Metastasis of myxoid liposarcoma to fat‑bearing areas: A case report of unusual metastatic sites and a hypothesis

  • Authors:
    • Shuchen Lin
    • Zhihua Gan
    • Kun Han
    • Yang Yao
    • Daliu Min
  • View Affiliations

  • Published online on: August 10, 2015     https://doi.org/10.3892/ol.2015.3585
  • Pages: 2543-2546
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Abstract

Sarcoma is a rare disease that always metastasizes to the lungs and bones. Myxoid liposarcoma (MLPS), in comparison with other sarcomas, has a distinct biological characteristic. Recent studies have suggested that MLPS expresses high levels of adipophilin and chemokine (C‑X‑C motif) receptor 4 (CXCR4), which are correlated with adipogenesis and metastasis. In addition, the Ewing sarcoma breakpoint region 1‑DNA damage‑inducible transcript 3 (EWSR1‑DDIT3) fusion transcript, recently identified in MLPS, was shown to selectively repress the osteoblastic transcription in multipotent mesenchymal cells. The present study reported a rare case of MLPS with metastasis in fat‑bearing areas, including the bones, epidural region, orbits and abdominal cavity, while the lungs were not involved. Bone metastasis was diagnosed by magnetic resonance imaging and proven by histology. However, bone scanning lacked sufficient sensitivity to detect the bone metastasis. Based on these findings, we hypothesized that molecular adipophilin and molecular CXCR4 may contribute to the fat‑bearing area metastasis pattern. Furthermore, the EWSR1‑DDIT3 fusion transcript may repress the osteoblastic activity in the bone metastases, ultimately resulting in a low detection rate by bone scans.
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October-2015
Volume 10 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Lin S, Gan Z, Han K, Yao Y and Min D: Metastasis of myxoid liposarcoma to fat‑bearing areas: A case report of unusual metastatic sites and a hypothesis. Oncol Lett 10: 2543-2546, 2015
APA
Lin, S., Gan, Z., Han, K., Yao, Y., & Min, D. (2015). Metastasis of myxoid liposarcoma to fat‑bearing areas: A case report of unusual metastatic sites and a hypothesis. Oncology Letters, 10, 2543-2546. https://doi.org/10.3892/ol.2015.3585
MLA
Lin, S., Gan, Z., Han, K., Yao, Y., Min, D."Metastasis of myxoid liposarcoma to fat‑bearing areas: A case report of unusual metastatic sites and a hypothesis". Oncology Letters 10.4 (2015): 2543-2546.
Chicago
Lin, S., Gan, Z., Han, K., Yao, Y., Min, D."Metastasis of myxoid liposarcoma to fat‑bearing areas: A case report of unusual metastatic sites and a hypothesis". Oncology Letters 10, no. 4 (2015): 2543-2546. https://doi.org/10.3892/ol.2015.3585