Inverted (hobnail) high‑grade prostatic intraepithelial neoplasia and invasive inverted pattern

Öznur,Meltem; Koca,Sevim Baykal; Yıldız,Pelin; Bahadır,Burak; Behzatoğlu,Kemal

doi:10.3892/ol.2015.3584

October-2015 Volume 10 Issue 4

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October-2015 Volume 10 Issue 4

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Article

Inverted (hobnail) high‑grade prostatic intraepithelial neoplasia and invasive inverted pattern

Authors:
- Meltem Öznur
- Sevim Baykal Koca
- Pelin Yıldız
- Burak Bahadır
- Kemal Behzatoğlu
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Affiliations: Department of Pathology, Medical Faculty, Namık Kemal University, Tekirdağ 59100, Turkey, Department of Pathology, Patnos Hospital, Ağrı 04001, Turkey, Department of Pathology, Medical Faculty, Bezmialem University, Istanbul 34093, Turkey, Department of Pathology, Medical Faculty, Bülent Ecevit University, Zonguldak 67100, Turkey, Department of Pathology, Istanbul Education and Research Hospital, Istanbul 34098, Turkey
Pages: 2395-2399
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Published online on: August 10, 2015

https://doi.org/10.3892/ol.2015.3584
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Abstract

High‑grade prostatic intraepithelial neoplasia (HGPIN) is considered to be an important precursor for prostatic adenocarcinoma. The present study aimed to investigate the histological features of the uncommon inverted (hobnail) pattern of HGPIN in transrectal ultrasonographic (TRUS) prostatic needle biopsies from 13 cases. These 13 diagnosed cases of inverted HGPIN were identified out of a total of 2,034 TRUS biopsies (0.63%), obtained from patients suspected to have prostate cancer. The hobnail pattern is comprised of secretory cell nuclei, which are histologically localized at the luminal surface of the prostate gland, rather than the periphery, and exhibit reverse polarity. Histological examinations were performed and the results demonstrated that 5 of the 13 cases exhibited pure inverted histology, while HGPIN was observed to be histologically associated with other patterns in the remaining 8 patients. In addition, an association with adenocarcinoma was identified in 7 of the 13 cases. All 7 carcinomas accompanied by inverted HGPIN were conventional acinar adenocarcinoma cases; of note, for these 7 cases, the Gleason score was 7 for each. One acinar adenocarcinoma case accompanying inverted HGPIN demonstrated hobnail characteristics in large areas of the invasive component. It was observed that nuclei were proliferated in the invasive cribriform glands, which was comparable to that of inverted HGPIN, and were located on the cytoplasmic luminal surface; a similar morphology was also observed in individual glands. In conclusion, the results of the present study suggested that the hobnail HGPIN pattern may be of diagnostic importance due to its high association with adenocarcinoma and the high Gleason scores in the accompanying carcinomas.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Inverted (hobnail) high‑grade prostatic intraepithelial neoplasia and invasive inverted pattern

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