
    • Kuisheng Chen
    • Chunlin Zhao
    • Jianbo Gao

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  • Published online on: July 17, 2015     https://doi.org/10.3892/ol.2015.3510
  • Pages: 1997-2002

  • Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the current study was to investigate the role of polymorphisms in DNA repair pathways on the clinical outcome of gastric cancer patients treated with platinum‑based chemotherapy. A total of 380 gastric cancer patients treated with platinum‑based chemotherapy were included in the present study. The genotypes of ERCC1 rs11615 (Asn118Asn) and rs3212986 (*197G>T), ERCC2 rs1799793 (Asn312Asp) and rs13181 (Lys751Gln), NBN rs1805794 (Gln185Gln) and rs1063054 (*1209A>C), RAD51 rs1801321 (‑61G>T) and rs12593359 (*502T>G), and XRCC3 rs861539 (Thr241Met) were determined by polymerase chain reaction‑restriction fragment length polymorphism, according to the manufacturer's instructions. The TC+CC genotypes of ERCC1 rs11615 and GA+AA genotypes of ERCC2 rs1799793 were found to be associated with improved response to chemotherapy, with an adjusted odds ratio of 1.66 (95% CI, 1.07‑2.56) and 1.61 (95% CI, 1.05‑2.49), respectively. Based on the results of Cox analysis, patients with TC+CC genotypes of ERCC1 rs11615 and GA+AA genotypes of ERCC2 rs1799793 exhibited a significantly decreased risk of mortality, with hazard ratios of 1.71 (95% CI, 1.06‑2.72) and 1.97 (95% CI, 1.28‑3.03), respectively. In conclusion, these results suggest that ERCC1 rs11615 and ERCC2 rs1799793 in the DNA repair pathways may be used as predictive factors of the clinical outcome in gastric cancer patients.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ding C, Zhang H, Chen K, Zhao C and Gao J: Genetic variability of DNA repair mechanisms influences treatment outcome of gastric cancer. Oncol Lett 10: 1997-2002, 2015
APA
Ding, C., Zhang, H., Chen, K., Zhao, C., & Gao, J. (2015). Genetic variability of DNA repair mechanisms influences treatment outcome of gastric cancer. Oncology Letters, 10, 1997-2002. https://doi.org/10.3892/ol.2015.3510
MLA
Ding, C., Zhang, H., Chen, K., Zhao, C., Gao, J."Genetic variability of DNA repair mechanisms influences treatment outcome of gastric cancer". Oncology Letters 10.4 (2015): 1997-2002.
Chicago
Ding, C., Zhang, H., Chen, K., Zhao, C., Gao, J."Genetic variability of DNA repair mechanisms influences treatment outcome of gastric cancer". Oncology Letters 10, no. 4 (2015): 1997-2002. https://doi.org/10.3892/ol.2015.3510