Carbogen gas-challenge blood oxygen level-dependent magnetic resonance imaging in hepatocellular carcinoma: Initial results

Zhang,Long  Jiang; Zhang,Zhuoli; Xu,Jian; Jin,Ning; Luo,Song; Larson,Andrew  C.; Lu,Guang  Ming

doi:10.3892/ol.2015.3526

October-2015 Volume 10 Issue 4

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October-2015 Volume 10 Issue 4

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Carbogen gas-challenge blood oxygen level-dependent magnetic resonance imaging in hepatocellular carcinoma: Initial results

Authors:
- Long Jiang Zhang
- Zhuoli Zhang
- Jian Xu
- Ning Jin
- Song Luo
- Andrew C. Larson
- Guang Ming Lu
View Affiliations / Copyright

Affiliations: Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nangjing, Jiangsu 210002, P.R. China, Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL 60611, USA

Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 2009-2014
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Published online on: July 23, 2015

https://doi.org/10.3892/ol.2015.3526
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Abstract

The present study aimed to evaluate the feasibility of performing carbogen gas-challenge blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) measurements in patients with hepatocellular carcinoma (HCC). A total of 25 patients with HCC underwent T2* mapping derived from multi‑echo gradient‑recalled echo imaging prior to and following breathing carbogen (95% O2 and 5% CO2) for 10 min. Follow‑up T2* mapping was performed in 5 patients 1 day after transarterial chemoembolization (TACE). T2*, R2* and ∆R2* values (R2*air ‑ R2*carb) of the whole tumor, the solid region of the tumor and the adjacent liver parenchyma were measured and compared in the patients with HCC. The T2* value of the solid region of the tumor following carbogen breathing was higher than the value following room air breathing (P<0.05), and the R2* value of room air breathing was higher than that following carbogen breathing (P<0.05). ∆R2* values of the tumor and the adjacent liver parenchyma prior to and following carbogen breathing were 2.4±7.8, 8.1±14.7 and 2.0±11.0 sec‑1, respectively. R2* values were significantly decreased in 2 cases 1 day after TACE (17.8 vs. ‑3.4 sec‑1 and 10.2 vs. 2.4 sec‑1). Overall, carbogen gas‑challenge BOLD MRI measurements are feasible in clinical settings and may serve as a novel functional biomarker for monitoring the treatment efficacy of embolic therapies for HCC.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Carbogen gas-challenge blood oxygen level-dependent magnetic resonance imaging in hepatocellular carcinoma: Initial results

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