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Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET‑amplified patient‑derived gastric cancer xenografts

  • Authors:
    • Kai Liu
    • Xilin Song
    • Meirong Zhu
    • Heng Ma
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Shandong Tumor Hospital, Jinan, Shandong 250117, P.R. China, Intensive Care Unit, Jinan Central Hospital, Jinan, Shandong 250013, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2003-2008
    |
    Published online on: August 12, 2015
       https://doi.org/10.3892/ol.2015.3601
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Abstract

Gastric cancer is one of the most malignant diseases and one of the leading causes of cancer‑associated mortality worldwide. Although advances have been made in surgical techniques, perioperative management and the combined use of surgery with chemotherapy and/or radiotherapy, patients with advanced stage gastric cancer continue to face poor outcomes. Furthermore, it was reported that MET gene amplification and overexpression predicted the sensitivity to MET inhibitors in gastric cancer. However, the identification of drug‑resistant tumors has encouraged the pre‑emptive elucidation of the possible mechanisms of clinical resistance. The current study assessed a number of patient‑derived gastric cancer models with MET amplification and overexpression, including CNGAS028. The tumor tissues were subjected to microarray analysis (using single nucleotide polymorphism 6.0 and human genome U133 arrays) followed by western blotting. The results demonstrated that CNGAS028 xenograft tumors did not respond to treatment with a selective MET inhibitor. Additional analysis indicated that FGFR2 overexpression contributed to the resistance to MET inhibitors. Furthermore, treatment with a combination of fibroblast growth factor receptor 2 and MET inhibitors inhibited the growth of CNGAS028 xenograft tumors in vivo. In conclusion, the current results aid in understanding the mechanism of inherent resistance to selective MET inhibitors as well as provide important information for patient selection and clinical treatment strategies.
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Copy and paste a formatted citation
Spandidos Publications style
Liu K, Song X, Zhu M and Ma H: Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET‑amplified patient‑derived gastric cancer xenografts. Oncol Lett 10: 2003-2008, 2015.
APA
Liu, K., Song, X., Zhu, M., & Ma, H. (2015). Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET‑amplified patient‑derived gastric cancer xenografts. Oncology Letters, 10, 2003-2008. https://doi.org/10.3892/ol.2015.3601
MLA
Liu, K., Song, X., Zhu, M., Ma, H."Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET‑amplified patient‑derived gastric cancer xenografts". Oncology Letters 10.4 (2015): 2003-2008.
Chicago
Liu, K., Song, X., Zhu, M., Ma, H."Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET‑amplified patient‑derived gastric cancer xenografts". Oncology Letters 10, no. 4 (2015): 2003-2008. https://doi.org/10.3892/ol.2015.3601
Copy and paste a formatted citation
x
Spandidos Publications style
Liu K, Song X, Zhu M and Ma H: Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET‑amplified patient‑derived gastric cancer xenografts. Oncol Lett 10: 2003-2008, 2015.
APA
Liu, K., Song, X., Zhu, M., & Ma, H. (2015). Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET‑amplified patient‑derived gastric cancer xenografts. Oncology Letters, 10, 2003-2008. https://doi.org/10.3892/ol.2015.3601
MLA
Liu, K., Song, X., Zhu, M., Ma, H."Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET‑amplified patient‑derived gastric cancer xenografts". Oncology Letters 10.4 (2015): 2003-2008.
Chicago
Liu, K., Song, X., Zhu, M., Ma, H."Overexpression of FGFR2 contributes to inherent resistance to MET inhibitors in MET‑amplified patient‑derived gastric cancer xenografts". Oncology Letters 10, no. 4 (2015): 2003-2008. https://doi.org/10.3892/ol.2015.3601
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