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Article

FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion

  • Authors:
    • Jie Zhang
    • Wei Li
    • Song Dai
    • Xuhui Tai
    • Jianping Jia
    • Xing Guo
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Otolaryngology, The 463 Hospital of PLA, Shenyang, Liaoning 110007, P.R. China
  • Pages: 2499-2504
    |
    Published online on: July 23, 2015
       https://doi.org/10.3892/ol.2015.3530
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Abstract

Forkhead box Q1 (FOXQ1) is a forkhead transcription factor that is involved in numerous biological processes and has been shown to participate in tumorigenesis. However, the clinical significance of the expression of this protein in laryngeal carcinoma, and the mechanisms underlying its regulation in this disease remain unclear. The aim of present study was to measure the expression of FOXQ1 in laryngeal carcinoma, and to examine its effect on tumorigenesis. In the present study, reverse transcription‑quantitative polymerase chain reaction and western blotting were employed to measure FOXQ1 expression in laryngeal carcinoma tissue samples, small interfering RNA specific to FOXQ1, was transfected into Hep2 cells and its effect on cell proliferation, cell cycle progression and cell migration was examined, using a CCK‑8 assay, flow cytometry and a transwell migration assay, respectively. The results showed overexpression of FOXQ1 mRNA and protein in laryngeal cancer tissue samples. Inhibition of FOXQ1 suppressed cell growth and invasion, and arrested cells in the G0/G1 phase. Overexpression of FOXQ1 is associated with the development of laryngeal carcinoma and may enhance tumorigenesis through its effects on cell proliferation, cell cycle progression and cell migration.
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1 

Ragin CC, Modugno F and Gollin SM: The epidemiology and risk factors of head and neck cancer: A focus on human papillomavirus. J Dent Res. 86:104–114. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin. 57:43–66. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Knab BR, Salama JK, Solanki A, Stenson KM, Cohen EE, Witt ME, Haraf DJ and Vokes EE: Functional organ preservation with definitive chemoradiotherapy for T4 laryngeal squamous cell carcinoma. Ann Oncol. 19:1650–1654. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Du LB, Mao WM, Chen WQ, Zhang SW, Yu CD, Zheng RS, Xia QM and Wang XH: Incidence and mortality of larynx cancer in China during 2003–2007. Zhonghua Liu Xing Bing Xue Za Zhi. 33:395–398, (In Chinese). PubMed/NCBI

5 

Cripps C, Winquist E, Devries MC, StysNorman D and Gilbert R: Head and Neck Cancer Disease Site Group: Epidermal growth factor receptor targeted therapy in stages III and IV head and neck cancer. Curr Oncol. 17:37–48. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Ji W, Guan C and Pan Z: Analysis of curative effects on laryngeal carcinoma patients in the northeast region of China. Acta Otolaryngol. 128:574–577. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Ozdek A, Sarac S, Akyol MU, Sungur A and Yilmaz T: c-myc and bcl-2 Expression in supraglottic squamous cell carcinoma of the larynx. Otolaryngol Head Neck Surg. 131:77–83. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Jain P, Kumar P, Pai VR and Parikh PM: Neoadjuvant chemotherapy or chemoradiotherapy in head and neck cancer. Indian J Cancer. 45:83–89. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Bieller A, Pasche B, Frank S, Gläser B, Kunz J, Witt K and Zoll B: Isolation and characterization of the human forkhead gene FOXQ1. DNA Cell Biol. 20:555–561. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Feuerborn A, Srivastava PK, Küffer S, Grandy WA, Sijmonsma TP, Gretz N, Brors B and Gröne HJ: The Forkhead factor FoxQ1 influences epithelial differentiation. J Cell Physiol. 226:710–719. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Korver W, Roose J and Clevers H: The winged-helix transcription factor Trident is expressed in cycling cells. Nucleic Acids Res. 25:1715–1719. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Ogaki S, Harada S, Shiraki N, Kume K and Kume S: An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. BMC Dev Biol. 11:132011. View Article : Google Scholar : PubMed/NCBI

13 

Carlsson P and Mahlapuu M: Forkhead transcription factors: Key players in development and metabolism. Dev Biol. 250:1–23. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Candelario J, Chen LY, Marjoram P, Reddy S and Comai L: A filtering strategy identifies FOXQ1 as a potential effector of lamin A dysfunction. Aging (Albany NY). 4:567–577. 2012.PubMed/NCBI

15 

Sizemore ST and Keri RA: The forkhead box transcription factor FOXC1 promotes breast cancer invasion by inducing matrix metalloprotease 7 (MMP7) expression. J Biol Chem. 287:24631–24640. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Wendling DS, Lück C, von Schweinitz D and Kappler R: Characteristic overexpression of the forkhead box transcription factor Foxf1 in Patched-associated tumors. Int J Mol Med. 22:787–792. 2008.PubMed/NCBI

