Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature

  • Authors:
    • Ping Ai
    • Xingchen Peng
    • Yong Jiang
    • Hong Zhang
    • Shichao Wang
    • Yuquan Wei
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  • Published online on: August 4, 2015     https://doi.org/10.3892/ol.2015.3574
  • Pages: 2329-2332
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Abstract

Adult pineoblastomas (PBs) are rare central nervous system tumors. Little is known with regard to the clinical features and outcomes of adult PB, and optimal treatment strategies for adult PB remain to be determined. The current report describes a case of PB in a 46‑year‑old male, who presented with obstructive hydrocephalus due to a large pineal region mass. Considering the potential effect on quality of life, the patient underwent a partial resection. Postoperative radiotherapy, comprising prophylactic craniospinal irradiation at a dose of 34.2 Gy followed by a local 25.3‑Gy ‘boost’ to the tumor site for a total dose of 59.5 Gy, resulted in the complete regression of the tumor without neurological deficits. The patient has remained free of recurrence for 36 months after radiotherapy. This case highlights a minimally invasive strategy to treat a rare pineal region tumor with significant involvement of critical structures that resulted in a favorable response and an excellent neurological outcome. The radiographic and histopathological features of PB are also reviewed, and the various treatment options reported in the literature are discussed.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Ai P, Peng X, Jiang Y, Zhang H, Wang S and Wei Y: Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature. Oncol Lett 10: 2329-2332, 2015
APA
Ai, P., Peng, X., Jiang, Y., Zhang, H., Wang, S., & Wei, Y. (2015). Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature. Oncology Letters, 10, 2329-2332. https://doi.org/10.3892/ol.2015.3574
MLA
Ai, P., Peng, X., Jiang, Y., Zhang, H., Wang, S., Wei, Y."Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature". Oncology Letters 10.4 (2015): 2329-2332.
Chicago
Ai, P., Peng, X., Jiang, Y., Zhang, H., Wang, S., Wei, Y."Complete regression of adult pineoblastoma following radiotherapy: A case report and review of the literature". Oncology Letters 10, no. 4 (2015): 2329-2332. https://doi.org/10.3892/ol.2015.3574