Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2015 Volume 10 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Loss of heterozygosis on chromosome 18q21-23 and muscle-invasive bladder cancer natural history

  • Authors:
    • Tommaso Cai
    • Nicola Mondaini
    • Daniele Tiscione
    • Maurizio Dal Canto
    • Raffaella Santi
    • Riccardo Bartoletti
    • Gabriella Nesi
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Santa Chiara Regional Hospital, Trento 38123, Italy, Department of Urology, University of Florence, Florence 50121, Italy, Department of Medical Genetics, University of Florence, Florence 50121, Italy, Department of Pathology and Oncology, University of Florence, Florence 50121, Italy
  • Pages: 2569-2573
    |
    Published online on: August 17, 2015
       https://doi.org/10.3892/ol.2015.3616
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Loss of heterozygosis (LOH) on chromosome (Chr) 18q21-23 was reported to be one of the most common genetic alterations identified in bladder cancer. The current study aimed to determine the prognostic role of LOH on Chr 18q21-23 in patients diagnosed with muscle‑invasive urothelial bladder carcinoma (MIBC). A total of 34 consecutive patients were enrolled in the present prospective study. LOH on Chr 18 was assessed by performing multiplex polymerase chain reaction on paired blood and tumour tissue samples from each patient. The following primers were used in the present study: D18S51, MBP LW and MBP H. These data were then compared with follow‑up information. The main outcome measure was patient status at the end of the follow‑up. Cox regression was used to evaluate the impact of each parameter on cancer‑specific survival and the Kaplan Meier test for disease‑free survival was plotted in order to estimate survival. Out of 34 patients, 18 (52.9%) exhibited ≥1 alteration in one of the loci analysed on chromosome 18, while 16 (47.1%) revealed no alterations. No correlation was identified with stage (P=0.18) or grade (P=0.06); however, LOH on Chr 18q21‑23 was significantly associated with a lower recurrence‑free probability (P<0.0001). Kaplan‑Meier curves demonstrated a significant association between patient status at follow‑up and LOH on Chr 18 (P<0.001). In addition, multivariate analysis identified LOH on Chr 18 (P<0.001) and stage (P=0.01) as independent survival predictors. Furthermore, artificial neural network analysis was consistent with the results of the multivariate analysis. In conclusion, the present study highlighted the role of LOH on Chr 18q21-23 in predicting the clinical outcome of patients with MIBC.
View Figures

Figure 1

View References

1 

Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2007. CA Cancer J Clin. 57:43–66. 2007. View Article : Google Scholar : PubMed/NCBI

2 

MhawechFauceglia P, Cheney RT and Schwaller J: Genetic alterations in urothelial bladder carcinoma: An updated review. Cancer. 106:1205–1216. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Tomasini JM and Konety BR: Urinary markers/cytology: What and when should a urologist use. Urol Clin North Am. 40:165–173. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Cai T, Nesi G, Dal Canto M, Mondaini N, Piazzini M and Bartoletti R: Prognostic role of loss of heterozygosity on chromosome 18 in patients with low-risk nonmuscle-invasive bladder cancer: Results from a prospective study. J Surg Res. 161:89–94. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Bartoletti R, Cai T, Nesi G, Roberta Girardi L, Baroni G and Dal Canto M: Loss of P16 expression and chromosome 9p21 LOH in predicting outcome of patients affected by superficial bladder cancer. J Surg Res. 143:422–427. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Bartoletti R, Cai T, Dal Canto M, Boddi V, Nesi G and Piazzini M: Multiplex polymerase chain reaction for microsatellite analysis of urine sediment cells: A rapid and inexpensive method for diagnosing and monitoring superficial transitional bladder cell carcinoma. J Urol. 175:2032–2037. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Knowles MA: What we could do now: Molecular pathology of bladder cancer. Mol Pathol. 54:215–221. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Uchida A, Tachibana M, Miyakawa A, Nakamura K and Murai M: Microsatellite analysis in multiple chromosomal regions as a prognostic indicator of primary bladder cancer. Urol Res. 28:297–303. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Switula D: Principles of good clinical practice (GCP) in clinical research. Sci Eng Ethics. 6:71–77. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Polymeropoulos MH, Xiao H and Merril CR: Tetranucleotide repeat polymorphism at the human myelin basic protein gene (MBP). Hum Mol Genet. 1:6581992. View Article : Google Scholar : PubMed/NCBI

11 

Bartoletti R, Dal Canto M, Cai T, Piazzini M, Travaglini F, Gavazzi A and Rizzo M: Early diagnosis and monitoring of superficial transitional cell carcinoma by microsatellite analysis on urine sediment. Oncol Rep. 13:531–537. 2005.PubMed/NCBI

12 

DalCanto M, Bartoletti R, Travaglini F, Piazzini M, Lodovichi G, Rizzo M and Selli C: Molecular urinary sediment analysis in patients with transitional cell bladder carcinoma. Anticancer Res. 23:5095–5100. 2003.PubMed/NCBI

