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ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma

  • Authors:
    • Jianheng Wu
    • Qiao Shan
    • Peidong Li
    • Yuehui Wu
    • Jingwei Xie
    • Xinjun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2075-2080
    |
    Published online on: July 30, 2015
       https://doi.org/10.3892/ol.2015.3548
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Abstract

Adenosine triphosphatase inhibitory factor 1 (IF1) has previously been considered to be a driving oncogene in human cancers. Several studies have revealed that IF1 overexpression is present in a variety of tumor types and promotes tumor growth and metastasis. The present study aimed to investigate the clinical significance of IF1 in glioma and the role of IF1 in cell migration and invasion. The mRNA and protein expression of IF1 in glioma tissues was found to be significantly increased compared with the expression in normal brain tissues (P<0.05). The presence of IF1 expression was significantly associated with an advanced clinical stage in glioma (P<0.05). Furthermore, the presence of IF1 expression was found to be associated with a reduced overall survival rate of glioma patients (P<0.05). Multivariate Cox regression analysis indicated that IF1 was an independent factor for predicting the overall survival rate of patients with glioma (P<0.05). IF1 knockdown also significantly reduced the number of migratory and invasive U251 and U87 cells (P<0.05). In addition, IF1 knockdown inhibited the expression of nuclear factor‑κB (NF‑κB) and Snai1, and led to increased E‑cadherin expression and reduced vimentin expression. In conclusion, the presence of IF1 expression is associated with poor clinicopathological features in glioma. IF1 expression is an independent prognostic marker for predicting the overall survival rate of patients with glioma. Mechanistically, IF1 may promote glioma cell migration and invasion through the NF‑κB/Snai1 axis.
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Copy and paste a formatted citation
Spandidos Publications style
Wu J, Shan Q, Li P, Wu Y, Xie J and Wang X: ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma. Oncol Lett 10: 2075-2080, 2015.
APA
Wu, J., Shan, Q., Li, P., Wu, Y., Xie, J., & Wang, X. (2015). ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma. Oncology Letters, 10, 2075-2080. https://doi.org/10.3892/ol.2015.3548
MLA
Wu, J., Shan, Q., Li, P., Wu, Y., Xie, J., Wang, X."ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma". Oncology Letters 10.4 (2015): 2075-2080.
Chicago
Wu, J., Shan, Q., Li, P., Wu, Y., Xie, J., Wang, X."ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma". Oncology Letters 10, no. 4 (2015): 2075-2080. https://doi.org/10.3892/ol.2015.3548
Copy and paste a formatted citation
x
Spandidos Publications style
Wu J, Shan Q, Li P, Wu Y, Xie J and Wang X: ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma. Oncol Lett 10: 2075-2080, 2015.
APA
Wu, J., Shan, Q., Li, P., Wu, Y., Xie, J., & Wang, X. (2015). ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma. Oncology Letters, 10, 2075-2080. https://doi.org/10.3892/ol.2015.3548
MLA
Wu, J., Shan, Q., Li, P., Wu, Y., Xie, J., Wang, X."ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma". Oncology Letters 10.4 (2015): 2075-2080.
Chicago
Wu, J., Shan, Q., Li, P., Wu, Y., Xie, J., Wang, X."ATPase inhibitory factor 1 is a potential prognostic marker for the migration and invasion of glioma". Oncology Letters 10, no. 4 (2015): 2075-2080. https://doi.org/10.3892/ol.2015.3548
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