17 

Xia L, Huang W, Tian D, Zhu H, Qi X, Chen Z, Zhang Y, Hu H, Fan D, Nie Y, et al: Overexpression of forkhead box C1 promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma. Hepatology. 57:610–624. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Jonsson H and Peng SL: Forkhead transcription factors in immunology. Cell Mol Life Sci. 62:397–409. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Kaneda H, Arao T, Tanaka K, Tamura D, Aomatsu K, Kudo K, Sakai K, De Velasco MA, Matsumoto K, Fujita Y, et al: FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth. Cancer Res. 70:2053–2063. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Feng J, Zhang X, Zhu H, Wang X, Ni S and Huang J: FoxQ1 overexpression influences poor prognosis in non-small cell lung cancer, associates with the phenomenon of EMT. PLoS One. 7:e399372012. View Article : Google Scholar : PubMed/NCBI

21 

Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, Ethier SP, Miller F and Wu G: Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis. Cancer Res. 71:1292–1301. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Sobin LH and Wittekind C: Head and neck tumors, larynxTNM Classification of Malignant Tumors. 6th. Wiley-Liss; New York, NY: pp. 52–56. 2002

23 

Potter CS, Peterson RL, Barth JL, Pruett ND, Jacobs DF, Kern MJ, Argraves WS, Sundberg JP and Awgulewitsch A: Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation. J Biol Chem. 281:29245–29255. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Hong HK, Noveroske JK, Headon DJ, Liu T, Sy MS, Justice MJ and Chakravarti A: The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice. Genesis. 29:163–171. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Sun HT, Cheng SX, Tu Y, Li XH and Zhang S: FoxQ1 promotes glioma cells proliferation and migration by regulating NRXN3 expression. PLoS One. 8:e556932013. View Article : Google Scholar : PubMed/NCBI

26 

Qiao Y, Jiang X, Lee ST, Karuturi RK, Hooi SC and Yu Q: FOXQ1 regulates epithelial-mesenchymal transition in human cancers. Cancer Res. 71:3076–3086. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Gao M, Shih IeM and Wang TL: The role of forkhead box Q1 transcription factor in ovarian epithelial carcinomas. Int J Mol Sci. 13:13881–13893. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Qin J, Xu Y, Li X, Wu Y, Zhou J, Wang G and Chen L: Effects of lentiviral-mediated Foxp1 and Foxq1 RNAi on the hepatocarcinoma cell. Exp Mol Pathol. 96:1–8. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Piccolo S, Enzo E and Montagner M: p63, Sharp1, and HIFs: Master regulators of metastasis in triple-negative breast cancer. Cancer Res. 73:4978–4981. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Agarwal E, Brattain MG and Chowdhury S: Cell survival and metastasis regulation by Akt signaling in colorectal cancer. Cell Signal. 25:1711–1719. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Zhu Z, Pang Z, Xing Y, Wan F, Lan D and Wang H: Short hairpin RNA targeting FOXQ1 inhibits invasion and metastasis via the reversal of epithelial-mesenchymal transition in bladder cancer. Int J Oncol. 42:1271–1278. 2013.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang J, Li W, Dai S, Tai X, Jia J and Guo X: FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion. Oncol Lett 10: 2499-2504, 2015.
APA
Zhang, J., Li, W., Dai, S., Tai, X., Jia, J., & Guo, X. (2015). FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion. Oncology Letters, 10, 2499-2504. https://doi.org/10.3892/ol.2015.3530
MLA
Zhang, J., Li, W., Dai, S., Tai, X., Jia, J., Guo, X."FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion". Oncology Letters 10.4 (2015): 2499-2504.
Chicago
Zhang, J., Li, W., Dai, S., Tai, X., Jia, J., Guo, X."FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion". Oncology Letters 10, no. 4 (2015): 2499-2504. https://doi.org/10.3892/ol.2015.3530
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang J, Li W, Dai S, Tai X, Jia J and Guo X: FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion. Oncol Lett 10: 2499-2504, 2015.
APA
Zhang, J., Li, W., Dai, S., Tai, X., Jia, J., & Guo, X. (2015). FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion. Oncology Letters, 10, 2499-2504. https://doi.org/10.3892/ol.2015.3530
MLA
Zhang, J., Li, W., Dai, S., Tai, X., Jia, J., Guo, X."FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion". Oncology Letters 10.4 (2015): 2499-2504.
Chicago
Zhang, J., Li, W., Dai, S., Tai, X., Jia, J., Guo, X."FOXQ1 is overexpressed in laryngeal carcinoma and affects cell growth, cell cycle progression and cell invasion". Oncology Letters 10, no. 4 (2015): 2499-2504. https://doi.org/10.3892/ol.2015.3530
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