13 

Edge SB, Byrd DR, Compton CC, et al: American Joint Committee on Cancer Staging Manual. 7th. Springer; New York, NY: pp. 117–126. 2010

14 

Eble JN, Sauter G, Epstein JI and Sesterhenn IA: World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of the Urinary System and Male Genital Organs. IARC Press; Lyon, France: pp. 89–154. 2004

15 

Gakis G, Efstathiou J, Lerner SP, et al: International Consultation on Urologic Disease-European Association of Urology Consultation on Bladder Cancer 2012: ICUD-EAU International Consultation on Bladder Cancer 2012: Radical cystectomy and bladder preservation for muscle-invasive urothelial carcinoma of the bladder. Eur Urol. 63:45–57. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Stenzl A, Cowan NC, De Santis M, Kuczyk MA, Merseburger AS, Ribal MJ, Sherif A and Witjes JA: European Association of Urology (EAU): Treatment of muscle-invasive and metastatic bladder cancer: Update of the EAU guidelines. Eur Urol. 59:1009–1018. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Cai T, Conti G, Lorenzini M and Bartoletti R: Artificial intelligences in urological practice: The key to success? Ann Oncol. 18:6042007. View Article : Google Scholar : PubMed/NCBI

18 

Cai T, Conti G, Nesi G, et al: Artificial intelligence for predicting recurrence-free probability of noninvasive high-grade urothelial bladder cell carcinoma. Oncol Rep. 18:959–964. 2007.PubMed/NCBI

19 

Lee SE and Park MS: Prognostic factors for survival in patients with transitional cell carcinoma of the bladder: Evaluation by histopathologic grade, pathologic stage and flow-cytometric analysis. Eur Urol. 29:193–198. 1996.PubMed/NCBI

20 

GarciaClosas M, Ye Y, Rothman N, Figueroa JD, Malats N, Dinney CP, Chatterjee N, Prokunina Olsson L, Wang Z, Lin J, et al: A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3. Hum Mol Genet. 20:4282–4289. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Koutros S, Baris D, Fischer A, et al: Differential urinary specific gravity as a molecular phenotype of the bladder cancer genetic association in the urea transporter gene, SLC14A1. Int J Cancer. 133:3008–3013. 2013.PubMed/NCBI

22 

Brewster SF, Gingell JC, Browne S and Brown KW: Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder. Br J Cancer. 70:697–700. 1994. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cai T, Mondaini N, Tiscione D, Dal Canto M, Santi R, Bartoletti R and Nesi G: Loss of heterozygosis on chromosome 18q21-23 and muscle-invasive bladder cancer natural history. Oncol Lett 10: 2569-2573, 2015.
APA
Cai, T., Mondaini, N., Tiscione, D., Dal Canto, M., Santi, R., Bartoletti, R., & Nesi, G. (2015). Loss of heterozygosis on chromosome 18q21-23 and muscle-invasive bladder cancer natural history. Oncology Letters, 10, 2569-2573. https://doi.org/10.3892/ol.2015.3616
MLA
Cai, T., Mondaini, N., Tiscione, D., Dal Canto, M., Santi, R., Bartoletti, R., Nesi, G."Loss of heterozygosis on chromosome 18q21-23 and muscle-invasive bladder cancer natural history". Oncology Letters 10.4 (2015): 2569-2573.
Chicago
Cai, T., Mondaini, N., Tiscione, D., Dal Canto, M., Santi, R., Bartoletti, R., Nesi, G."Loss of heterozygosis on chromosome 18q21-23 and muscle-invasive bladder cancer natural history". Oncology Letters 10, no. 4 (2015): 2569-2573. https://doi.org/10.3892/ol.2015.3616
Copy and paste a formatted citation
x
Spandidos Publications style
Cai T, Mondaini N, Tiscione D, Dal Canto M, Santi R, Bartoletti R and Nesi G: Loss of heterozygosis on chromosome 18q21-23 and muscle-invasive bladder cancer natural history. Oncol Lett 10: 2569-2573, 2015.
APA
Cai, T., Mondaini, N., Tiscione, D., Dal Canto, M., Santi, R., Bartoletti, R., & Nesi, G. (2015). Loss of heterozygosis on chromosome 18q21-23 and muscle-invasive bladder cancer natural history. Oncology Letters, 10, 2569-2573. https://doi.org/10.3892/ol.2015.3616
MLA
Cai, T., Mondaini, N., Tiscione, D., Dal Canto, M., Santi, R., Bartoletti, R., Nesi, G."Loss of heterozygosis on chromosome 18q21-23 and muscle-invasive bladder cancer natural history". Oncology Letters 10.4 (2015): 2569-2573.
Chicago
Cai, T., Mondaini, N., Tiscione, D., Dal Canto, M., Santi, R., Bartoletti, R., Nesi, G."Loss of heterozygosis on chromosome 18q21-23 and muscle-invasive bladder cancer natural history". Oncology Letters 10, no. 4 (2015): 2569-2573. https://doi.org/10.3892/ol.2015.3616
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team